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Table 2 Multivariate analysis of cancer mortality with the number of metabolic syndrome components

From: Metabolic syndrome is a risk factor for cancer mortality in the general Japanese population: the Jichi Medical School Cohort Study

 

Participants

Cancer deaths

Person-years

Crude mortality (/1000 person-years)

Total HR-ageb (95% CI)

Total HR-allc (95% CI)

Men HR-allc (95% CI)

Women HR-allc (95% CI)

No. of metabolic risk factorsa

 0

3439

173

64,584

2.7

1.00

1.00

1.00

1.00

 1

4111

269

75,684

3.6

1.02 (0.84–1.24)

0.92 (0.76–1.12)

0.95 (0.73–1.23)

0.88 (0.64–1.20)

 2

2628

212

48,329

4.4

1.17 (0.95–1.43)

1.10 (0.89–1.36)

1.14 (0.87–1.49)

1.04 (0.74–1.46)

 3

1149

90

21,050

4.3

1.23 (0.95–1.59)

1.19 (0.92–1.55)

1.08 (0.76–1.54)

1.37 (0.92–2.05)

 4

196

26

3512

7.4

2.14 (1.41–3.23)

1.91 (1.23–2.96)

1.68 (0.95–2.95)

2.32 (1.16–4.66)

P for trend

    

0.002

0.007

0.103

0.027

Combination of obesity and 3 other risk factors

        

 Non-obesity and 0–1 risk factors

7077

422

131,208

3.2

1.00

1.00

1.00

1.00

 Non-obesity and 2 risk factors

1451

136

26,162

5.2

1.25 (1.03–1.52)

1.18 (0.97–1.45)

1.28 (1.02–1.62)

0.89 (0.60–1.34)

 Non-obesity and 3 risk factors

201

15

3499

4.3

1.04 (0.62–1.74)

0.98 (0.57–1.67)

0.99 (0.53–1.88)

0.90 (0.34–2.45)

 Obesity and 0–1 risk factors

1650

96

31,268

3.1

0.93 (0.74–1.16)

1.04 (0.82–1.32)

0.85 (0.58–1.22)

1.28 (0.93–1.76)

 Obesity and 2 risk factors

948

75

17,560

4.3

1.24 (0.97–1.59)

1.32 (1.02–1.71)

1.14 (0.80–1.61)

1.61 (1.10–2.36)

 Obesity and 3 risk factors

196

26

3512

7.4

2.08 (1.40–3.10)

1.99 (1.31–3.04)

1.71 (0.99–2.95)

2.50 (1.27–4.92)

  1. HR hazard ratio, CI confidence interval
  2. aThe 4 components of being obesity, having an elevated blood pressure, elevated plasma glucose, and dyslipidemia
  3. bHazard ratios adjusted for age
  4. cHazard ratios adjusted for age, smoking status (never, past, or current smoker), alcohol drinking status (never, past, or current drinker), marital status (yes or no), educational attainment (≤ 15, 16–18, or ≥ 19 years), physical activity (low, middle, high), occupation category (white-collar, blue-collar, or no working), and menopausal status (pre or post) only in women