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Fig. 4 | Diabetology & Metabolic Syndrome

Fig. 4

From: The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors

Fig. 4

Expression of TGF-β in the STZ-induced type 1 diabetic mouse glomeruli. HE staining (upper lane), immunostaining for TGF-β (green, middle lane), and merged (lower lane) immunostaining for TGF-β (green) and podoplanin (red), with DAPI staining of nuclei (blue). The TGF-β expression locates between podocytes immunostained by anti-podoplanin. Expression of TGF-β is little observed in the non-diabetic ICR mice (ICR) and non-diabetic ICR mice administered Pg-LPS (LPS), but TGF-β is observed in the STZ-induced type 1 diabetic mouse glomeruli. The expression level of TGF-β was higher in the diabetic mice administered Pg-LPS (STZ-LPS) and the level was slightly lower in the diabetic mice administered both Pg-LPS and eritoran (eritoran). Bars: 20 μm

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