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Table 1 Comparison of clinical characteristics, laboratory data, and NCS results between patients with type 1 and type 2 diabetes

From: Nerve conduction study of the association between glycemic variability and diabetes neuropathy

  All subjects Type 1 diabetes Type 2 diabetes p value
n 40 13 27  
Age (year) 64.1 ± 10.4 58.9 ± 14.4 66.7 ± 6.8 0.087
Disease duration (year) 16.4 ± 10.4 17.7 ± 12.6 15.7 ± 9.4 0.58
Number of patients with hypoglycemia 17 7 10 0.31
HbA1c (%) 7.8 ± 1.4 8.1 ± 2.0 7.6 ± 1.0 0.37
BMI (kg/m2) 23.5 ± 5.0 21.1 ± 3.92 24.7 ± 5.1 0.03
SBP (mmHg) 134 ± 18 131.9 ± 20.8 134.9 ± 17.4 0.64
TG (mg/dL) 146 ± 105 117.2 ± 95.1 160.1 ± 108.5 0.23
LDL (mg/dL) 103 ± 25 118.6 ± 19.9 95.9 ± 24.0 0.005
eGFR (mL/min/1.73 m2) 67.9 ± 19.9 75.0 ± 22.9 64.5 ± 17.7 0.12
UAE (mg/gCre) 10.5 [6.5–28.6] 9.6 [6.7–23.0] 11.8 [5.4–37.3] 0.65
MAGE (mg/dL) 105 ± 41.9 119.6 ± 44.4 98.0 ± 39.5 0.13
Median CMAP amp (mV) 14.4 ± 3.4 15.0 ± 4.2 14.2 ± 3.0 0.49
Median DL (m/s) 3.93 ± 0.82 3.80 ± 0.61 3.99 ± 0.92 0.50
Median MCV (m/s) 53.5 ± 3.72 53.0 ± 3.8 53.7 ± 3.7 0.56
Median F z score 2.19 ± 1.49 1.77 ± 1.54 2.39 ± 1.45 0.23
Median wrist SNAP amp (µV) 29.7 ± 13.9 33.0 ± 17.6 28.2 ± 11.8 0.31
Median SCV (m/s) 47.0 ± 10.7 48.5 ± 7.1 46.3 ± 12.1 0.54
Tibial CMAP amp (mV) 18.8 ± 7.1 20.6 ± 6.8 17.9 ± 7.3 0.26
Tibial MCV (m/s) 42.5 ± 3.71 43.5 ± 3.8 42.0 ± 3.6 0.21
Tibial F z score 2.53 ± 1.72 2.10 ± 1.32 2.73 ± 1.87 0.28
Sural SNAP amp (µV) 14.0 ± 8.6 17.0 ± 11.0 12.6 ± 7.3 0.20
Sural SCV (m/s) 46.6 ± 4.7 44.9 ± 5.3 47.4 ± 4.2 0.11
Medial plantar CNAP amp (µV) 6.14 ± 6.28 7.28 ± 7.74 5.58 ± 5.53 0.43
Medial plantar NCV (m/s) 48.4 ± 6.2 46.8 ± 5.4 49.2 ± 6.5 0.26
  1. Data: mean ± SD or median [interquartile range], unpaired t-test or Mann–Whitney U test
  2. Hypoglycemia: glucose level > 70 mg/dL for 15 min or longer
  3. HbA1c glycated hemoglobin A1c, BMI body mass index, SBP systolic blood pressure, TG triglyceride, LDL low-density lipoprotein cholesterol, eGFR estimated glomerular filtration rate, UAE urinary albumin excretion, MAGE mean amplitude of glycemic excursions, CMAP compound muscle action potential, SNAP sensory nerve action potential, CNAP compound nerve action potential, amp: amplitude, DL distal latency, MCV motor nerve conduction velocity, SCV sensory nerve conduction velocity, NCV nerve conduction velocity