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Table 3 Clinical profiles of groups according to histological classification of NAFLD by Mateonni

From: Analysis of factors influencing glucose tolerance in Japanese patients with non-alcoholic fatty liver disease

  M1 M2 M3 M4 P value
n 17 38 22 54  
Age 39.4 ± 3.1 41.3 ± 2.8 51.9 ± 3.6 50.0 ± 2.1 0.0033
Sex (M/F) 12/5 22/16 12/10 27/27 0.5159
BMI (kg/m2) 28.5 ± 1.5 29.8 ± 0.8 26.8 ± 0.9 29.4 ± 0.7 0.1418
HbA1c (%) 4.99 ± 0.10 5.39 ± 0.13 5.99 ± 0.30* 5.55 ± 0.11 0.0070
G0 (mmol/L) 5.16 ± 0.11 5.69 ± 0.15 6.12 ± 0.36 5.87 ± 0.20 0.1305
G120 (mmol/L) 8.01 ± 0.53 9.35 ± 0.59 10.80 ± 1.10 10.17 ± 0.51 0.1068
Gm (mmol/L) 8.88 ± 0.30 9.58 ± 0.38 10.68 ± 0.75 10.27 ± 0.40 0.1348
I0 (pmol/L) 48.7 ± 9.4 81.3 ± 8.5 74.4 ± 10.4 88.3 ± 8.6 0.0797
I120 (pmol/L) 568.0 ± 134.9 638.9 ± 77.9 536.4 ± 72.7 704.4 ± 65.6 0.4840
Im (pmol/L) 516.3 ± 84.5 493.9 ± 55.6 395.6 ± 49.5 561.6 ± 48.0 0.2663
IGI (pmol/mmol) 87.6 (32.9, 170.2) 67.9 (39.0, 126.3) 48.7 (35.8, 76.4) 89.4 (43.0, 130.4) 0.1965
HOMA-β 70 (51, 104) 125 (62, 169) 82 (54, 153) 109 (76, 189) 0.1645
HOMA-R 1.58 (1.10, 1.85) 3.41 (1.53, 4.11) 2.43 (1.31, 5.39) 3.045 (1.87, 5.16) 0.0049
QUICKI 0.363 ± 0.010 0.330 ± 0.005 0.333 ± 0.008 0.326 ± 0.004* 0.0014
Matsuda index 3.20 (2.69, 6.26) 2.88 (1.87, 4.97) 2.79 (1.65, 5.65) 2.65 (1.38, 3.44) 0.0845
DIO (mmol/L−1) 2.42 (1.14, 3.81) 1.10* (0.70, 1.59) 1.03* (0.39, 1.45) 1.22* (0.56, 2.08) 0.0061
OGTT
 NGT n(%) 9 (52.9) 19 (50.0) 6 (27.2) 13 (24.1) 0.0241** 0.2610***
 IGM n(%) 7 (41.2) 9 (23.7) 10 (45.5) 25 (46.3)
 DM n(%) 1 (5.9) 10 (26.3) 6 (27.2) 16 (29.6)
  1. G0, G120 and Gm are plasma glucose (PG) levels at 0 (fasting) and 120 min after glucose loading and mean PG level in 75 g OGTT, respectively. I0, I120 and Im are serum IRI levels at 0 (fasting) and 120 min after glucose loading and mean IRI level in 75 g OGTT, respectively. Gm and Im are calculated by dividing Area Under Curve of PG and IRI during OGTT by 120 min, respectively. IGI: insulinogenic index
  2. * P < 0.05 vs. M1
  3. ** NGT vs. IGM + DM among M1, M2, M3 and M4 groups; P < 0.05, M1 vs. M4; P < 0.05, M2 vs. M4
  4. *** NGT + IGM vs. DM among M1, M2, M3 and M4 groups