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Table 4 Analysis of the relationship between the MTHFR methylation pattern and the C677T polymorphism of MTHFR and biochemical, inflammatory and oxidative stress variables

From: The MTHFR promoter hypermethylation pattern associated with the A1298C polymorphism influences lipid parameters and glycemic control in diabetic patients

  Methylated (42) Partially methylated (65)
CC (21) TC (18) + TT (3) p CC (30) TC (33) + TT (2) p
GLIC Mean  ±  SD
Median
164.8 ± 56.3
139.0
180.1 ± 50.5
167.0
0.2273 158.2 ± 59.3
147.0
166.7 ± 69.4
152.0
0.6499
Min.–Max. 85.0–301.0 121.0–282.0 85.0–303.0 72.0–359.0
HbA1c Mean  ±  SD
Median
8.5 ± 2.6
7.9
8.0 ± 1.2
8.0
0.9599 8.3 ± 1.7
8.3
8.3 ± 2.0
8.0
0.8332
Min.–Max. 5.3–14.4 5.7–11.1 4.1–110 4.7–12.7
TC Mean  ±  SD
Median
185.8 ± 39.3
93.0
203.7 ± 56.2
133.0
0.5629 204.1 ± 56.8
187.0
188.2 ± 47.4
187.0
0.3570
Min.–Max. 93.0–272.0 133.0–145.0 127.0–320.0 96.0–316.0
HDL Mean  ±  SD
Median
45.0 ± 9.6
46.0
44.6 ± 9.4
43.0
0.8800 42.1 ± 12.0
41.5
44.3 ± 11.2
43.0
0.3569
Min.–Max. 30.0–61.0 27.0–62.0 23.0–75.0 21.0–75.0
LDL Mean  ±  SD
Median
109.3 ± 37.4
112.6
113.9 ± 56.1
103.6
0.9398 127.8 ± 52.2
117.5
106.2 ± 47.8
101.8
0.1388
Min.–Max. 29.4–177.0 29.0–227.0 46.8–251.6 30.0–215.6
TRIG Mean  ±  SD
Median
172.2 ± 78.6
165.0
229.2 ± 131.4
207.0
0.1189 179.7 ± 87.5
170.5
203.8 ± 108.2
181.0
0.4454
Min.–Max. 55.0–329.0 56.0–650.0 67.0–488.0 53.0–484.0
CREA-S Mean  ±  SD
Median
1.0 ± 0.3 0.7 ± 0.2 0.0080* 0.9 ± 0.4
0.8
0.9 ± 0.4
0.8
0.7372
Min.–Max. 0.5–1.8 0.4–1.2 0.5–2.2 0.5–2.2
M. ALB Mean  ±  SD
Median
35.5 ± 50.4
15.0
48.7 ± 139.6
13.0
0.5627 66.4 ± 146.2
11.0
65.7 ± 151.7
18.0
0.8025
Min.–Max. 1.0–205.0 1.0–650.0 1.0–525.0 1.0–650.0
CRP Mean  ±  SD
Median
3.6 ± 3.1
2.5
3.9 ± 3.3
4.1
0.8144 3.9 ± 3.6
2.8
3.0 ± 3.0
1.8
0.2496
Min.–Max. 0.6–11.9 0.4–13.3 0.3–11.7 0.1–11.7
AGP Mean  ±  SD
Median
96.0 ± 44.3
89.5
83.7 ± 15.3
84.0
0.4652 80.9 ± 22.6
75.0
73.6 ± 31.3
70.0
0.2089
Min.–Max. 55.0–263.0 56.0–118.0 52.0–172.0 4.0–176.0
TAC Mean  ±  SD
Median
54.2 ± 25.1
57.0
41.5 ± 29.9
42.0
0.2458 27.6 ± 27.8
13.0
24.2 ± 22.9
12.0
0.6262
Min.–Max. 8.0–94.0 5.0–91.0 4.0–96.0 2.0–82.0
MDA Mean  ±  SD
Median
3.6 ± 1.1
3.7
3.7 ± 0.8
3.7
0.7916 3.5 ± 1.3
3.4
3.4 ± 1.3
3.7
0.8642
Min.–Max. 1.1–5.1 2.3–4.9 1.4–6.3 1.0–6.2
  1. HbA1C (%) glycated haemoglobin, GLIC (mg/dL) fasting glycemia, TC (mg/dL) total cholesterol, HDL (mg/dL) high density lipoprotein, LDL (mg/dL) light density lipoprotein cholesterol, TRIG (mg/dL) triglycerides, CREA-S (mg/dL) serum creatinine, M. ALB (mg/dL) 24 h albumin excreted in the urine, RCP (mg/dL) reactive C protein, AGP (mg/dL) alfa 1 acid glycoprotein, TAC (%) total antioxidant capacity, MDA (µM) malondialdehyde
  2. * Statistically significant (p < 0.05), Mann–Whitney test