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Table 4 Clinical characteristics of monkeys with USS0–1 or USS2–3

From: Characterization of spontaneously-developed non-alcoholic fatty liver disease in aged rhesus monkeys

Factor All
(n = 86)
USS 2–3
(n = 25)
USS 0–1
(n = 61)
p-value
Age (years) 18.1 ± 0.6 17.8 ± 0.5 18.2 ± 0.8 0.76
SBP (mmHg) 127.1 ± 2.3 134.3 ± 4.3 124.1 ± 2.6 0.04
DBP (mmHg) 76.4 ± 1.1 78.9 ± 1.9 75.4 ± 1.4 0.17
BW (kg) 12.8 ± 0.5 16.7 ± 1.0 11.2 ± 0.4 < 0.001
BMI 17.9 ± 0.7 23.5 ± 1.4 15.6 ± 0.5 < 0.001
WC (cm) 45.0 ± 1.5 56.6 ± 3.0 40.2 ± 1.3 < 0.001
FPG (mmol/L) 4.6 ± 0.2 5.2 ± 0.6 4.3 ± 0.1 0.03
HOMA IR 6.9 ± 1.6 14.3 ± 5.1 3.9 ± 0.5 0.003
Insulin (μU/ml) 28.0 ± 3.9 50.1 ± 11.3 19.0 ± 2.1 < 0.001
CRP (mg/dL) 0.3 ± 0.1 0.4 ± 0.1 0.3 ± 0.1 0.26
TG (mmol/L) 0.8 ± 0.1 1.3 ± 0.4 0.6 ± 0.0 0.005
TC (mmol/L) 4.1 ± 0.2 4.9 ± 0.6 3.8 ± 0.2 0.03
HDL-c (mmol/L) 1.9 ± 0.1 1.6 ± 0.1 2.0 ± 0.1 0.01
LDL-c (mmol/L) 2.0 ± 0.2 2.9 ± 0.6 1.7 ± 0.2 0.01
NEFA (mmol/L) 1.1 ± 0.1 1.4 ± 0.3 1.0 ± 0.1 0.10
ALT (U/L) 61.7 ± 4.0 65.1 ± 8.2 60.3 ± 4.5 0.59
AST (U/L) 27.4 ± 0.8 26.5 ± 1. 27.7 ± 0.9 0.52
  1. Data represented as mean ± SE; student t-test
  2. USS ultrasonographic steatosis score, SBP systolic blood pressure, DBP diastolic blood pressure, BW body weight, BMI body mass index, WC waist circumference, FPG fasting plasma glucose, HOMA IR homeostasis model assessment of insulin resistance, CRP C-reactive protein, TG triglycerides, TC total cholesterol, HDL-c high-density lipoprotein-cholesterol, LDL-c low-density lipoprotein-cholesterol, NEFA non-esterified fatty acid, ALT alanine aminotransferase, AST aspartate aminotransferase