Table 3 Plasma variables that significantly differ between T1DM and control subjects by univariate statistics
From: Metabolic profiling of type 1 diabetes mellitus in children and adolescents: a case–control study
VAR | Spectral range (ppm) | Assigned metabolite | Relative concentration | Increased/decreased in T1DM | p value* | %-change | |
|---|---|---|---|---|---|---|---|
T1DM | Controls | ||||||
18 | 5.4300–5.2752 | –HC=CH– in fatty acid chain | 21.95 ± 3.63 | 30.95 ± 4.00 | ↓ | 0.001 | −29.1 |
24 | 4.4100–4.3159 | C1 H and C3 H in glycerol backbone of triglycerides + OCH 2 of choline in sphingomyelin/phosphatidylcholine | 3.28 ± 1.16 | 5.09 ± 1.16 | ↓ | 0.005 | −35.6 |
34 | 4.0310–4.0136 | l-Serine | 0.70 ± 0.26 | 1.21 ± 0.22 | ↓ | 0.003 | −42.1 |
35 | 4.0136–4.0010 | l-Serine | 0.84 ± 0.28 | 1.29 ± 0.23 | ↓ | 0.008 | −34.9 |
38 | 3.9590–3.8330 | d-Glucose | 91.99 ± 16.9 | 64.44 ± 6.58 | ↑ | 0.004 | 42.8 |
41 | 3.7956–3.7820 | d-Glucose | 7.62 ± 0.60 | 6.18 ± 0.60 | ↑ | <0.001 | 23.3 |
42 | 3.7820–3.7550 | d-Glucose | 30.58 ± 5.63 | 20.56 ± 1.95 | ↑ | 0.003 | 48.7 |
43 | 3.7550–3.7390 | d-Glucose | 17.92 ± 3.83 | 11.85 ± 1.35 | ↑ | 0.005 | 51.2 |
44 | 3.7390–3.7141 | d-Glucose | 17.76 ± 3.24 | 13.05 ± 1.49 | ↑ | 0.007 | 36.1 |
51 | 3.5914–3.5649 | d-Glucose | 14.45 ± 2.19 | 10.20 ± 1.06 | ↑ | 0.002 | 41.7 |
52 | 3.5649–3.5510 | d-Glucose | 5.84 ± 1.10 | 3.65 ± 0.50 | ↑ | 0.002 | 60.0 |
54 | 3.5360–3.3980 | d-Glucose | 116.37 ± 30.40 | 69.27 ± 8.54 | ↑ | 0.005 | 68.0 |
55 | 3.3980–3.3765 | l-Tryptophan | 0.70 ± 0.32 | 1.94 ± 0.41 | ↓ | <0.001 | −63.9 |
63 | 3.1090–3.0860 | l-Cysteine | 2.28 ± 0.47 | 3.05 ± 0.39 | ↓ | 0.006 | −25.2 |
91 | 2.1230–1.9720 | –CH 2–CH=CH– in fatty acid chain | 53.13 ± 7.19 | 64.03 ± 3.76 | ↓ | 0.007 | −17.0 |
100 | 1.3450–1.2458 | CH3–(CH 2)n– in fatty acid chain | 117.69 ± 17.62 | 155.40 ± 22.01 | ↓ | 0.004 | −24.3 |
110 | 0.9660–0.8000 | CH 3–(CH2)n– in fatty acid chain | 89.10 ± 14.79 | 111.75 ± 7.83 | ↓ | 0.006 | −20.3 |