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Table 5 Analysis of the relationship between the MTHFR methylation pattern and the C677C polymorphism of MTHFR and biochemical, inflammatory and oxidative stress variables associated with clinical condition

From: The MTHFR promoter hypermethylation pattern associated with the A1298C polymorphism influences lipid parameters and glycemic control in diabetic patients

  With complications (20) Control (22) With complications (27) Control (38)
Methylated CC (11) MethylatedTC (6) + TT (3) p Methylated CC (10) Methylated TC (12) p Partially Methylated CC (10) Partially MethylatedTC (16) + TT (1) p Partially Methylated CC (20) Partially MethylatedTC (17) + TT (1) p
HbA1c Mean  ±  SD
Median
9.7 ± 2.9
9.0
7.8 ± 1.1
7.7
0.3231 7.2 ± 1.3
7.2
8.1 ± 1.3
8.0
0.1984 8.4 ± 1.4
8.2
8.6 ± 1.8
8.0
0.9399 8.2 ± 1.9
8.3
8.0 ± 2.1
7.6
0.5785
Min.–Max. 6.4–14.4 5.7–9.6 5.3‒9.3 6.5–11.1 6.8–11.0 6.1–12.0 4.1–10.5 4.7–12.7
GLIC Mean  ±  SD
Median
183.0 ± 60.6
160.0
171.0 ± 38.7
167.0
0.9408 144.7 ± 46.1
131.5
186.9 ± 58.6
172.0
0.0750 139.6 ± 48.3
126.5
167.8 ± 76.9
150.0
0.4074 167.5 ± 63.1
171.0
165.7 ± 63.7
151.0
0.7039
Min.–Max. 117.0–301.0 123.0–243.0 85.0–226.0 12.01‒282.0 96.0–262.0 80.0–359.0 85.0–303.0 72.0–348.0
TC Mean  ±  SD
Median
194.3 ± 40.3
202.0
226.0 ± 62.9
204.0
0.3422 176.3 ± 37.9
174.0
186.9 ± 46.4
169.0
0.9999 220.8 ± 72.0
206.5
199.0 ± 54.1
187.0
0.5807 195.8 ± 47.4
185.5
178.1 ± 38.8
188.5
0.3495
Min.–Max. 132.0–273.0 159.0–345.0 93.0‒226.0 133.0‒270.0 129.0–320.0 131.0–316.0 127.0–283.0 96.0–238.0
HDL Mean  ±  SD
Median
44.9 ± 9.8
47.0
40.2 ± 6.4
41.0
0.3050 45.1 ± 9.9
44.0
47.9 ± 10.2
48.0
0.6744 45.9 ± 15.5
49.0
40.1 ± 10.0
39.0
0.4820 40.2 ± 9.7
40.0
48.3 ± 11.1
46.5
0.0273*
Min.–Max. 30.0–57.0 27.0–50.0 30.0‒61.0 32.0‒62.0 29.0–75.0 21.0–57.0 23.0–60.0 30.0 ± 75.0
LDL Mean  ±  SD
Median
111.7 ± 37.5
112.6
129.6–71.0
103.6
0.9999 106.6 ± 38.9
109.3
102.1 ± 41.4
92.7
0.5824 143.5 ± 63.1
127.4
115.3 ± 5.4
111.0
0.3338 120.0 ± 45.5
116.1
97.5 ± 38.9
101.5
0.1933
Min.–Max. 62.0–177.0 29.0–227.0 29.4‒158.4 52.8—184 65.6–251.6 42.0–215.6 46.8–209.9 30.0–181.0
TRIG Mean  ±  SD
Median
189.0 ± 93.1
170.0
273.2 ± 177.9
207.0
0.2947 153.7 ± 58.0
146.0
196.2 ± 74.7
201.5
0.1593 157.0 ± 54.7
174.5
231.8 ± 96.9
251.0
0.0459* 191.1 ± 99.3
166.5
177.4 ± 114.3
148.4
0.4385
Min.–Max. 55.0–329.0 82.0–650.0 80.0‒272.0 56.0‒292.0 67.0–243.0 80.0–464.0 67.0–488.0 53.0–484.0
CREA-S Mean  ±  SD
Median
1.0 ± 0.3
1.0
0.8 ± 0.2
0.9
0.2947 0.9 ± 0.3
0.8
0.6 ± 0.2
0.6
0.0020* 1.2 ± 0.4
1.0
1.0 ± 0.4
1.0
0.5139 0.8 ± 0.3
0.7
0.8 ± 0.4
0.7
0.6089
Min.–Max. 0.5–1.4 0.6–1.1 0.7‒1.7 0.4‒1.2 0.7–2.2 0.5–1.8 0.5–1.8 0.5–2.2
M. ALB Mean  ±  SD
Median
60.2 ± 60.0
43.0
102.8 ± 207.0
25.0
0.8238 8.2 ± 7.5
7.2
8.1 ± 8.2
4.6
0.9737 180.4 ± 216.7
52.0
126.0 ± 203.1
42.5
0.5701 9.3 ± 8.8
6.6
8.6 ± 8.7
4.0
0.3719
Min.–Max. 3.0–205.0 1.0–650.0 1.0‒24.0 1.0‒26.0 1.0–525.0 4.1–650.0 1.0–28.0 1.0–22.0
CRP Mean  ±  SD
Median
3.8 ± 3.7
2.6
5.0 ± 2.5
6.4
0.2110 3.3 ± 2.5
2.5
3.1 ± 3.7
2.0
0.5387 3.6 ± 3.3
2.2
3.0 ± 3.2
1.8
0.3595 4.0 ± 3.8
3.6
2.9 ± 3.0
2.1
0.3571
Min.–Max. 0.6–11.9 1.2–7.7 0.6–9.5 0.4–13.3 0.9–11.5 0.4–9.6 0.3–11.7 0.1–11.6
AGP Mean  ±  SD
Median
101.9 ± 59.3
89.5
84.6 ± 11.7
84.0
0.7131 90.0 ± 23.2
89.5
83.0 ± 18.0
82.5
0.5387 82.3 ± 32.5
75.0
70.7 ± 38.5
68.0
0.2186 80.2 ± 16.7
74.5
76.3 ± 23.5
77.5
0.6504
Min.–Max. 57.0–263.0 68.0–102.0 55.0–140.0 56.0–118.0 60.0–172.0 16.0–176.0 52.0–121.0 4.0–111.0
TAC Mean  ±  SD
Median
51.0 ± 19.0
52.5
32.6 ± 32.4
13.0
0.1564 57.5 ± 30.7
64.5
48.2 ± 27.5
47.5
0.5387 31.4 ± 26.1
22.0
14.6 ± 11.2
11.0
0.0195* 25.7 ± 29.1
12.0
33.2 ± 27.4
15.5
0.2728
Min.–Max. 15.0–75.0 9.0–87.0 8.0–94.0 5.0–91.0 8.0–80.0 2.0–44.0 4.0–96.0 6.0–82.0
MDA Mean  ±  SD
Median
3.3 ± 1.4
3.8
3.5 ± 0.8
3.6
0.9013 3.9 ± 0.6
3.7
3.9 ± 0.7
4.0
0.9474 3.6 ± 1.4
3.3
3.4 ± 1.6
3.7
0.7632 3.4 ± 1.2
3.6
3.4 ± 1.1
3.6
0.9185
Min.–Max. 1.1–4.8 2.3–4.8 3.2–5.1 2.8–4.9 1.7–6.3 1.0–6.2 1.4–5.6 1.5–5.3
  1. HbA1C (%) glycated haemoglobin, GLIC (mg/dL) fasting glycemia, TC (mg/dL) total cholesterol, HDL (mg/dL) high density lipoprotein, LDL (mg/dL) light density lipoprotein cholesterol, TRIG (mg/dL) triglycerides, CREA-S (mg/dL) serum creatinine, M. ALB (mg/dL) 24 h albumin excreted in the urine, RCP (mg/dL) reactive C protein, AGP (mg/dL) alfa 1 acid glycoprotein, TAC (%) total antioxidant capacity, MDA (µM) malondialdehyde
  2. * Statistically significant (p < 0.05), Mann–Whitney test