Fig. 2
(Adapted from Kawai et al. [43])
PPAR regulates mesenchymal cell differentiation. PPAR induces adipogenesis and suppresses osteoblastogenesis, by inhibiting Runx2 function, resulting in a reduction of osteoblasts in the bone marrow. C/EBPs CCAAT/enhancer binding proteins, Osx osterix, Runx2 runt-related transcription factor 2