Association between the expression of vascular endothelial growth factors and metabolic syndrome or its components: a systematic review and meta-analysis

Zafar, Mohammad Ishraq; Mills, Kerry; Ye, Xiaofeng; Blakely, Brette; Min, Jie; Kong, Wen; Zhang, Nan; Gou, Luoning; Regmi, Anita; Hu, Sheng Qing; Zheng, Juan; Chen, Lu-Lu

doi:10.1186/s13098-018-0363-0

Table 1 Characteristics of included studies

From: Association between the expression of vascular endothelial growth factors and metabolic syndrome or its components: a systematic review and meta-analysis

Study ID	Disease state	Control type	VEGF protein(s) measured	Place measured	Country	Funding	N disease group	N control	Average age	Gender	Metabolic syndrome?
Doupis 2011/1 [50]	Diabetes without obesity	Healthy	VEGF-A	Serum	USA	NIH	76	40	55	Both	No
Doupis 2011/2 [50]	Diabetes with obesity	Healthy	VEGF-A	Serum	USA	NIH	105	37	54	Both	Yes
Du 2016 [20]	Diabetes	Healthy	VEGF-A	Serum	China	Government grant	25	20	57.3	Both	No
Erman 2016 [21]	Metabolic syndrome	Healthy	VEGF-A	Serum	Turkey	No information	45	17	53.67	No info	Yes
Gomez-Ambrosi 2010 [9]	Obese	Healthy	VEGF-A, VEGF-B, VEGF-C, VEGF-D	Serum	Spain	Institutional grant	24	15	34.4	Both	No
Guo 2014 [22]	Diabetic hypertension	Healthy	VEGF-A	Serum	China	Government grant	18	26	60.5	Both	No
Hanefeld 2016 [23]	T2DM	Healthy	VEGF-A	Serum, plasma	Germany	Industry grant	302	99	67.36	Both	No
Jain 2013 [24]	T2DM	Healthy	VEGF-A	Serum	Switzerland	No information	19	19	52	Both	No
Jesmin 2013 [25]	Metabolic syndrome	Healthy	VEGF-A	Plasma	Japan	Government grant	451	1322	45.92	Female	Yes
Kakizawa 2004 [26]	Diabetes	Healthy	VEGF-A	Plasma	Japan	University grant	45	54	50.9	Both	No
Kubisz 2010 [27]	T2DM	Healthy	VEGF-A	Serum	Slovakia	University grant	42	42	61.8	Both	No
Lim 2004/1 [28]	Diabetes CVD+	Healthy	VEGF-A	Plasma	UK	No information	38	34	68	Both	Yes
Lim 2004/2 [28]	Diabetes CVD-	Healthy	VEGF-A	Plasma	UK	No information	56	34	68	Both	No
Litvinova 2014 [29]	Metabolic syndrome	Healthy	VEGF-A	Serum	Russia	Government grant	23	10	50.7	Female	Yes
Loebig 2010 [30]	Obese	Healthy	VEGF-A	Plasma	Germany	Institutional grant	15	15	27.8	Male	No
MacEneaney 2010 [31]	Obese sedentary	Healthy sedentary	VEGF-A	Supernatant	America	Government/charity grant	42	25	56	Both	No
Mahdy 2011 [32]	T2DM	Healthy	VEGF-A	Serum	Egypt	No information	10	10	58	Both	No
Marek 2010 [33]	T1DM	Healthy	VEGF-A	Serum	Poland	Government grant	60	30	16.31	Both	No
Mirhafez 2015 [34]	Metabolic syndrome	Healthy	VEGF-A	Serum	Iran	Government grant	155	148	53.91	Both	Yes
Mirhafez 2016 [35]	High triglycerides	Healthy	VEGF-A	Serum	Iran	University grant	95	260	50.5	Both	Yes
Mysliwiec 2008 [36]	T1DM	Healthy	VEGF-A	Serum	Poland	No information	163	85	12.58	Both	No
Nandy 2010 [37]	T2DM	Healthy	VEGF-A	Plasma	America	Government/university grant	8	11	55.8	Both	No
Nandy 2010/2 [37]	IGT	Healthy	VEGF-A	Plasma	America	Government/university grant	15	11	55.8	Both	No
Ozturk 2009 [38]	T2DM	Healthy	VEGF-A	Serum	Turkey	No information	31	28	63.9	Both	No
Ruszkowska-Ciastek 2014 [39]	T2DM	Healthy	VEGF-A	Serum	Poland	University grant	31	30	63.58	Both	No
Schlingemann 2013 [40]	T1DM DR- DN-	Healthy	VEGF-A	Plasma	Netherlands	No information	21	21	32	Both	No
Seckin 2006 [41]	T1DM (HbA1c > 8%)	T1DM (HbA1c ≤ 8%)	VEGF-A	Serum	Turkey	No information	70	30	9.97	Both	No
Siervo 2010 [42]	Metabolic syndrome	Healthy	VEGF-A, PIGF	Plasma	UK and Italy	Government grant	160	840	58.8	Both	Yes
Siervo 2012 [43]	Obese	Healthy	VEGF-A, PIGF	Plasma	Italy	Government grant	38	113	9.9	Both	Yes
Silha 2005 males [44]	Obese male	Healthy male	VEGF-A, VEGF-C, VEGF-D	Serum	Czech Republic, Canada	Government grant	4	24	46.3	Male	No
Silha 2005 females [44]	Obese female	Healthy female	VEGF-A, VEGF-C, VEGF-D	Serum	Czech Republic, Canada	Government grant	21	33	49.3	Female	No
Suguro 2008 [45]	T2DM	Healthy	VEGF-A	Plasma	Japan	Institutional/university grant	36	24	58	Both	Yes
Valabhji 2001 [46]	T1DM	Healthy	VEGF-A	Serum	UK	No information	41	50	39	Both	No
Wada 2010 [47]	Metabolic syndrome	Healthy	VEGF-A	Plasma	Japan	Government grant	43	229	47.2	Both	Yes
Wu 2017/1 [48]	T2DM	Healthy	VEGF-B	Plasma	China	No information	45	39	49	Both	No
Wu 2017/2 [48]	IGT	Healthy	VEGF-B	Plasma	China	No information	37	39	51	Both	No
Zorena 2010 [49]	T1DM	Healthy	VEGF-A	Serum	Poland	University grant	74	30	15	Both	No

T1DM type 1diabetes mellitus, T2DM type 2 diabetes mellitus, IGT impaired glucose tolerance, DN diabetic nephropathy, HbA1c glycated haemoglobin, CVD cardiovascular disease

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ISSN: 1758-5996

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