Table 2 Comparison of metabolic parameters according to methylation profile in the MTHFR gene.
CONTROL (60) | DR (16) | DN (29) | |||||||
|---|---|---|---|---|---|---|---|---|---|
Hypermethylated | Partially methylated | p | Hypermethylated | Partially methylated | p | Hypermethylated | Partially methylated | p | |
Glycemia (mg/dl) | 147.5 ± 56.3 | 158.5 ± 62.5 | 0.9267 | 183 ± 46.8 | 126.5 ± 74.3 | 0.1172 | 155 ± 55.5 | 150 ± 50.8 | 0.5686 |
HbA1C (%) | 7.7 ± 1.3 | 7.9 ± 1.9 | 0.4615 | 8.5 ± 3 | 9.9 ± 2.4 | 0.4796 | 8.4 ± 1.8 | 7.9 ± 1.4 | 0.7924 |
Cholesterol (mg/dl) | 169 ± 42.1 | 186 ± 43.9 | 0.6900 | 207.5 ± 30.1 | 165.5 ± 20.1 | 0.0103* | 185 ± 65.3 | 199 ± 58.7 | 0.2875 |
HDL (mg/dl) | 46.5 ± 9.9 | 43 ± 11 | 0.3654 | 44.5 ± 15.6 | 40.5 ± 9.5 | 0.2869 | 44 ± 8.5 | 38.5 ± 13 | 0.3804 |
LDL (mg/dl) | 101.8 ± 39.4 | 107.9 ± 43.4 | 0.7185 | 111.5 ± 55.7 | 71.8 ± 28.7 | 0.0415* | 103.6 ± 54.5 | 126 ± 59.7 | 0.1318 |
Triglyceride (mg/dl) | 292 ± 69.5 | 159 ± 105.4 | 0.8121 | 184 ± 84.9 | 191 ± 134.7 | 0.4796 | 172 ± 169.2 | 176.5 ± 95.8 | 0.6816 |
Creatinine (mg/dl) | 0.7 ± 0.2 | 0.6 ± 0.3 | 0.8539 | 0.8 ± 0.2 | 0.9 ± 0.2 | 0.2003 | 1.1 ± 0.3 | 0.9 ± 0.3 | 0.7756 |
Urinary albumin (mg/dl) | 5.1 ± 7.7 | 5.6 ± 8.6 | 0.9449 | 11 ± 8.2 | 5.5 ± 9 | 0.3176 | 49 ± 166.2 | 45 ± 191.8 | 0.7588 |
CPR (mg/dL) | 2.4 ± 3.1 | 2.4 ± 3.4 | 0.9939 | 4.3 ± 4.5 | 4.1 ± 3.1 | 0.3605 | 3 ± 2.5 | 1.8 ± 3.5 | 0.2875 |
AGP (mg/dl) | 85.5 ± 20.3 | 76.5 ± 20 | 0.1604 | 85 ± 34.9 | 80.1 ± 36.4 | 0.3372 | 81 ± 15.4 | 63.5 ± 36.9 | 0.0080* |
TAC (%) | 57 ± 28.6 | 12.5 ± 28.1 | 0.0073* | 64.5 ± 26.3 | 33.5 ± 24.5 | 0.1349 | 36 ± 26.3 | 12 ± 18.9 | 0.0169* |
MDA (µM) | 3.8 ± 0.6 | 3.6 ± 1.1 | 0.1106 | 2.6 ± 1.1 | 2.7 ± 1.9 | 0.4582 | 3.4 ± 1.3 | 3.7 ± 1.4 | 0.3456 |