Fig. 8
From: The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors
Expression of STAT3 in diabetic mouse glomeruli. a Localization of TLR2 and STAT3 in the diabetic mouse glomeruli. In the laser-scanning confocal microscopy, the regions expressing TLR2 coincided with the regions expressing STAT3, and nuclear localization of STAT3 is observed in the nuclei of both TLR2 and STAT3-expressed cells (magnified area of the merged image, arrowheads). Bars: 20 μm. b Tissue PCR for TLR2 and STAT3 mRNA of the diabetic mouse renal cortex with Pg-LPS and eritoran administration. The mRNAs of TLR2 and STAT3 were detected in the STZ-induced type 1 diabetic ICR mice (STZ), and the expressed levels were higher in the diabetic mice with Pg-LPS (STZ-LPS). The mRNAs of STAT3 and TLR2 were not detectable in the non-diabetic mice (ICR), non-diabetic mice administered Pg-LPS (LPS), or diabetic mice administered both Pg-LPS and eritoran (eritoran)