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Fig. 1 | Diabetology & Metabolic Syndrome

Fig. 1

From: The impact of type 2 diabetes on bone metabolism

Fig. 1

(Adapted from Sanguineti et al. [33])

The relationship between the accumulation of AGEs within the bone. Increased oxidative stress, high glycemic levels, ageing and reduced bone turnover are the main contributors to increased formation and accumulation of AGEs in bone. They induce an inflammatory process that results in activation of osteoclastogenesis, osteoblast dysfunction and accelerated development of the osteoporosis process

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