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Table 3 Association of LIPC SNPs with visceral adiposity indicators, TyG index related parameters and insulin resistance

From: LIPC variants as genetic determinants of adiposity status, visceral adiposity indicators, and triglyceride-glucose (TyG) index-related parameters mediated by serum triglyceride levels

SNPs Genotypes P* (adjusted P) P** (adjusted P)
MM Mm mm
rs2043085 CC CT TT   
LAP 2863.0 ± 2180.5 3609.6 ± 3537.8 4451.0 ± 5943.0 1.8 × 10−7 (3.2 × 10−6) 0.016 (0.288)
VAI 183.8 ± 132.6 219.0 ± 203.6 266.4 ± 381.5 2.4 × 10−7 (4.3 × 10−6) 0.011 (0.198)
TyG 8.5 ± 0.6 8.6 ± 0.7 8.8 ± 0.7 1.7 × 10−5 (3.1 × 10−4) 0.542
TyG-BMI 202.5 ± 35.0 211.7 ± 39.7 217.9 ± 38.1 2.0 × 10−5 (3.6 × 10−4) 0.026 (0.468)
TyG-WC 713.2 ± 109.5 736.9 ± 118.3 765.7 ± 117.6 1.4 × 10−6 (2.5 × 10−5) 0.013 (0.234)
HOMA-IR 2.2 ± 1.3 2.2 ± 1.4 2.3 ± 1.5 0.422 0.818
rs1532085 GG GA AA   
LAP 2876.5 ± 2181.0 3613.7 ± 3519.0 4470.7 ± 6085.4 4.5 × 10−7 (8.1 × 10−6) 0.040 (0.720)
VAI 184.1 ± 132.1 218.5 ± 202.5 270.1 ± 390.5 2.9 × 10−7 (5.2 × 10−6) 0.029 (0.522)
TyG 8.5 ± 0.6 8.6 ± 0.7 8.8 ± 0.7 1.0 × 10−5 (1.8 × 10−4) 0.701
TyG-BMI 202.8 ± 35.1 211.9 ± 39.5 217.3 ± 38.8 5.1 × 10−5 (9.2 × 10−4) 0.051 (0.918)
TyG-WC 713.4 ± 110.4 738.4 ± 117.3 763.2 ± 119.7 4.7 × 10−6 (8.5 × 10−5) 0.034 (0.612)
HOMA-IR 2.2 ± 1.3 2.2 ± 1.4 2.3 ± 1.5 0.449 0.766
rs1800588 CC CT TT   
LAP 3385.6 ± 3198.8 3746.4 ± 4593.1 3514.7 ± 3246.5 0.026 (0.468) 0.288
VAI 208.8 ± 184.7 230.6 ± 290.1 207.7 ± 176.1 0.003 (0.054) 0.163
TyG 8.6 ± 0.6 8.6 ± 0.7 8.8 ± 0.7 4.6 × 10−4 (0.008) 0.521
TyG-BMI 210.2 ± 37.4 211.9 ± 39.0 205.6 ± 39.2 0.455 0.242
TyG-WC 735.2 ± 116.2 739.7 ± 115.5 726.4 ± 125.0 0.182 0.303
HOMA-IR 2.2 ± 1.4 2.2 ± 1.4 2.2 ± 1.5 0.219 0.632
  1. Abbreviations as in Table 1
  2. MM homozygosity of major allele, Mm heterozygosity, mm homozygosity of minor allele
  3. Adjusted P: the P value were shown with Bonferroni corrections, n = 18
  4. P*: adjusted for age, sex, current smoke, hypertension medicine, HDL-C; P**: Further adjusted for TG