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Table 2 Association of indices of insulin resistance and β-cell function to glucose tolerance status

From: Differential role of insulin resistance and β-cell function in the development of prediabetes and diabetes in middle-aged and elderly Chinese population

Variables Prediabetes vs. NGT T2DM vs. prediabetes
Crude OR (95% CI) Adjusted OR (95% CI) Crude OR (95% CI) Adjusted OR (95% CI)
Adipo-IR
 Q1 (≤ 1.52) Ref. Ref. Ref. Ref.
 Q2 (1.53–2.37) 2.35 (1.29–4.29) 2.78 (1.44–5.38) 0.68 (0.26–1.76) 0.71 (0.21–2.38)
 Q3 (2.38–3.70) 2.47 (1.36–4.49) 2.74 (1.37–5.46) 1.00 (0.41–2.44) 0.84 (0.26–2.78)
 Q4 (≥ 3.71) 6.40 (3.43–11.92) 7.03 (3.23–15.32) 1.53 (0.67–3.49) 1.74 (0.51–5.96)
HOMA-IR
 Q1 (≤ 0.87) Ref. Ref. Ref. Ref.
 Q2 (0.88–1.29) 1.46 (0.82–2.61) 1.31 (0.68–2.50) 0.54 (0.19–1.51) 0.32 (0.09–1.09)
 Q3 (1.30–1.91) 2.00 (1.13–3.54) 1.77 (0.87–3.60) 1.30 (0.55–3.07) 0.85 (0.28–2.61)
 Q4 (≥ 1.92) 3.76 (2.06–6.84) 3.01 (1.40–6.48) 2.19 (0.98–4.91) 0.74 (0.22–2.46)
HOMA-β
 Q1 (≤ 40.12) Ref. Ref. Ref. Ref.
 Q2 (40.13–56.04) 0.71 (0.40–1.27) 0.62 (0.33–1.19) 0.43 (0.21–0.90) 0.45 (0.17–1.22)
 Q3 (56.05–80.23) 1.07 (0.61–1.87) 0.90 (0.46–1.76) 0.19 (0.08–0.42) 0.11 (0.04–0.34)
 Q4 (≥ 80.24) 1.31 (0.74–2.30) 0.87 (0.41–1.86) 0.27 (0.13–0.56) 0.22 (0.08–0.66)
Fasting CPRI
 Q1 (≤ 1.16) Ref. Ref. Ref. Ref.
 Q2 (1.17–1.48) 0.97 (0.54–1.76) 0.73 (0.39–1.38) 0.84 (0.40–1.74) 1.00 (0.38–2.64)
 Q3 (1.49–1.92) 1.81 (1.02–3.19) 1.25 (0.65–2.41) 0.31 (0.14–0.69) 0.24 (0.07–0.75)
 Q4 (≥ 1.93) 2.20 (1.24–3.91) 1.27 (0.61–2.66) 0.38 (0.18–0.80) 0.26 (0.08–0.83)
Postprandial CPRI
 Q1 (≤ 4.41) Ref. Ref. Ref. Ref.
 Q2 (4.42–5.53) 1.35 (0.76–2.41) 1.14 (0.60–2.13) 0.18 (0.08–0.41) 0.16 (0.06–0.46)
 Q3 (5.54–7.08) 1.11 (0.62–1.99) 0.78 (0.41–1.48) 0.14 (0.05–0.35) 0.22 (0.08–0.63)
 Q4 (≥ 7.09) 0.85 (0.47–1.53) 0.55 (0.28–1.07) 0.07 (0.02–0.24) 0.08 (0.02–0.31)
  1. P and OR: from multivariate logistic regression analysis. The adjusted model included sex, age, BMI, drinking status, LDL-C and HbA1c
  2. Statistically significance values are in italics (p < 0.05)