Association of body mass index and visceral fat with aortic valve calcification and mortality after transcatheter aortic valve replacement: the obesity paradox in severe aortic stenosis

Table 2 Univariate and multivariable median regression for the association between body fat with total AVC mass score

Body fat	Unadjusted			Age and sex-adjusted			MV-adjusted
Body fat	B	(95% CI)	p value	B	(95% CI)	p value	B	(95% CI)	p value
BMI	− 27.1	(− 47.3: − 6.59)	0.01	− 20.2	(− 40.3; − 1.17)	0.03	− 23.1	(− 44.8: − 1.26)	0.02
Overweight^a	− 76.7	(− 116.2; − 37.2)	< 0.0001	− 40.9	(− 76.3; − 5.4)	0.02	− 37.3	(− 72.8; 1.8)	0.04
Obese^a	− 77.3	(− 120.6; − 33.9)	< 0.0001	− 42.3	(− 82.4; − 2.2)	0.03	− 36.9	(− 78.0; 4.3)	0.07
Obese^b	− 0.59	(− 44.4; 43.1)	0.97	− 1.4	(− 41.1; 38.4)	0.94	0.43	(− 39.5; 40.4)	0.98
EATi	− 0.03	(− 0.9; 0.9)	0.94	− 0.6	(− 1.4; 0.2)	0.11	− 2.4	(− 7.9; 3.2)	0.39
ITFi	− 0.1	(− 0.5; 0.3)	0.58	− 0.3	(− 0.6; 0.08)	0.13	− 1.2	(− 3.4; 1.1)	0.29
VAFi	− 0.5	(− 0.9; − 0.008)	0.04	− 0.4	(− 0.9; − 0.01)	0.03	− 0.5	(− 1.0; − 0.1)	0.01
SAFi	− 0.6	(− 0.9; − 0.2)	< 0.01	− 0.3	(− 0.7; 0.2)	0.18	− 0.4	(− 0.8; 0.8)	0.11
TAFi	− 0.3	(− 0.6; − 0.1)	< 0.01	− 0.3	(− 0.5; − 0.05)	0.01	− 0.3	(− 0.49; − 0.05)	0.02

Multivariable (MV) adjustment included age, sex, body mass index, arterial hypertension, systolic blood pressure, diastolic blood pressure, diabetes mellitus dyslipidemia, and smoking status. Body mass index was not included in BMI-specific analysis
CI confidence interval, EATi epicardial adipose tissue index, ITFi intrathoracic fat volume index, SAFi subcutaneous abdominal fat index, TAFi total abdominal fat index, VAFi visceral abdominal fat index
^aNormal weight (BMI ≤ 25 kg/m²) as the reference category
^bOverweight (BMI > 25 < 30 kg/m²) as the reference category

ISSN: 1758-5996