Table 3 Analysis of the relationship between the MTHFR methylation pattern and the A1298C polymorphism and biochemical, inflammatory and oxidative stress variables
With complications (20) | Control (22) | With complications (27) | Control (38) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Methylated AA (13) | Methylated AC (5) + CC (2) | p | Methylated AA (9) | Methylated AC (12) + CC (1) | p | Partially Methylated AA (17) | Partially Methylated AC (9) + CC (1) | p | Partially Methylated AA (19) | Partially Methylated AC (14) + CC (15) | p | ||
HbA1c | Mean ± SD Median | 8.5 ± 1.9 8.1 | 9.4 ± 3.2 7.2 | > 0.9999 | 8.6 ± 1.3 8.6 | 7.2 ± 1.1 7.2 | 0.0253* | 8.3 ± 1.7 8.0 | 9.0 ± 1.5 9.0 | 0.2094 | 7.6 ± 1.9 7.5 | 8.6 ± 1.9 9.2 | 0.0932 |
Min.–Max. | 5.7‒13.00 | 6.9‒14.4 | 6.7‒11.1 | 5.3‒9.4 | 6.1‒12.0 | 7.1‒11.0 | 4.1‒12.7 | 4.3‒11.2 | |||||
GLIC | Mean ± SD Median | 182.2 ± 54.0 160.0 | 169.0 ± 47.5 172.0 | 0.7573 | 191.8 ± 53.0 200.0 | 151.1 ± 54.3 132.0 | 0.0489* | 153.7 ± 65.2 136.0 | 163.5 ± 76.1 135.0 | 0.7065 | 165.3 ± 57.5 162.0 | 168.0 ± 68.8 151.0 | 0.8040 |
Min.–Max. | 123.0‒301.0 | 117.0‒248.0 | 121.0‒270.0 | 85.0‒282.0 | 80.0‒308.0 | 97.0‒359.0 | 72.0‒303.0 | 85.0 ± 348.0 | |||||
TC | Mean ± SD Median | 230.1 ± 51.0 214.0 | 168.7 ± 27.6 164 | 0.0049* | 210.7 ± 42.5 200.0 | 162.3 ± 29.4 162.0 | 0.0056* | 206.5 ± 61.7 187.0 | 208.0 ± 62.7 209.5 | 0.9001 | 185.6 ± 50.9 187.0 | 189.2 ± 36.9 185.0 | 0.8040 |
Min.–Max. | 159‒345 | 132‒211 | 133.0‒270.0 | 93.0‒224.0 | 139.0‒320.0 | 129.0‒316.0 | 96.0‒283.0 | 127.0‒257.0 | |||||
HDL | Mean ± SD Median | 40.3 ± 8.1 39.0 | 47.3 ± 8.2 47.0 | 0.1043 | 48.2 ± 9.7 49.0 | 45.5 ± 10.4 42.0 | 0.5258 | 43.6 ± 12.4 40.0 | 40.0 ± 12.6 42.0 | 0.4217 | 48.4 ± 9.0 58.0 | 39.7 ± 11.5 39.0 | 0.0044* |
Min.–Max. | 27.0‒56.0 | 33.0‒57.0 | 32.0‒62.0 | 30.0‒61.0 | 30.0‒75.0 | 21.0‒54.0 | 33.0‒61.0 | 23.0‒75.0 | |||||
LDL | Mean ± SD Median | 142.3 ± 54.0 140.4 | 77.8 ± 18.2 68.4 | 0.0024* | 123.8 ± 38.1 123.0 | 90.6 ± 35.6 92.0 | 0.0825 | 129.8 ± 53.9 118.0 | 118.8 ± 69.0 116.7 | 0.2685 | 109.3 ± 48.1 101.0 | 109.4 ± 39.6 110.4 | 0.8153 |
Min.–Max. | 29.0‒227.0 | 62.0‒112.6 | 63.4‒184.0 | 29.4‒158.4 | 61.8‒218.8 | 42.0‒251.6 | 46.8‒209.9 | 30.0‒181.0 | |||||
TRIG | Mean ± SD Median | 231.5 ± 157.0 200.0 | 218.3 ± 114.5 172.0 | 0.8773 | 193.4 ± 76.3 193.0 | 165.5 ± 65.0 158.0 | 0.4310 | 188.4 ± 77.5 165.0 | 230.8 ± 108.0 201.5 | 0.1319 | 168.4 ± 103.5 146.0 | 200.8 ± 107.7 168.0 | 0.2801 |
Min.–Max. | 77.0‒650.0 | 55.0‒398.0 | 56.0‒290.0 | 80.0‒292.0 | 80.0‒356.0 | 67.0‒464.0 | 67.0‒488.0 | 53.0 ± 484.0 | |||||
CREA-S | Mean ± SD Median | 0.9 ± 0.3 0.9 | 0.9 ± 0.3 0.8 | 0.7573 | 0.7 ± 0.2 0.7 | 0.8 ± 0.3 0.7 | 0.9479 | 1.0 ± 0.3 1.0 | 1.1 ± 0.5 1.1 | 0.8018 | 0.9 ± 0.4 0.7 | 0.7 ± 0.1 0.7 | 0.8955 |
Min.–Max. | 0.4‒1.4 | 0.5 ± 1.3 | 0.6‒1.2 | 0.4‒1.8 | 0.5‒1.8 | 0.6‒2.2 | 0.4‒2.2 | 0.5‒1.0 | |||||
M. ALB | Mean ± SD Median | 99.9 ± 175.1 40.0 | 41.3 ± 27.2 46.0 | 0.8773 | 6.7 ± 6.8 3.0 | 9.2 ± 8.4 6.0 | 0.4620 | 156.8 ± 212.3 46.0 | 128.2 ± 204.2 33.6 | 0.3033 | 10.8 ± 9.2 10.0 | 7.2 ± 7.9 4.0 | 0.2992 |
Min.–Max. | 1.0‒650.0 | 3.0 ± 76.0 | 1.0‒20.0 | 1.0‒26.0 | 7.0‒650.0 | 1.0‒525.0 | 1.0‒25.0 | 1.0‒28.0 | |||||
CRP | Mean ± SD Median | 4.8 ± 3.3 4.9 | 3.6 ± 2.9 2.1 | 0.5358 | 3.4 ± 4.1 2.3 | 3.1 ± 2.4 2.5 | 0.6948 | 3.7 ± 3.8 1.6 | 2.6 ± 1.8 2.1 | 0.9411 | 3.6 ± 3.6 1.9 | 3.4 ± 3.4 3.3 | 0.7481 |
Min.–Max. | 0.6‒11.9 | 1.0‒8.2 | 0.4‒13.3 | 0.4‒9.5 | 0.4‒11.5 | 0.7‒6.2 | 0.3‒11.7 | 0.1‒11.7 | |||||
AGP | Mean ± SD Median | 101.0 ± 51.9 85.0 | 81.1 ± 21.5 72.0 | 0.4219 | 87.0 ± 17.8 87.0 | 85.6 ± 22.6 84.0 | 0.7438 | 72.9 ± 36.1 69.0 | 78.6 ± 38.1 72.5 | 0.4820 | 76.0 ± 22.3 72.0 | 80.8 ± 16.7 77.0 | 0.6934 |
Min.–Max. | 72.0‒263.0 | 57.0‒109.0 | 59.0‒118.0 | 55.0‒140.0 | 16.0‒176.0 | 21.0‒172.0 | 4.0‒105.0 | 52.0‒121.0 | |||||
TAC | Mean ± SD Median | 37.0 ± 24.9 37.0 | 51.3 ± 30.3 63.0 | 0.3104 | 45.8 ± 32.4 42.0 | 57.0 ± 26.1 59.0 | 0.4425 | 15.8 ± 12.4 12.0 | 29.4 ± 26.5 18.0 | 0.1079 | 32.9 ± 31.5 19.0 | 25.6 ± 24.8 12.0 | 0.7041 |
Min.–Max. | 9.0‒72.0 | 9.0‒87.0 | 5.0‒91.0 | 8.0‒94.0 | 2.0‒46.0 | 8.0‒80.0 | 6.0‒96.0 | 4.0‒84.0 | |||||
MDA | Mean ± SD Median | 3.0 ± 1.2 3.4 | 4.0 ± 0.7 4.1 | 0.0811 | 4.1 ± 0.7 4.0 | 3.9 ± 0.7 3.6 | 0.3851 | 3.7 ± 1.3 3.7 | 3.2 ± 1.7 2.9 | 0.4821 | 3.4 ± 1.2 3.8 | 3.4 ± 1.2 3.4 | 0.8724 |
Min.–Max. | 1.1‒4.8 | 3.1‒4.8 | 2.8‒4.9 | 3.1‒5.1 | 1.0‒6.2 | 1.4‒6.3 | 1.4‒5.3 | 1.4‒5.6 | |||||