TCF7L2 correlation in both insulin secretion and postprandial insulin sensitivity

Table 1 Laboratory characteristics of the overall cohort (n = 162) and results of the comparative tests

Variable	rs7903146	Mean	SD	N	p
Age (years)	CC	58.42	6.15	67	0.054
Age (years)	CT/TT	56.26	7.96	95	0.054
Age/diagnosis (years)	CC	53.27	6.66	67	0.047*
Age/diagnosis (years)	CT/TT	50.88	8.47	94	0.047*
BMI (kg/m²)	CC	30.43	4.51	67	0.823
BMI (kg/m²)	CT/TT	30.61	5.44	95	0.823
Waist (cm)	CC	103.43	11.18	67	0.804
Waist (cm)	CT/TT	102.99	10.92	94	0.804
Neck (cm)	CC	38.69	3.43	67	0.053
Neck (cm)	CT/TT	37.63	3.34	93	0.053
N/T ratio	CC	0.67	0.08	67	0.008*
N/T ratio	CT/TT	0.64	0.07	93	0.008*
Blood glucose (ng/dL)	CC	146.69	59.48	61	0.988
Blood glucose (ng/dL)	CT/TT	146.84	58.63	91	0.988
HbA1c (%)	CC	7.57	1.70	61	0.943
HbA1c (%)	CT/TT	7.59	1.78	87	0.943
HDL (mg/dL)	CC	46.48	10.88	60	0.041*
HDL (mg/dL)	CT/TT	50.89	13.87	87	0.041*
Uric acid (mg/dL)	CC	5.93	1.78	53	0.017*
Uric acid (mg/dL)	CT/TT	5.23	1.40	83	0.017*
Insulin (µIU/mL)	CC	17.65	12.13	63	0.099
Insulin (µIU/mL)	CT/TT	14.55	10.80	90	0.099
C-peptide (ng/mL)	CC	3.47	1.65	63	0.015*
C-peptide (ng/mL)	CT/TT	2.87	1.36	93	0.015*

All analyses were performed with Student’s t test, with the exception of the comparison of C-peptide levels, which was assessed with the Mann–Whitney test
SD standard deviation; BMI body mass index; N/T ratio neck-to-thigh ratio; HbA1c glycosylated hemoglobin
*p < 0.05

ISSN: 1758-5996