Table 4 Analysis of the relationship between the MTHFR methylation pattern and the C677T polymorphism of MTHFR and biochemical, inflammatory and oxidative stress variables
Methylated (42) | Partially methylated (65) | ||||||
|---|---|---|---|---|---|---|---|
CC (21) | TC (18) + TT (3) | p | CC (30) | TC (33) + TT (2) | p | ||
GLIC | Mean ± SD Median | 164.8 ± 56.3 139.0 | 180.1 ± 50.5 167.0 | 0.2273 | 158.2 ± 59.3 147.0 | 166.7 ± 69.4 152.0 | 0.6499 |
Min.–Max. | 85.0–301.0 | 121.0–282.0 | 85.0–303.0 | 72.0–359.0 | |||
HbA1c | Mean ± SD Median | 8.5 ± 2.6 7.9 | 8.0 ± 1.2 8.0 | 0.9599 | 8.3 ± 1.7 8.3 | 8.3 ± 2.0 8.0 | 0.8332 |
Min.–Max. | 5.3–14.4 | 5.7–11.1 | 4.1–110 | 4.7–12.7 | |||
TC | Mean ± SD Median | 185.8 ± 39.3 93.0 | 203.7 ± 56.2 133.0 | 0.5629 | 204.1 ± 56.8 187.0 | 188.2 ± 47.4 187.0 | 0.3570 |
Min.–Max. | 93.0–272.0 | 133.0–145.0 | 127.0–320.0 | 96.0–316.0 | |||
HDL | Mean ± SD Median | 45.0 ± 9.6 46.0 | 44.6 ± 9.4 43.0 | 0.8800 | 42.1 ± 12.0 41.5 | 44.3 ± 11.2 43.0 | 0.3569 |
Min.–Max. | 30.0–61.0 | 27.0–62.0 | 23.0–75.0 | 21.0–75.0 | |||
LDL | Mean ± SD Median | 109.3 ± 37.4 112.6 | 113.9 ± 56.1 103.6 | 0.9398 | 127.8 ± 52.2 117.5 | 106.2 ± 47.8 101.8 | 0.1388 |
Min.–Max. | 29.4–177.0 | 29.0–227.0 | 46.8–251.6 | 30.0–215.6 | |||
TRIG | Mean ± SD Median | 172.2 ± 78.6 165.0 | 229.2 ± 131.4 207.0 | 0.1189 | 179.7 ± 87.5 170.5 | 203.8 ± 108.2 181.0 | 0.4454 |
Min.–Max. | 55.0–329.0 | 56.0–650.0 | 67.0–488.0 | 53.0–484.0 | |||
CREA-S | Mean ± SD Median | 1.0 ± 0.3 | 0.7 ± 0.2 | 0.0080* | 0.9 ± 0.4 0.8 | 0.9 ± 0.4 0.8 | 0.7372 |
Min.–Max. | 0.5–1.8 | 0.4–1.2 | 0.5–2.2 | 0.5–2.2 | |||
M. ALB | Mean ± SD Median | 35.5 ± 50.4 15.0 | 48.7 ± 139.6 13.0 | 0.5627 | 66.4 ± 146.2 11.0 | 65.7 ± 151.7 18.0 | 0.8025 |
Min.–Max. | 1.0–205.0 | 1.0–650.0 | 1.0–525.0 | 1.0–650.0 | |||
CRP | Mean ± SD Median | 3.6 ± 3.1 2.5 | 3.9 ± 3.3 4.1 | 0.8144 | 3.9 ± 3.6 2.8 | 3.0 ± 3.0 1.8 | 0.2496 |
Min.–Max. | 0.6–11.9 | 0.4–13.3 | 0.3–11.7 | 0.1–11.7 | |||
AGP | Mean ± SD Median | 96.0 ± 44.3 89.5 | 83.7 ± 15.3 84.0 | 0.4652 | 80.9 ± 22.6 75.0 | 73.6 ± 31.3 70.0 | 0.2089 |
Min.–Max. | 55.0–263.0 | 56.0–118.0 | 52.0–172.0 | 4.0–176.0 | |||
TAC | Mean ± SD Median | 54.2 ± 25.1 57.0 | 41.5 ± 29.9 42.0 | 0.2458 | 27.6 ± 27.8 13.0 | 24.2 ± 22.9 12.0 | 0.6262 |
Min.–Max. | 8.0–94.0 | 5.0–91.0 | 4.0–96.0 | 2.0–82.0 | |||
MDA | Mean ± SD Median | 3.6 ± 1.1 3.7 | 3.7 ± 0.8 3.7 | 0.7916 | 3.5 ± 1.3 3.4 | 3.4 ± 1.3 3.7 | 0.8642 |
Min.–Max. | 1.1–5.1 | 2.3–4.9 | 1.4–6.3 | 1.0–6.2 | |||