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Table 3 Analysis of the relationship between the MTHFR methylation pattern and the A1298C polymorphism and biochemical, inflammatory and oxidative stress variables

From: The MTHFR promoter hypermethylation pattern associated with the A1298C polymorphism influences lipid parameters and glycemic control in diabetic patients

  With complications (20) Control (22) With complications (27) Control (38)
Methylated AA (13) Methylated AC (5) + CC (2) p Methylated AA (9) Methylated AC (12) + CC (1) p Partially Methylated AA (17) Partially Methylated AC (9) + CC (1) p Partially Methylated AA (19) Partially Methylated AC (14) + CC (15) p
HbA1c Mean ± SD
Median
8.5 ± 1.9
8.1
9.4 ± 3.2
7.2
> 0.9999 8.6 ± 1.3
8.6
7.2 ± 1.1
7.2
0.0253* 8.3 ±  1.7
8.0
9.0 ± 1.5
9.0
0.2094 7.6 ± 1.9
7.5
8.6 ± 1.9
9.2
0.0932
Min.–Max. 5.7‒13.00 6.9‒14.4 6.7‒11.1 5.3‒9.4 6.1‒12.0 7.1‒11.0 4.1‒12.7 4.3‒11.2
GLIC Mean ± SD
Median
182.2 ± 54.0
160.0
169.0 ± 47.5
172.0
0.7573 191.8 ± 53.0
200.0
151.1 ± 54.3
132.0
0.0489* 153.7 ± 65.2
136.0
163.5 ± 76.1
135.0
0.7065 165.3 ± 57.5
162.0
168.0 ± 68.8
151.0
0.8040
Min.–Max. 123.0‒301.0 117.0‒248.0 121.0‒270.0 85.0‒282.0 80.0‒308.0 97.0‒359.0 72.0‒303.0 85.0 ± 348.0
TC Mean ± SD
Median
230.1 ± 51.0
214.0
168.7 ± 27.6
164
0.0049* 210.7 ± 42.5
200.0
162.3 ± 29.4
162.0
0.0056* 206.5 ± 61.7
187.0
208.0 ± 62.7
209.5
0.9001 185.6 ± 50.9
187.0
189.2 ± 36.9
185.0
0.8040
Min.–Max. 159‒345 132‒211 133.0‒270.0 93.0‒224.0 139.0‒320.0 129.0‒316.0 96.0‒283.0 127.0‒257.0
HDL Mean ± SD
Median
40.3 ± 8.1
39.0
47.3 ± 8.2
47.0
0.1043 48.2 ± 9.7
49.0
45.5 ± 10.4
42.0
0.5258 43.6 ± 12.4
40.0
40.0 ± 12.6
42.0
0.4217 48.4 ± 9.0
58.0
39.7 ± 11.5
39.0
0.0044*
Min.–Max. 27.0‒56.0 33.0‒57.0 32.0‒62.0 30.0‒61.0 30.0‒75.0 21.0‒54.0 33.0‒61.0 23.0‒75.0
LDL Mean ± SD
Median
142.3 ± 54.0
140.4
77.8 ± 18.2
68.4
0.0024* 123.8 ± 38.1
123.0
90.6 ± 35.6
92.0
0.0825 129.8 ± 53.9
118.0
118.8 ± 69.0
116.7
0.2685 109.3 ± 48.1
101.0
109.4 ± 39.6
110.4
0.8153
Min.–Max. 29.0‒227.0 62.0‒112.6 63.4‒184.0 29.4‒158.4 61.8‒218.8 42.0‒251.6 46.8‒209.9 30.0‒181.0
TRIG Mean ± SD
Median
231.5 ± 157.0
200.0
218.3 ± 114.5
172.0
0.8773 193.4 ± 76.3
193.0
165.5 ±  65.0
158.0
0.4310 188.4 ± 77.5
165.0
230.8 ± 108.0
201.5
0.1319 168.4 ± 103.5
146.0
200.8 ± 107.7
168.0
0.2801
Min.–Max. 77.0‒650.0 55.0‒398.0 56.0‒290.0 80.0‒292.0 80.0‒356.0 67.0‒464.0 67.0‒488.0 53.0 ± 484.0
CREA-S Mean ± SD
Median
0.9 ± 0.3
0.9
0.9 ± 0.3
0.8
0.7573 0.7 ± 0.2
0.7
0.8 ± 0.3
0.7
0.9479 1.0 ± 0.3
1.0
1.1 ± 0.5
1.1
0.8018 0.9 ± 0.4
0.7
0.7 ± 0.1
0.7
0.8955
Min.–Max. 0.4‒1.4 0.5 ± 1.3 0.6‒1.2 0.4‒1.8 0.5‒1.8 0.6‒2.2 0.4‒2.2 0.5‒1.0
M. ALB Mean ± SD
Median
99.9 ± 175.1
40.0
41.3 ± 27.2
46.0
0.8773 6.7 ± 6.8
3.0
9.2 ± 8.4
6.0
0.4620 156.8 ± 212.3
46.0
128.2 ± 204.2
33.6
0.3033 10.8 ± 9.2
10.0
7.2 ± 7.9
4.0
0.2992
Min.–Max. 1.0‒650.0 3.0 ± 76.0 1.0‒20.0 1.0‒26.0 7.0‒650.0 1.0‒525.0 1.0‒25.0 1.0‒28.0
CRP Mean ± SD
Median
4.8 ± 3.3
4.9
3.6 ± 2.9
2.1
0.5358 3.4 ± 4.1
2.3
3.1 ±  2.4
2.5
0.6948 3.7 ± 3.8
1.6
2.6 ± 1.8
2.1
0.9411 3.6 ± 3.6
1.9
3.4 ± 3.4
3.3
0.7481
Min.–Max. 0.6‒11.9 1.0‒8.2 0.4‒13.3 0.4‒9.5 0.4‒11.5 0.7‒6.2 0.3‒11.7 0.1‒11.7
AGP Mean ± SD
Median
101.0 ± 51.9
85.0
81.1 ± 21.5
72.0
0.4219 87.0 ± 17.8
87.0
85.6 ± 22.6
84.0
0.7438 72.9 ± 36.1
69.0
78.6 ± 38.1
72.5
0.4820 76.0 ± 22.3
72.0
80.8 ± 16.7
77.0
0.6934
Min.–Max. 72.0‒263.0 57.0‒109.0 59.0‒118.0 55.0‒140.0 16.0‒176.0 21.0‒172.0 4.0‒105.0 52.0‒121.0
TAC Mean ± SD
Median
37.0 ± 24.9
37.0
51.3 ± 30.3
63.0
0.3104 45.8 ± 32.4
42.0
57.0 ± 26.1
59.0
0.4425 15.8 ± 12.4
12.0
29.4 ± 26.5
18.0
0.1079 32.9 ± 31.5
19.0
25.6 ± 24.8
12.0
0.7041
Min.–Max. 9.0‒72.0 9.0‒87.0 5.0‒91.0 8.0‒94.0 2.0‒46.0 8.0‒80.0 6.0‒96.0 4.0‒84.0
MDA Mean ± SD
Median
3.0 ± 1.2
3.4
4.0 ± 0.7
4.1
0.0811 4.1 ± 0.7
4.0
3.9 ± 0.7
3.6
0.3851 3.7 ± 1.3
3.7
3.2 ± 1.7
2.9
0.4821 3.4 ± 1.2
3.8
3.4 ± 1.2
3.4
0.8724
Min.–Max. 1.1‒4.8 3.1‒4.8 2.8‒4.9 3.1‒5.1 1.0‒6.2 1.4‒6.3 1.4‒5.3 1.4‒5.6
  1. HbA1C (%) glycated haemoglobin, GLIC (mg/dL) fasting glycemia, TC (mg/dL) total cholesterol, HDL (mg/dL) high density lipoprotein, LDL (mg/dL) light density lipoprotein cholesterol, TRIG (mg/dL) triglycerides, CREA-S (mg/dL) serum creatinine, M. ALB (mg/dL) 24 h albumin excreted in the urine, RCP (mg/dL) reactive C protein, AGP (mg/dL) alfa 1 acid glycoprotein, TAC (%) total antioxidant capacity, MDA (µM) malondialdehyde
  2. * Statistically significant (p < 0.05), Mann–Whitney test