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Table 2 Comparison of metabolic parameters according to methylation profile in the MTHFR gene.

From: Hypermethylation in the promoter of the MTHFR gene is associated with diabetic complications and biochemical indicators

  CONTROL (60) DR (16) DN (29)
Hypermethylated Partially methylated p Hypermethylated Partially methylated p Hypermethylated Partially methylated p
Glycemia (mg/dl) 147.5 ± 56.3 158.5 ± 62.5 0.9267 183 ± 46.8 126.5 ± 74.3 0.1172 155 ± 55.5 150 ± 50.8 0.5686
HbA1C (%) 7.7 ± 1.3 7.9 ± 1.9 0.4615 8.5 ± 3 9.9 ± 2.4 0.4796 8.4 ± 1.8 7.9 ± 1.4 0.7924
Cholesterol (mg/dl) 169 ± 42.1 186 ± 43.9 0.6900 207.5 ± 30.1 165.5 ± 20.1 0.0103* 185 ± 65.3 199 ± 58.7 0.2875
HDL (mg/dl) 46.5 ± 9.9 43 ± 11 0.3654 44.5 ± 15.6 40.5 ± 9.5 0.2869 44 ± 8.5 38.5 ± 13 0.3804
LDL (mg/dl) 101.8 ± 39.4 107.9 ± 43.4 0.7185 111.5 ± 55.7 71.8 ± 28.7 0.0415* 103.6 ± 54.5 126 ± 59.7 0.1318
Triglyceride (mg/dl) 292 ± 69.5 159 ± 105.4 0.8121 184 ± 84.9 191 ± 134.7 0.4796 172 ± 169.2 176.5 ± 95.8 0.6816
Creatinine (mg/dl) 0.7 ± 0.2 0.6 ± 0.3 0.8539 0.8 ± 0.2 0.9 ± 0.2 0.2003 1.1 ± 0.3 0.9 ± 0.3 0.7756
Urinary albumin (mg/dl) 5.1 ± 7.7 5.6 ± 8.6 0.9449 11 ± 8.2 5.5 ± 9 0.3176 49 ± 166.2 45 ± 191.8 0.7588
CPR (mg/dL) 2.4 ± 3.1 2.4 ± 3.4 0.9939 4.3 ± 4.5 4.1 ± 3.1 0.3605 3 ± 2.5 1.8 ± 3.5 0.2875
AGP (mg/dl) 85.5 ± 20.3 76.5 ± 20 0.1604 85 ± 34.9 80.1 ± 36.4 0.3372 81 ± 15.4 63.5 ± 36.9 0.0080*
TAC (%) 57 ± 28.6 12.5 ± 28.1 0.0073* 64.5 ± 26.3 33.5 ± 24.5 0.1349 36 ± 26.3 12 ± 18.9 0.0169*
MDA (µM) 3.8 ± 0.6 3.6 ± 1.1 0.1106 2.6 ± 1.1 2.7 ± 1.9 0.4582 3.4 ± 1.3 3.7 ± 1.4 0.3456
  1. * Significant difference—t test
  2. ** Significant difference—Mann–Whitney test