Table 2 Analysis of the association between the MTHF methylation profile and A1298C polymorphism of MTHFR and the biochemical, inflammatory and oxidative stress variables
Methylated (42) | Partially methylated (65) | ||||||
|---|---|---|---|---|---|---|---|
AA (22) | AC (17) + CC (3) | p | AA (36) | AC (23) + CC (6) | p | ||
HbA1c | Mean ± SD Median | 8.6 ± 1.7 8.4 | 7.9 ± 2.3 7.2 | 0.0718 | 7.9 ± 1.8 7.6 | 8.7 ± 1.8 9.0 | 0.0516 |
Min.–Max. | 5.7–13.0 | 5.3–14.4 | 4.1–12.7 | 4.3–11.2 | |||
GLIC | Mean ± SD Median | 186.1 ± 52.5 163.5 | 157.4 ± 51.5 135.0 | 0.0366* | 159.8 ± 60.7 151.0 | 166.4 ± 70.0 145.0 | 0.8794 |
Min.–Max. | 121.0–301.0 | 85.0–282.0 | 72.0–308.0 | 85.0 ± 359.0 | |||
TC | Mean ± SD Median | 222.1 ± 47.6 214.3 | 164.6 ± 28.3 163.0 | 0.0001* | 195.5 ± 56.5 187.0 | 195.7 ± 47.1 192.0 | 0.8225 |
Min.–Max. | 133.0–345.0 | 93.0–224.0 | 96.0 ± 320.0 | 127.0–316.0 | |||
HDL | Mean ± SD Median | 43.6 ± 9.4 42.0 | 46.1 ± 9.5 45.0 | 0.3918 | 46.1 ± 10.8 45.0 | 39.8 ± 11.6 39.0 | 0.0179* |
Min.–Max. | 27.0–62.0 | 30.0–61.0 | 30.0–75.0 | 21.0–75.0 | |||
LDL | Mean ± SD Median | 134.8 ± 48.0 131.7 | 86.1 ± 30.7 84.7 | 0.0006* | 119.0 ± 51.2 114.5 | 112.6 ± 50.6 110.4 | 0.7565 |
Min.–Max. | 29.0–227.0 | 29.4–158.4 | 46.8 ± 218.8 | 30.0–251.6 | |||
TRIG | Mean ± SD Median | 216.0 ± 129.1 196.5 | 184.0 ± 86.4 165.5 | 0.4350 | 177.8 ± 91.4 158.0 | 211.2 ± 106.8 177.0 | 0.1937 |
Min.–Max. | 56.0–650.0 | 55.0–398.0 | 67.0–488.0 | 53.0–484.0 | |||
CREA-S | Mean ± SD Median | 0.8 ± 0.3 0.8 | 0.8 ± 0.3 0.8 | 0.7529 | 0.9 ± 0.4 0.8 | 0.9 ± 0.3 0.8 | 0.4362 |
Min.–Max. | 0.4–1.4 | 0.4–1.7 | 0.5–2.2 | 0.5–2.2 | |||
M. ALB | Mean ± SD Median | 61.7 ± 140.5 18.0 | 20.4 ± 22.9 9.3 | 0.4651 | 79.8 ± 161.6 21.3 | 48.9 ± 129.9 7.2 | 0.0705 |
Min.–Max. | 1.0–650.0 | 1.0–76.0 | 1.0–650.0 | 1.0–525.0 | |||
RCP | Mean ± SD Median | 4.2 ± 3.7 3.8 | 3.3 ± 2.5 2.5 | 0.5839 | 3.6 ± 3.6 1.8 | 3.1 ± 2.9 2.2 | 0.7766 |
Min.–Max. | 0.4–13.3 | 0.4–9.5 | 0.3 ± 11.7 | 0.1–11.7 | |||
AGP | Mean ± SD Median | 95.0 ± 40.8 86.0 | 84.0–21.8 83.0 | 0.4652 | 74.5 ± 29.2 71.0 | 80.0 ± 25.8 76.0 | 0.3454 |
Min.–Max. | 59.0–263.0 | 55.0–140.0 | 4.0–176.0 | 21.0–172.0 | |||
TAC | Mean ± SD Median | 40.8 ± 28.0 42.0 | 55.0 ± 27.0 61.0 | 0.1337 | 24.8 ± 25.6 12.0 | 26.9 ± 25.0 13.0 | 0.4800 |
Min.–Max. | 5.0–91.0 | 8.0–94.0 | 2.0–96.0 | 4.0–84.0 | |||
MDA | Mean ± SD Median | 3.4 ± 1.1 3.7 | 3.9 ± 0.6 3.7 | 0.3579 | 3.5 ± 1.3 3.7 | 3.3 ± 1.4 3.4 | 0.4843 |
Min.–Max. | 1.1–4.9 | 3.1–5.1 | 1.0–6.2 | 1.4–6.3 | |||