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Fig. 2 | Diabetology & Metabolic Syndrome

Fig. 2

From: The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors

Fig. 2

Influence of Pg-LPS on the STZ-induced diabetic mice. The survival rate of the STZ-induced diabetic mice with Pg-LPS and the effect of the TLR4 blocker eritoran on the survival rate of the diabetic mice administered Pg-LPS were investigated. a Survival curve of the STZ-induced type 1 diabetic ICR mice with repeated administrations of Pg-LPS under the buccal mucosa. All of the nine diabetic mice administered Pg-LPS (blue curve, ICR-STZ-LPS) were euthanized within the survival period of all of the non-diabetic mice administered Pg-LPS (red curve, ICR-LPS) as did almost all of the diabetic mice not administered Pg-LPS (green curve, ICR-STZ). Diabetic mice administered both Pg-LPS and eritoran showed a slightly higher survival rate than those without eritoran administration (orange curve, ICR-STZ-LPS-eritoran). b Urinalysis of the STZ-induced type 1 diabetic ICR mice administered Pg-LPS, at the 27th week of survival. Urine reagent strips show sugar, protein and bleeding in the urine of non-diabetic ICR mice (ICR), non-diabetic ICR mice administered Pg-LPS (LPS), STZ-induced type 1 diabetic ICR mice not administered Pg-LPS (STZ), diabetic mice administered Pg-LPS (STZ-LPS), and diabetic mice administered both Pg-LPS and eritoran (eritoran). Extensive amounts of urinary sugar were observed in the diabetic mice (STZ) and the diabetic mice administered Pg-LPS (STZ-LPS), and the urinary protein content was higher in the diabetic mice administered Pg-LPS (STZ-LPS) than in the diabetic mice not administered LPS (STZ). Eritoran administration resulted in a lower urinary protein content in the surviving diabetic mice administered Pg-LPS. c Blood analysis for the STZ-induced type 1 diabetic ICR mice administered Pg-LPS. Blood from the tail vein was analyzed for blood urea nitrogen (BUN) and creatinine (CRE) at the 27th week of survival. Both BUN and CRE were significantly higher in the diabetic mice administered Pg-LPS (STZ-LPS) than in the diabetic mice not administered Pg-LPS (STZ) and other mice. There appears to be decreases in BUN and CRE in the surviving diabetic mice administered Pg-LPS and eritoran. Data are expressed as means + SD. *Significantly different in one-way ANOVA (p < 0.05)

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