From: Serum uric acid and renal function in patients with type 1 diabetes: a nationwide study in Brazil
Variables | Groups | p value | ||
---|---|---|---|---|
Normal renal function | GFR ≥60 ml/min and albuminuria | GFR < 60 ml/min | ||
n = 1686 | 1170 | 246 | 270 | |
Age, (year) | 28.7 ± 11.7 | 28.1 ± 10.0 | 37.9 ± 11.7* | p < 0.001 |
Gender, (% female) | 631 (53.9) | 125 (50.8) | 186 (68.8)* | p < 0.001 |
Duration of diabetes, (year) | 14.1 ± 9.1 | 15.2 ± 7.5 | 20.8 ± 9.8* | p < 0.001 |
Years of study, (year) | 12.3 ± 3.9 | 11.9 ± 3.5 | 11.8 ± 3.8 | p = 0.086 |
Insulin dose, (units/kg/day) | 0.86 ± 0.36 | 0.94 ± 0.46* | 0.79 ± 0.36* | p < 0.001 |
Cigarette smoking, (%) | 58 (5.0) | 15 (6.1) | 16 (5.9) | p = 0.233 |
Hypertension, (%) | 130 (11.1) | 45 (18.3)* | 119 (44)* | p < 0.001 |
Dyslipidemia, (%) | 203 (17.4) | 51 (20.8) | 105 (39)* | p < 0.001 |
Systolic blood pressure (mmhg) | 119.1 ± 14.1 | 124.2 ± 16.1* | 129.5 ± 20.7* | p < 0.001 |
Diastolic blood pressure (mmhg) | 73.3 ± 9.4 | 78.1 ± 10.6* | 79.6 ± 12.3* | p < 0.001 |
BMI (kg/m2) | 24.0 ± 4.0 | 24.1 ± 4.0 | 24.9 ± 4.3 | p = 0.005 |
HbA1c (%) | 8.9 ± 2.0 | 9.9 ± 2.5* | 8.9 ± 2.0 | p < 0.001 |
HbA1c (mmol/mol) | 73.2 ± 22.2 | 84.8 ± 27.2* | 73.5 ± 21.3 | p < 0.001 |
Serum uric acid (mg/dl) | 4.8 ± 1.4 | 5.2 ± 2.0* | 6.5 ± 2.6* | p < 0.001 |