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Table 1 Anthropometrical examination, body fat analysis by DXA, pancreas and liver fat content by MRI-DIXON and biochemical variables in women with familial partial lipodystrophy (FPLD) and control groups

From: Pancreatic fat deposition is increased and related to beta-cell function in women with familial partial lipodystrophy

 

Control (n = 8)

FPLD (n = 11)

p

Age (years)

32.3 (28.2–59.6)

33.0 (19.4–53.8)

0.65

BMI (kg/m2)

24.4 ± 2.8

23.3 ± 3.4

0.43

Waist (cm)

80.3 ± 4.3

81.3 ± 8.6

0.77

Hip (cm)

100.1 ± 6.9

88.2 ± 4.6

< 0.001

WHR

0.80 ± 0.04

0.92 ± 0.07

0.001

Total fat (%)

38.1 (32.8–46.2)

16.2 (13.1–27.6)

< 0.01

Trunk fata (%)

38.6 (31.5–47.3)

20.9 (16.3–34.6)

0.0018

Limbs fata (%)

44.1 ± 4.4

13.2 ± 4.4

< 0.001

FMR

0.89 ± 0.06

1.85 ± 0.40

< 0.001

Pancreas fatb (%)

4.08 ± 0.64

5.26 ± 1.5

0.034

Liver fatb (log)

0.41 ± 0.18

0.77 ± 0.50

0.056

Leptin (ng/ml)

19.2 (11.5–27.4)

4.2 (2.4–29.0)

0.028

Glucose (mg/dl)

81.5 (73.0–94.0)

102.0 (76.0–168.0)

0.025

HbA1c (%)

5.05 ± 0.41

6.20 ± 0.92

0.007

AST

17.5 (12.0–28.0)

18.0 (13.0–69.0)

0.77

ALT

15.0 (9.0–29.0)

22.0 (9.0–115.0)

0.14

Total Cholesterol (mg/dl)

196.5 ± 40.3

191.5 ± 26.9

0.75

HDL-c (mg/dl)

60.8 ± 11.3

40.5 ± 6.8

< 0.001

TG (mg/dl)

116 (47–160)

203 (103–392)

0.01

Disposition index

0.24 (0.13–2.07)

0.08 (0.01–0.17)

< 0.001

  1. Data are mean ± SD or median (interval)
  2. FPLD familial partial lipodystrophy, BMI body mass index, HbA1c hemoglobin A1c, WHR waist-to-hip ratio, FMR fat mass ratio (trunk/limbs fat), HDL high density lipoprotein, TG triglycerides, DI disposition index, MRI magnetic resonance imaging
  3. aBody fat estimated from dual energy X-ray absorptiometry
  4. bPancreas and liver fat measured by MRI Dixon method