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Table 1 Clinical, biochemical, and pathological profiles of NGT, IGM and DM groups

From: Analysis of factors influencing glucose tolerance in Japanese patients with non-alcoholic fatty liver disease

  NGT IGM DM P value
n 47 51 33  
Age 38.9 ± 2.5 48.0 ± 2.1* 54.7 ± 2.4* <0.0001
Sex (M/F) 33/14 28/23 12/21* 0.0110
BMI (kg/m2) 29.7 ± 0.9 28.7 ± 0.7 28.4 ± 0.8 0.5028
HbA1c (%) 5.08 ± 0.08 5.24 ± 0.06 6.46 ± 0.18*,** <0.0001
G0 (mmol/L) 5.13 ± 0.09 5.54 ± 0.08 7.02 ± 0.33*,** <0.0001
G120 (mmol/L) 6.90 ± 0.24 9.08 ± 0.21* 14.86 ± 0.66*,** <0.0001
Gm (mmol/L) 7.95 ± 0.22 9.62 ± 0.17* 13.35 ± 0.48*,** <0.0001
I0 (pmol/L) 77.9 ± 7.9 74.3 ± 6.7 86.9 ± 11.9 0.6009
I120 (pmol/L) 541.8 ± 58.7 702.1 ± 68.3 681.8 ± 90.8 0.2035
Im (pmol/L) 534.1 ± 46.1 547.1 ± 53.7 411.2 ± 44.5 0.1520
IGI (pmol/mmol) 124.4 (71.5, 191.6) 75.2* (39.9, 116.6) 29.7*,** (15.8, 54.8) <0.0001
HOMA-β 144 (84, 206) 92 (62, 180) 72* (53, 115) 0.0006
HOMA-R 2.43 (1.51, 3.70) 2.41 (1.55, 4.21) 3.66 (2.05, 5.52) 0.0508
QUICKI 0.339 ± 0.005 0.336 ± 0.005 0.320 ± 0.006 0.0427
Matsuda index 2.89 (2.08, 5.20) 2.74 (1.61, 4.49) 2.31 (1.46, 3.44) 0.1561
DIO (mmol/L−1) 1.72 (1.33, 3.70) 1.15* (0.75, 1.79) 0.42*,** (0.23, 0.74) <0.0001
 M1 n(%) 9 (19.1) 7 (13.7) 1 (3.0) 0.0093***
 M2 n(%) 19 (40.4) 9 (17.7) 10 (30.3)
 M3 n(%) 6 (12.8) 10 (19.6) 6 (18.2)
 M4 n(%) 13 (27.7) 25 (49.0) 16 (48.5)
  1. G0, G120 and Gm are plasma glucose (PG) levels at 0 (fasting) and 120 min after glucose loading and mean PG level in 75 g OGTT, respectively. I0, I120 and Im are serum IRI levels at 0 (fasting) and 120 min after glucose loading and mean IRI level in 75 g OGTT, respectively. Gm and Im are calculated by dividing Area Under Curve of PG and IRI during OGTT by 120 min, respectively. IGI: insulinogenic index
  2. M1, M2, M3, and M4: type 1, 2, 3, and 4 in histological classification of NAFLD by Mateonni, respectively
  3. * P < 0.05 vs. NGT
  4. ** P < 0.05 vs. IGM
  5. *** NAFL (M1 + M2) vs. NASH (M3 + M4) among NGT, IGM, and DM groups; P < 0.05, NGT vs. IGM; P < 0.05, NGT vs. DM