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Table 5 Analysis of the relationship between the MTHFR methylation pattern and the C677C polymorphism of MTHFR and biochemical, inflammatory and oxidative stress variables associated with clinical condition

From: The MTHFR promoter hypermethylation pattern associated with the A1298C polymorphism influences lipid parameters and glycemic control in diabetic patients

 

With complications (20)

Control (22)

With complications (27)

Control (38)

Methylated CC (11)

MethylatedTC (6) + TT (3)

p

Methylated CC (10)

Methylated TC (12)

p

Partially Methylated CC (10)

Partially MethylatedTC (16) + TT (1)

p

Partially Methylated CC (20)

Partially MethylatedTC (17) + TT (1)

p

HbA1c

Mean  ±  SD

Median

9.7 ± 2.9

9.0

7.8 ± 1.1

7.7

0.3231

7.2 ± 1.3

7.2

8.1 ± 1.3

8.0

0.1984

8.4 ± 1.4

8.2

8.6 ± 1.8

8.0

0.9399

8.2 ± 1.9

8.3

8.0 ± 2.1

7.6

0.5785

Min.–Max.

6.4–14.4

5.7–9.6

5.3‒9.3

6.5–11.1

6.8–11.0

6.1–12.0

4.1–10.5

4.7–12.7

GLIC

Mean  ±  SD

Median

183.0 ± 60.6

160.0

171.0 ± 38.7

167.0

0.9408

144.7 ± 46.1

131.5

186.9 ± 58.6

172.0

0.0750

139.6 ± 48.3

126.5

167.8 ± 76.9

150.0

0.4074

167.5 ± 63.1

171.0

165.7 ± 63.7

151.0

0.7039

Min.–Max.

117.0–301.0

123.0–243.0

85.0–226.0

12.01‒282.0

96.0–262.0

80.0–359.0

85.0–303.0

72.0–348.0

TC

Mean  ±  SD

Median

194.3 ± 40.3

202.0

226.0 ± 62.9

204.0

0.3422

176.3 ± 37.9

174.0

186.9 ± 46.4

169.0

0.9999

220.8 ± 72.0

206.5

199.0 ± 54.1

187.0

0.5807

195.8 ± 47.4

185.5

178.1 ± 38.8

188.5

0.3495

Min.–Max.

132.0–273.0

159.0–345.0

93.0‒226.0

133.0‒270.0

129.0–320.0

131.0–316.0

127.0–283.0

96.0–238.0

HDL

Mean  ±  SD

Median

44.9 ± 9.8

47.0

40.2 ± 6.4

41.0

0.3050

45.1 ± 9.9

44.0

47.9 ± 10.2

48.0

0.6744

45.9 ± 15.5

49.0

40.1 ± 10.0

39.0

0.4820

40.2 ± 9.7

40.0

48.3 ± 11.1

46.5

0.0273*

Min.–Max.

30.0–57.0

27.0–50.0

30.0‒61.0

32.0‒62.0

29.0–75.0

21.0–57.0

23.0–60.0

30.0 ± 75.0

LDL

Mean  ±  SD

Median

111.7 ± 37.5

112.6

129.6–71.0

103.6

0.9999

106.6 ± 38.9

109.3

102.1 ± 41.4

92.7

0.5824

143.5 ± 63.1

127.4

115.3 ± 5.4

111.0

0.3338

120.0 ± 45.5

116.1

97.5 ± 38.9

101.5

0.1933

Min.–Max.

62.0–177.0

29.0–227.0

29.4‒158.4

52.8—184

65.6–251.6

42.0–215.6

46.8–209.9

30.0–181.0

TRIG

Mean  ±  SD

Median

189.0 ± 93.1

170.0

273.2 ± 177.9

207.0

0.2947

153.7 ± 58.0

146.0

196.2 ± 74.7

201.5

0.1593

157.0 ± 54.7

174.5

231.8 ± 96.9

251.0

0.0459*

191.1 ± 99.3

166.5

177.4 ± 114.3

148.4

0.4385

Min.–Max.

55.0–329.0

82.0–650.0

80.0‒272.0

56.0‒292.0

67.0–243.0

80.0–464.0

67.0–488.0

53.0–484.0

CREA-S

Mean  ±  SD

Median

1.0 ± 0.3

1.0

0.8 ± 0.2

0.9

0.2947

0.9 ± 0.3

0.8

0.6 ± 0.2

0.6

0.0020*

1.2 ± 0.4

1.0

1.0 ± 0.4

1.0

0.5139

0.8 ± 0.3

0.7

0.8 ± 0.4

0.7

0.6089

Min.–Max.

0.5–1.4

0.6–1.1

0.7‒1.7

0.4‒1.2

0.7–2.2

0.5–1.8

0.5–1.8

0.5–2.2

M. ALB

Mean  ±  SD

Median

60.2 ± 60.0

43.0

102.8 ± 207.0

25.0

0.8238

8.2 ± 7.5

7.2

8.1 ± 8.2

4.6

0.9737

180.4 ± 216.7

52.0

126.0 ± 203.1

42.5

0.5701

9.3 ± 8.8

6.6

8.6 ± 8.7

4.0

0.3719

Min.–Max.

3.0–205.0

1.0–650.0

1.0‒24.0

1.0‒26.0

1.0–525.0

4.1–650.0

1.0–28.0

1.0–22.0

CRP

Mean  ±  SD

Median

3.8 ± 3.7

2.6

5.0 ± 2.5

6.4

0.2110

3.3 ± 2.5

2.5

3.1 ± 3.7

2.0

0.5387

3.6 ± 3.3

2.2

3.0 ± 3.2

1.8

0.3595

4.0 ± 3.8

3.6

2.9 ± 3.0

2.1

0.3571

Min.–Max.

0.6–11.9

1.2–7.7

0.6–9.5

0.4–13.3

0.9–11.5

0.4–9.6

0.3–11.7

0.1–11.6

AGP

Mean  ±  SD

Median

101.9 ± 59.3

89.5

84.6 ± 11.7

84.0

0.7131

90.0 ± 23.2

89.5

83.0 ± 18.0

82.5

0.5387

82.3 ± 32.5

75.0

70.7 ± 38.5

68.0

0.2186

80.2 ± 16.7

74.5

76.3 ± 23.5

77.5

0.6504

Min.–Max.

57.0–263.0

68.0–102.0

55.0–140.0

56.0–118.0

60.0–172.0

16.0–176.0

52.0–121.0

4.0–111.0

TAC

Mean  ±  SD

Median

51.0 ± 19.0

52.5

32.6 ± 32.4

13.0

0.1564

57.5 ± 30.7

64.5

48.2 ± 27.5

47.5

0.5387

31.4 ± 26.1

22.0

14.6 ± 11.2

11.0

0.0195*

25.7 ± 29.1

12.0

33.2 ± 27.4

15.5

0.2728

Min.–Max.

15.0–75.0

9.0–87.0

8.0–94.0

5.0–91.0

8.0–80.0

2.0–44.0

4.0–96.0

6.0–82.0

MDA

Mean  ±  SD

Median

3.3 ± 1.4

3.8

3.5 ± 0.8

3.6

0.9013

3.9 ± 0.6

3.7

3.9 ± 0.7

4.0

0.9474

3.6 ± 1.4

3.3

3.4 ± 1.6

3.7

0.7632

3.4 ± 1.2

3.6

3.4 ± 1.1

3.6

0.9185

Min.–Max.

1.1–4.8

2.3–4.8

3.2–5.1

2.8–4.9

1.7–6.3

1.0–6.2

1.4–5.6

1.5–5.3

  1. HbA1C (%) glycated haemoglobin, GLIC (mg/dL) fasting glycemia, TC (mg/dL) total cholesterol, HDL (mg/dL) high density lipoprotein, LDL (mg/dL) light density lipoprotein cholesterol, TRIG (mg/dL) triglycerides, CREA-S (mg/dL) serum creatinine, M. ALB (mg/dL) 24 h albumin excreted in the urine, RCP (mg/dL) reactive C protein, AGP (mg/dL) alfa 1 acid glycoprotein, TAC (%) total antioxidant capacity, MDA (µM) malondialdehyde
  2. * Statistically significant (p < 0.05), Mann–Whitney test