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Table 1 Anthropometrical examination, body fat analysis by DXA, pancreas and liver fat content by MRI-DIXON and biochemical variables in women with familial partial lipodystrophy (FPLD) and control groups

From: Pancreatic fat deposition is increased and related to beta-cell function in women with familial partial lipodystrophy

  Control (n = 8) FPLD (n = 11) p
Age (years) 32.3 (28.2–59.6) 33.0 (19.4–53.8) 0.65
BMI (kg/m2) 24.4 ± 2.8 23.3 ± 3.4 0.43
Waist (cm) 80.3 ± 4.3 81.3 ± 8.6 0.77
Hip (cm) 100.1 ± 6.9 88.2 ± 4.6 < 0.001
WHR 0.80 ± 0.04 0.92 ± 0.07 0.001
Total fat (%) 38.1 (32.8–46.2) 16.2 (13.1–27.6) < 0.01
Trunk fata (%) 38.6 (31.5–47.3) 20.9 (16.3–34.6) 0.0018
Limbs fata (%) 44.1 ± 4.4 13.2 ± 4.4 < 0.001
FMR 0.89 ± 0.06 1.85 ± 0.40 < 0.001
Pancreas fatb (%) 4.08 ± 0.64 5.26 ± 1.5 0.034
Liver fatb (log) 0.41 ± 0.18 0.77 ± 0.50 0.056
Leptin (ng/ml) 19.2 (11.5–27.4) 4.2 (2.4–29.0) 0.028
Glucose (mg/dl) 81.5 (73.0–94.0) 102.0 (76.0–168.0) 0.025
HbA1c (%) 5.05 ± 0.41 6.20 ± 0.92 0.007
AST 17.5 (12.0–28.0) 18.0 (13.0–69.0) 0.77
ALT 15.0 (9.0–29.0) 22.0 (9.0–115.0) 0.14
Total Cholesterol (mg/dl) 196.5 ± 40.3 191.5 ± 26.9 0.75
HDL-c (mg/dl) 60.8 ± 11.3 40.5 ± 6.8 < 0.001
TG (mg/dl) 116 (47–160) 203 (103–392) 0.01
Disposition index 0.24 (0.13–2.07) 0.08 (0.01–0.17) < 0.001
  1. Data are mean ± SD or median (interval)
  2. FPLD familial partial lipodystrophy, BMI body mass index, HbA1c hemoglobin A1c, WHR waist-to-hip ratio, FMR fat mass ratio (trunk/limbs fat), HDL high density lipoprotein, TG triglycerides, DI disposition index, MRI magnetic resonance imaging
  3. aBody fat estimated from dual energy X-ray absorptiometry
  4. bPancreas and liver fat measured by MRI Dixon method