|
Predictor variables
|
Men and women
|
Men
|
Women
|
|---|
|
Hazard ratio (95% CI)
|
p-value
|
Hazard ratio (95% CI)
|
p-value
|
Hazard ratio (95% CI)
|
p-value
|
|---|
|
Main effects
|
|
Total bilirubin (low total bilirubin)
|
|
High total bilirubin
|
0.70 (0.59–0.85)
|
0.0001
|
0.82 (0.66–1.01)
|
0.0677
|
0.60 (0.43–0.84)
|
0.0022
|
|
Gamma-glutamyltransferase (low gamma-glutamyltransferase)
|
|
High gamma-glutamyltransferase
|
3.21 (2.69–3.87)
|
< 0.0001
|
2.99 (2.42–3.73)
|
< 0.0001
|
3.67 (2.66–5.20)
|
< 0.0001
|
|
Interaction effects
|
|
Total bilirubin × gamma-glutamyltransferase
| |
0.0222
| |
0.0764
| |
0.0857
|
- The overall total bilirubin range was divided into two subranges: low total bilirubin (< 15.4 μmol/L in men and < 12.0 μmol/L in women) and high total bilirubin (≥ 15.4 μmol/L in men and ≥ 12.0 μmol/L in women). The overall gamma-glutamyltransferase range was also divided into two subranges: low gamma-glutamyltransferase (< 0.44 μkat/L in men and < 0.26 μkat/L in women) and high gamma-glutamyltransferase (≥ 0.44 μkat/L in men and ≥ 0.26 μkat/L in women). The level of significance for the interaction term was p < 0.1
- CI confidence interval
