Table 3 Association of LIPC SNPs with visceral adiposity indicators, TyG index related parameters and insulin resistance
SNPs | Genotypes | P* (adjusted P) | P** (adjusted P) | ||
|---|---|---|---|---|---|
MM | Mm | mm | |||
rs2043085 | CC | CT | TT | Â | Â |
LAP | 2863.0 ± 2180.5 | 3609.6 ± 3537.8 | 4451.0 ± 5943.0 | 1.8 × 10−7 (3.2 × 10−6) | 0.016 (0.288) |
VAI | 183.8 ± 132.6 | 219.0 ± 203.6 | 266.4 ± 381.5 | 2.4 × 10−7 (4.3 × 10−6) | 0.011 (0.198) |
TyG | 8.5 ± 0.6 | 8.6 ± 0.7 | 8.8 ± 0.7 | 1.7 × 10−5 (3.1 × 10−4) | 0.542 |
TyG-BMI | 202.5 ± 35.0 | 211.7 ± 39.7 | 217.9 ± 38.1 | 2.0 × 10−5 (3.6 × 10−4) | 0.026 (0.468) |
TyG-WC | 713.2 ± 109.5 | 736.9 ± 118.3 | 765.7 ± 117.6 | 1.4 × 10−6 (2.5 × 10−5) | 0.013 (0.234) |
HOMA-IR | 2.2 ± 1.3 | 2.2 ± 1.4 | 2.3 ± 1.5 | 0.422 | 0.818 |
rs1532085 | GG | GA | AA | Â | Â |
LAP | 2876.5 ± 2181.0 | 3613.7 ± 3519.0 | 4470.7 ± 6085.4 | 4.5 × 10−7 (8.1 × 10−6) | 0.040 (0.720) |
VAI | 184.1 ± 132.1 | 218.5 ± 202.5 | 270.1 ± 390.5 | 2.9 × 10−7 (5.2 × 10−6) | 0.029 (0.522) |
TyG | 8.5 ± 0.6 | 8.6 ± 0.7 | 8.8 ± 0.7 | 1.0 × 10−5 (1.8 × 10−4) | 0.701 |
TyG-BMI | 202.8 ± 35.1 | 211.9 ± 39.5 | 217.3 ± 38.8 | 5.1 × 10−5 (9.2 × 10−4) | 0.051 (0.918) |
TyG-WC | 713.4 ± 110.4 | 738.4 ± 117.3 | 763.2 ± 119.7 | 4.7 × 10−6 (8.5 × 10−5) | 0.034 (0.612) |
HOMA-IR | 2.2 ± 1.3 | 2.2 ± 1.4 | 2.3 ± 1.5 | 0.449 | 0.766 |
rs1800588 | CC | CT | TT | Â | Â |
LAP | 3385.6 ± 3198.8 | 3746.4 ± 4593.1 | 3514.7 ± 3246.5 | 0.026 (0.468) | 0.288 |
VAI | 208.8 ± 184.7 | 230.6 ± 290.1 | 207.7 ± 176.1 | 0.003 (0.054) | 0.163 |
TyG | 8.6 ± 0.6 | 8.6 ± 0.7 | 8.8 ± 0.7 | 4.6 × 10−4 (0.008) | 0.521 |
TyG-BMI | 210.2 ± 37.4 | 211.9 ± 39.0 | 205.6 ± 39.2 | 0.455 | 0.242 |
TyG-WC | 735.2 ± 116.2 | 739.7 ± 115.5 | 726.4 ± 125.0 | 0.182 | 0.303 |
HOMA-IR | 2.2 ± 1.4 | 2.2 ± 1.4 | 2.2 ± 1.5 | 0.219 | 0.632 |