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Table 2 Multivariate analysis of cancer mortality with the number of metabolic syndrome components

From: Metabolic syndrome is a risk factor for cancer mortality in the general Japanese population: the Jichi Medical School Cohort Study

  Participants Cancer deaths Person-years Crude mortality (/1000 person-years) Total HR-ageb (95% CI) Total HR-allc (95% CI) Men HR-allc (95% CI) Women HR-allc (95% CI)
No. of metabolic risk factorsa
 0 3439 173 64,584 2.7 1.00 1.00 1.00 1.00
 1 4111 269 75,684 3.6 1.02 (0.84–1.24) 0.92 (0.76–1.12) 0.95 (0.73–1.23) 0.88 (0.64–1.20)
 2 2628 212 48,329 4.4 1.17 (0.95–1.43) 1.10 (0.89–1.36) 1.14 (0.87–1.49) 1.04 (0.74–1.46)
 3 1149 90 21,050 4.3 1.23 (0.95–1.59) 1.19 (0.92–1.55) 1.08 (0.76–1.54) 1.37 (0.92–2.05)
 4 196 26 3512 7.4 2.14 (1.41–3.23) 1.91 (1.23–2.96) 1.68 (0.95–2.95) 2.32 (1.16–4.66)
P for trend      0.002 0.007 0.103 0.027
Combination of obesity and 3 other risk factors         
 Non-obesity and 0–1 risk factors 7077 422 131,208 3.2 1.00 1.00 1.00 1.00
 Non-obesity and 2 risk factors 1451 136 26,162 5.2 1.25 (1.03–1.52) 1.18 (0.97–1.45) 1.28 (1.02–1.62) 0.89 (0.60–1.34)
 Non-obesity and 3 risk factors 201 15 3499 4.3 1.04 (0.62–1.74) 0.98 (0.57–1.67) 0.99 (0.53–1.88) 0.90 (0.34–2.45)
 Obesity and 0–1 risk factors 1650 96 31,268 3.1 0.93 (0.74–1.16) 1.04 (0.82–1.32) 0.85 (0.58–1.22) 1.28 (0.93–1.76)
 Obesity and 2 risk factors 948 75 17,560 4.3 1.24 (0.97–1.59) 1.32 (1.02–1.71) 1.14 (0.80–1.61) 1.61 (1.10–2.36)
 Obesity and 3 risk factors 196 26 3512 7.4 2.08 (1.40–3.10) 1.99 (1.31–3.04) 1.71 (0.99–2.95) 2.50 (1.27–4.92)
  1. HR hazard ratio, CI confidence interval
  2. aThe 4 components of being obesity, having an elevated blood pressure, elevated plasma glucose, and dyslipidemia
  3. bHazard ratios adjusted for age
  4. cHazard ratios adjusted for age, smoking status (never, past, or current smoker), alcohol drinking status (never, past, or current drinker), marital status (yes or no), educational attainment (≤ 15, 16–18, or ≥ 19 years), physical activity (low, middle, high), occupation category (white-collar, blue-collar, or no working), and menopausal status (pre or post) only in women