Fig. 4

Retinal cross-sections. P2X2 immunohistochemistry in diabetic and control animals treated with purinergic receptors antagonist (PPADS). a and b Represent control groups. c and d Represent diabetic groups. b and d Groups were treated with intraperitoneal injection of PPADS. P2X2r immunostaining was seen in the photoreceptor inner segment and outer nuclear layer of controls without treatment. In the remaining animal groups immunoreactivity was found in the inner nuclear layer. GCL ganglion cells layer; INL Inner nuclear layer; PIS photoreceptor inner segment; DBT diabetic; PPADS animals treated with pyridoxalphosphate-6-azophenyl-2′,4′-disulfonic acid