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Fig. 3 | Diabetology & Metabolic Syndrome

Fig. 3

From: Antidiabetic efficacy of lactoferrin in type 2 diabetic pediatrics; controlling impact on PPAR-γ, SIRT-1, and TLR4 downstream signaling pathway

Fig. 3

The proposed crosstalk between surface TLRs and dysregulated metabolic factors in diabetes, by interfering with NF-κB signaling pathway, and induced proinflammatory nuclear gene overexpression; e.g.IL-1β, IL-18, and TNF-α. Moreover, the figure illustrates the targeting of lactoferrin on PPAR-γ (cytoplasmic and nuclear) and SIRT-1 (intranuclear) via a controlling impact on TLR4 downstream NF-κB signaling pathway

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