Fig. 6From: The metabolic syndrome modifies the mRNA expression profile of extracellular vesicles derived from porcine mesenchymal stem cellsMSC-derived EVs effects on macrophages. Co-culture with either Lean- or MetS-MSC-derived EVs similarly increased the expression of inducible nitric oxide synthase (iNOS) and decreased the expression of arginase-1 compared to M1-polarized macrophages, suggesting a switch to M2 phenotype. *p<0.05 vs. M1Back to article page