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Table 2 Analysis of the association between the MTHF methylation profile and A1298C polymorphism of MTHFR and the biochemical, inflammatory and oxidative stress variables

From: The MTHFR promoter hypermethylation pattern associated with the A1298C polymorphism influences lipid parameters and glycemic control in diabetic patients

  Methylated (42) Partially methylated (65)
AA (22) AC (17) + CC (3) p AA (36) AC (23) + CC (6) p
HbA1c Mean  ±  SD
Median
8.6 ± 1.7
8.4
7.9 ± 2.3
7.2
0.0718 7.9 ± 1.8
7.6
8.7 ± 1.8
9.0
0.0516
Min.–Max. 5.7–13.0 5.3–14.4 4.1–12.7 4.3–11.2
GLIC Mean  ±  SD
Median
186.1 ± 52.5
163.5
157.4 ± 51.5
135.0
0.0366* 159.8 ± 60.7
151.0
166.4 ± 70.0
145.0
0.8794
Min.–Max. 121.0–301.0 85.0–282.0 72.0–308.0 85.0 ± 359.0
TC Mean  ±  SD
Median
222.1 ± 47.6
214.3
164.6 ± 28.3
163.0
0.0001* 195.5 ± 56.5
187.0
195.7 ± 47.1
192.0
0.8225
Min.–Max. 133.0–345.0 93.0–224.0 96.0 ± 320.0 127.0–316.0
HDL Mean  ±  SD
Median
43.6 ± 9.4
42.0
46.1 ± 9.5
45.0
0.3918 46.1 ± 10.8
45.0
39.8 ± 11.6
39.0
0.0179*
Min.–Max. 27.0–62.0 30.0–61.0 30.0–75.0 21.0–75.0
LDL Mean  ±  SD
Median
134.8 ± 48.0
131.7
86.1 ± 30.7
84.7
0.0006* 119.0 ± 51.2
114.5
112.6 ± 50.6
110.4
0.7565
Min.–Max. 29.0–227.0 29.4–158.4 46.8 ± 218.8 30.0–251.6
TRIG Mean  ±  SD
Median
216.0 ± 129.1
196.5
184.0 ± 86.4
165.5
0.4350 177.8 ± 91.4
158.0
211.2 ± 106.8
177.0
0.1937
Min.–Max. 56.0–650.0 55.0–398.0 67.0–488.0 53.0–484.0
CREA-S Mean  ±  SD
Median
0.8 ± 0.3
0.8
0.8 ± 0.3
0.8
0.7529 0.9 ± 0.4
0.8
0.9 ± 0.3
0.8
0.4362
Min.–Max. 0.4–1.4 0.4–1.7 0.5–2.2 0.5–2.2
M. ALB Mean  ±  SD
Median
61.7 ± 140.5
18.0
20.4 ± 22.9
9.3
0.4651 79.8 ± 161.6
21.3
48.9 ± 129.9
7.2
0.0705
Min.–Max. 1.0–650.0 1.0–76.0 1.0–650.0 1.0–525.0
RCP Mean  ±  SD
Median
4.2 ± 3.7
3.8
3.3 ± 2.5
2.5
0.5839 3.6 ± 3.6
1.8
3.1 ± 2.9
2.2
0.7766
Min.–Max. 0.4–13.3 0.4–9.5 0.3 ± 11.7 0.1–11.7
AGP Mean  ±  SD
Median
95.0 ± 40.8
86.0
84.0–21.8
83.0
0.4652 74.5 ± 29.2
71.0
80.0 ± 25.8
76.0
0.3454
Min.–Max. 59.0–263.0 55.0–140.0 4.0–176.0 21.0–172.0
TAC Mean  ±  SD
Median
40.8 ± 28.0
42.0
55.0 ± 27.0
61.0
0.1337 24.8 ± 25.6
12.0
26.9 ± 25.0
13.0
0.4800
Min.–Max. 5.0–91.0 8.0–94.0 2.0–96.0 4.0–84.0
MDA Mean  ±  SD
Median
3.4 ± 1.1
3.7
3.9 ± 0.6
3.7
0.3579 3.5 ± 1.3
3.7
3.3 ± 1.4
3.4
0.4843
Min.–Max. 1.1–4.9 3.1–5.1 1.0–6.2 1.4–6.3
  1. HbA1C (%) glycated haemoglobin, GLIC (mg/dL) fasting glycemia, TC (mg/dL) total cholesterol, HDL (mg/dL) high density lipoprotein, LDL (mg/dL) light density lipoprotein cholesterol, TRIG (mg/dL) triglycerides, CREA-S (mg/dL) serum creatinine, M. ALB (mg/dL) 24 h albumin excreted in the urine, RCP (mg/dL) reactive C protein, AGP (mg/dL) alfa 1 acid glycoprotein, TAC (%) total antioxidant capacity, MDA (µM) malondialdehyde
  2. * Statistically significant (p < 0.05), Mann–Whitney test