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Table 2 Cox regression analysis of significant main effects and interactions of total bilirubin and gamma-glutamyltransferase on incident metabolic syndrome

From: Potential impact of the joint association of total bilirubin and gamma-glutamyltransferase with metabolic syndrome

Predictor variables Men and women Men Women
Hazard ratio (95% CI) p-value Hazard ratio (95% CI) p-value Hazard ratio (95% CI) p-value
Main effects
 Total bilirubin (low total bilirubin)
  High total bilirubin 0.70 (0.59–0.85) 0.0001 0.82 (0.66–1.01) 0.0677 0.60 (0.43–0.84) 0.0022
 Gamma-glutamyltransferase (low gamma-glutamyltransferase)
  High gamma-glutamyltransferase 3.21 (2.69–3.87) < 0.0001 2.99 (2.42–3.73) < 0.0001 3.67 (2.66–5.20) < 0.0001
Interaction effects
 Total bilirubin × gamma-glutamyltransferase   0.0222   0.0764   0.0857
  1. The overall total bilirubin range was divided into two subranges: low total bilirubin (< 15.4 μmol/L in men and < 12.0 μmol/L in women) and high total bilirubin (≥ 15.4 μmol/L in men and ≥ 12.0 μmol/L in women). The overall gamma-glutamyltransferase range was also divided into two subranges: low gamma-glutamyltransferase (< 0.44 μkat/L in men and < 0.26 μkat/L in women) and high gamma-glutamyltransferase (≥ 0.44 μkat/L in men and ≥ 0.26 μkat/L in women). The level of significance for the interaction term was p < 0.1
  2. CI confidence interval