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Table 3 Univariate and multivariate analysis of factors to predict all cause deaths at follow up

From: Effects of incretin treatment on cardiovascular outcomes in diabetic STEMI-patients with culprit obstructive and multivessel non obstructive-coronary-stenosis

 

Univariate analysis

Multivariate analysis

HR (95% CI)

p value

HR (95% CI)

p value

A. Multivariate cox regression analysis for parameters associated with all cause deaths

 Diabetes

1.603 [0.919–2.797]

0.097

2.172 [1.225–3.925]

0.010*

 Hypertension

0.658 [0.407–1.064]

0.088

1.519 [0.926–2.492]

0.098

 Dyslipidemia

0.906 [0.531–1.544]

0.716

1.232 [0.715–2.122]

0.452

 Smoke

1.784 [1.119–2.844]

0.045

1.133 [0.694–1.851]

0.621

 LVEF < 50%

1.176 [0.727–1.901]

0.51

0.901 [0.558–1.453]

0.669

 Bas.Lesion length

0.953 [0.849–1.070]

0.415

0.973 [0.866–1.092]

0.638

 Obesity

0.964 [0.529–1.758]

0.906

0.952 [0.493–1.841]

0.885

 Incretin

0.901 [0.528–1.535]

0.700

1.274 [0.664–2.447]

0.466

 VD-3

0.859 [0.493–1.497]

0.592

1.284 [0.727–2.268]

0.389

 HsCRP

1.188 [0.545–2.191]

0.665

0.623 [0.011–3.247]

0.858

 M1/M2 ratio

0.958 [0.438–2.088]

0.913

1.136 [0.319–3.221]

0.922

 LowGLP-1

0.901 [0.413–1.965]

0.793

3.714 [0.215–4.902]

0.922

B. Multivariate cox regression analysis is for parameters associated with cardiac deaths

 Diabetes

1.663 [0.951–2.908]

0.075

2.253 [1.245–4.078]

0.007*

 Hypertension

0.705 [0.433–1.146]

0.159

1.438 [0.871–2.375]

0.155

 Dyslipidemia

0.959 [0.561–1.642]

0.88

1.174 [0.679–2.031]

0.565

 Smoke

1.757 [1.092–2.828]

0.02

1.024 [0.626–1.675]

0.924

 LVEF < 50%

1.049 [0.653–1.386]

0.842

0.877 [0.538–1.430]

0.601

 Bas.Lesion length

0.942 [0.837–1.061]

0.326

0.961 [0.853–1.081]

0.638

 Obesity

1.017 [0.556–1.860]

0.956

0.859 [0.441–1.673]

0.656

 Incretin

0.816 [0.466–1.427]

0.475

1.531 [0.762–3.074]

0.231

 VD-3

0.838 [0.473–1.484]

0.544

1.285 [0.716–2.308]

0.401

 HsCRP

1.244 [0.569–2.117]

0.584

7.546 [0.716–8.403]

0.859

 M1/M2 ratio

1.003 [0.459–2.191]

0.994

1.107 [0.011–4.934]

0.991

 LowGLP-1

0.944 [0.432–2.62]

0.885

4.029 [0.028–4.802]

0.823

C. Multivariate cox regression analysis is for parameters associated with major adverse cardiac events (MACE)

 Diabetes

0.952 [0.621–1.461]

0.822

1.962 [1.124–3.422]

0.018*

 Hypertension

0.929 [0.678–1.274]

0.649

1.058 [0.751–1.490]

0.748

 Dyslipidemia

0.899 [0.634–1.275]

0.55

1.148 [0.775–1.698]

0.748

 Smoke

1.158 [0.839–1.598]

0.372

0.829 [0.578–1.190]

0.309

 LVEF < 50%

0.994 [0.725–1.363]

0.969

0.277 [0.590–1.163]

0.829

 Bas.Lesion length

1.032 [0.955-1.115]

0.048

1.023 [0.930–1.126]

0.637

 Obesity

0.320 [0.235-0.437]

0.001

1.528 [0.509-2.204]

0.064

 Incretin

0.257 [0.187–0.355]

0.001

0.565 [0.387–0.824]

0.003*

 VD-3

1.806 [1.167–2.794]

0.008

1.173 [0.728–1.888]

0.513

 HsCRP

35.947 [26.067–49.553]

0.001

1.938 [0.908–4.137]

0.087

 M1/M2 ratio

0.019 [0.014–0.027]

0.001

0.773 [0.293–2.037]

0.603

 LowGLP-1

0.018 [0.012–0.025]

0.001

1.528 [1.059–2.204]

0.024*

  1. (A) Univariate and multivariate analysis of factors to predict all cause deaths at follow up. We have considered as statistical significant a p value < 0.005, with hazard ratio (HR) at 95% of confidence of interval (CI). At multivariable analysis the parameter associated with a statistical significant value (p value < 0.005) has been marked with the symbol*. Bas.Lesion length is indicating basal lesion length; HsCRP is for high sensitivity C reactive protein; Low GLP-1 is indicating lower terzile of GLP-1 (glucagon-like peptide 1) values, as < 20 pg/ml; LVEF is for left ventricle ejection fraction; M1/M2 ratio is the ration between macrophage 1 and macrophage 2 cells. VD-3 is indicating a multivessel coronary disease with 3 coronary vessels
  2. (B) Univariate and multivariate analysis of factors to predict cardiac deaths at follow up. We have considered as statistical significant a p value < 0.005, with hazard ratio (HR) at 95% of confidence of interval (CI). At multivariable analysis is the parameter associated with a statistical significant p value (p value < 0.005) has been marked with the symbol*. Bas.Lesion length is indicating basal lesion length; HsCRP is for high sensitivity C reactive protein; Low GLP-1 (glucagon-like peptide 1) is indicating lower terzile of GLP-1values, as < 20 pg/ml; LVEF is for left ventricle ejection fraction; M1/M2 ratio is the ratio between macrophage 1 and macrophage 2 cells. VD-3 is indicating a multi vessel coronary disease with 3 coronary vessels
  3. (C) Univariate and multivariate analysis of factors to major adverse cardiac events (MACE) at follow up. We have considered as statistical significant a p value < 0.005, with hazard ratio (HR) at 95% of confidence of interval (CI). At multivariable analysis is the parameter associated with a statistical significant value (p value < 0.005) has been marked with the symbol*. Bas.Lesion length is indicating basal lesion length; HsCRP is for high sensitivity C reactive protein; Low GLP-1 (glucagon-like peptide 1) is indicating lower terzile of GLP-1 values, as < 20 pg/ml; LVEF is for left ventricle ejection fraction; M1/M2 ratio is the ratio between macrophage 1 and macrophage 2 cells. VD-3 is indicating a multivessel coronary disease with 3 coronary vessels