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Table 3 Evaluation of the hypothalamic–pituitary–adrenal axis in the six patients with a clinical diagnosis of FPL syndrome

From: Evaluation of the hypothalamic–pituitary–adrenal axis in a case series of familial partial lipodystrophy

Variable P1 P2 P3 P4 P5 P6
Basal cortisol (µg/dL) 10.3 5.4 9.0 6.4 9.1 7.6
Basal ACTH (pg/mL) 16.3 9.8 12.7 8.2 5.2 17.1
CBG (µg/L) 36.6 28.3 42.4 57.4 65.0 42.2
UFC (µg/24 h)a 45.7 ± 10.0 36.3 ± 8.5 31.5 ± 9.0 50.4 ± 21.0 10.4 ± 4.8 31.2 ± 11.5
Salivary cortisol (nmol/L) 2.9 9.4 5.9 4.3 8.4 5.0
PDC 0.5 mg (µg/dL) 0.5 1.0 1.1 2.9 1.5 0.7
PDC 1 mg (µg/dL) 0.5 0.3 0.7 1.0 1.5 0.5
  1. Reference values: basal cortisol: 3.7–19.4 µg/dL; ACTH 7.2–63.3 pg/mL; CBG male: 25–55/female: 40–154 µg/L; UFC: 4.3–176 µg/24 h; nocturnal salivary cortisol < 9.7 nmol/L; and CPD < 0.8 µg/dL
  2. ACTH adrenocorticotrophic hormone, CBG cortisol binding globulin, UFC urinary free cortisol, PDC post-dexamethasone cortisol
  3. aMean ± values from three independent measurements