Table 2 Results of weight and laboratory parameters of C-Reactive Protein, tumor necrosis factor alpha, and glycosylated hemoglobin measured before and 8 weeks after treatment with exenatide in a subcohort of 56 patients with type 2 diabetes mellitus, subdivided according to TCF7L2 genotype
From: Effect of TCF7L2 polymorphism on pancreatic hormones after exenatide in type 2 diabetes
Variable | Comparison | Standard error | p | IC (95%) | |
|---|---|---|---|---|---|
Inferior | Superior | ||||
Weight (kg) | CC (pre) VS CC (post) | 0.04 | < 0.001 | 2.08 | 2.25 |
CC (pre) VS CT/TT (pre) | 3.71 | NS | − 7.51 | 7.05 | |
CC (post) VS CT/TT (post) | 3.71 | NS | − 7.19 | 7.37 | |
CT/TT (pre) VS CT/TT (post) | 0.04 | < 0.001 | 2.41 | 2.56 | |
HbA1C (%) | Pre × post | 0.11 | 0.036 | 0.02 | 0.46 |
CRP (mg/dL) | CC (pre) × CC (post) | 0.33 | NS | − 1.02 | 0.27 |
CC (pre) × CT/TT (pre) | 1.27 | NS | − 4.18 | 0.81 | |
CC (post) × CT/TT (post) | 1.15 | NS | − 2.52 | 1.99 | |
CT/TT(pre) × CT/TT(post) | 0.46 | NS | 0.15 | 1.94 | |
TNFα (pg/mL) | CC × CT/TT | 0.12 | < 0.001 | − 0.96 | − 0.48 |
Pre × post | 0.04 | < 0.001 | 0.23 | 0.41 | |