Table 3 Values of BMI, body weight, fasting glucose levels and HbA1c in in patients with type 2 diabetes (T2DM patients) subdivided into carriers of the COMT Val108/158Met and DBH-1021C/T genotypes

BMI (kg/m²)

29.41 (22.59–37.8)

30.02 (20.66–47.80)

30.04 (20.98–52.6)

29.28 (23.84–37.78)

30.10 (22.55–45.17)

29.39 (22.92–47.26)

Kruskal–Wallis ANOVA on Ranks

H = 0.137; df = 2; p = 0.934

H = 0.067; df = 2; p = 0.967

Body weight (kg)

85.00 (63.00–106.00)

82.00 (54.00–127.00)

84.00 (59.00–128.00)

84.00 (64.00–108.00)

83.00 (55.00–120.00)

82.00 (59.00–115.00)

Kruskal–Wallis ANOVA on ranks

H = 0.662; df = 2; p = 0.719

H = 0.167; df = 2; p = 0.920

Fasting glucose levels (mmol/L)

12.30 (7.00–18.90)

11.00 (5.20–19.70)

11.70 (8.20–21.30)

8.40 (4.40–17.70)

8.10 (4.60–15.90)

8.10 (5.40–14.50)

Kruskal–Wallis ANOVA on ranks

H = 2.116; df = 2; p = 0.347

H = 0.397; df = 2; p = 0.820

HbA1c

8.4 (7.00–11.20)

8.4 (6.20–11.80)

8.5 (7.20–12.80)

7.7 (6.20–10.20)

7.6 (5.10–10.5)

8.00 (5.80–11.90)

Kruskal–Wallis ANOVA on ranks

H = 2.684; df = 2; p = 0.261

H = 4.965; df = 2; p = 0.084

At baseline

After 52-week treatment period

DBH-1021C/T genotype (number of patients)

CC (113)

CT (64)

TT (8)

CC (113)

CT (64)

TT (8)

BMI (kg/m²)

29.88 (20.66–47.80)

30.04 (22.19–52.60)

34.26 (26.47–35.51)

30.10 (22.55–45.17)

29.40 (22.60–47.26)

30.86 (27.14–34.26)

Kruskal–Wallis ANOVA on ranks

H = 1.426; df = 2; p = 0.490

H = 1.018; df = 2; p = 0.601

Body weight (kg)

82.00 (58.00–127.00)

84.50 (54.00–128.00)

89.00 (72.00–110.00)

82.00 (57.00–120.00)

83.50 (55.00–115.00)

87.00 (72.00–106.00)

Kruskal–Wallis ANOVA on ranks

H = 1.279; df = 2; p = 0.527

H = 1.403; df = 2; p = 0.498

Fasting glucose levels

11.10 (5.20–20.10)

11.5 (7.10–21.30)

11.9 (9.10–12.80)

8.25 (5.20–15.90)

8.25 (4.40–17.70)

7.10 (6.20–11,10)

Kruskal–Wallis ANOVA on ranks

H = 1.073; df = 2; p = 0.585

H = 0.373; df = 2; p = 0.830

HbA1c

8.50 (6.50–12.80)

8.40 (6.20–11.80)

8.65 (7.80–10.20)

7.70 (5.90–11.90)

7.8 (5.10–10.30)

7.7 (6.20–8.60)

Kruskal–Wallis ANOVA on ranks

H = 0.612; df = 2; p = 0.736

H = 0.302; df = 2; p = 0.860