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Table 3 Evaluation of the hypothalamic–pituitary–adrenal axis in the six patients with a clinical diagnosis of FPL syndrome

From: Evaluation of the hypothalamic–pituitary–adrenal axis in a case series of familial partial lipodystrophy

Variable

P1

P2

P3

P4

P5

P6

Basal cortisol (µg/dL)

10.3

5.4

9.0

6.4

9.1

7.6

Basal ACTH (pg/mL)

16.3

9.8

12.7

8.2

5.2

17.1

CBG (µg/L)

36.6

28.3

42.4

57.4

65.0

42.2

UFC (µg/24 h)a

45.7 ± 10.0

36.3 ± 8.5

31.5 ± 9.0

50.4 ± 21.0

10.4 ± 4.8

31.2 ± 11.5

Salivary cortisol (nmol/L)

2.9

9.4

5.9

4.3

8.4

5.0

PDC 0.5 mg (µg/dL)

0.5

1.0

1.1

2.9

1.5

0.7

PDC 1 mg (µg/dL)

0.5

0.3

0.7

1.0

1.5

0.5

  1. Reference values: basal cortisol: 3.7–19.4 µg/dL; ACTH 7.2–63.3 pg/mL; CBG male: 25–55/female: 40–154 µg/L; UFC: 4.3–176 µg/24 h; nocturnal salivary cortisol < 9.7 nmol/L; and CPD < 0.8 µg/dL
  2. ACTH adrenocorticotrophic hormone, CBG cortisol binding globulin, UFC urinary free cortisol, PDC post-dexamethasone cortisol
  3. aMean ± values from three independent measurements