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Fig. 2 | Diabetology & Metabolic Syndrome

Fig. 2

From: The metabolic syndrome modifies the mRNA expression profile of extracellular vesicles derived from porcine mesenchymal stem cells

Fig. 2

Functional pathway analysis of mRNAs enriched in Lean- and MetS-EVs. a Lean-EVs contained genes encoding regulators of transcription, isopeptide bond, non-membrane-bounded organelle, and vesicle-mediated transport, among others. b Genes enriched in MetS-EVs were primarily involved in translation elongation and ribonucleoprotein complex. c The top six functional categories of genes enriched in Lean-EVs showed pathways related to gonadotropin-releasing hormone receptor (P06664), axon guidance mediated by netrin (P00009), apoptosis signaling (P00006), angiogenesis (P00005), Wnt signaling (P00057), and TGF-β signaling (P00052). d The top six functional categories of genes enriched pathway in MetS-EVs included integrin signaling (P00034), apoptosis signaling (P00006), inflammation mediated by chemokine and cytokine signaling (P00031), ubiquitin proteasome pathway (P00060), and FGF signaling (P00021)

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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