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Fig. 2 | Diabetology & Metabolic Syndrome

Fig. 2

From: The impact of type 2 diabetes on bone metabolism

Fig. 2

(Adapted from Kawai et al. [43])

PPAR regulates mesenchymal cell differentiation. PPAR induces adipogenesis and suppresses osteoblastogenesis, by inhibiting Runx2 function, resulting in a reduction of osteoblasts in the bone marrow. C/EBPs CCAAT/enhancer binding proteins, Osx osterix, Runx2 runt-related transcription factor 2

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