Table 1 Clinical characteristics of patients with a clinical diagnosis of FPL syndrome
P1 | P2 | P3 | P4 | P5 | P6 | |
|---|---|---|---|---|---|---|
Age (years) | 33 | 20 | 42 | 17 | 41 | 24 |
Sex | F | M | F | F | F | F |
Reason for medical consultation | Hirsutism | Family history | Hirsutism oligomenorrhea | Hirsutism | Cushing syndrome investigation | Family history |
Age of TA abnormality (years) | 12 | 8 | 25 | Not defined | 20 | 23 |
Acanthosis nigricans | + | + | + | + | + | + |
Clinical lipoatrophy | Four limbs, gluteal area | Lower limbs | Four limbs, gluteal area | Slight, lower limbs | Four limbs, gluteal area | Lower limbs |
Fat deposition | Face, neck | Face, neck | Face, neck, trunk | Face, neck, abdomen | Face, neck, trunk | Face, neck, trunk |
Age at T2D diagnosis (years) | Glucose intolerance | – | 36 | – | 34 | – |
Previous comorbidities | Dyslipidemia | – | HBP, dyslipidemia | – | HBP, dyslipidemia myocardial infarction (36 y) | – |
Anti-diabetic medications | No | No | Metformin, gliclazide | No | Metformin, gliclazide | No |
Other current medications | No | No | Enalapril, fibrate | No | Enalapril, HCTZ, statin, ezetimibe, fibrate | No |
Family history phenotype | Brother Nephew (P2) | Father Aunt (P1) | Niece | Grandmother Aunt | Father Daughter (P6) | Grandfather Mother (P5) |