Metabolic profiling of type 1 diabetes mellitus in children and adolescents: a case–control study

Table 2 Plasma variables that significantly differ between T1DM and control subjects by multivariate statistics

VAR	Spectral range (ppm)	Assigned metabolite	Model based on all 110 VARs (including glucose related VARs)		Model based on 95 VARs (excluding glucose related VARs)
VAR	Spectral range (ppm)	Assigned metabolite	p(corr)[1]	VIP ± cvSE	p(corr)[1]	VIP ± cvSE
18	5.4300–5.2752	–HC=CH– in fatty acid chain	0.890	2.07 ± 0.71	0.787	2.77 ± 0.82
24	4.4100–4.3159	C₁ H and C₃ H in glycerol backbone of triglycerides + OCH ₂ of choline in sphingomyelin/phosphatidylcholine	0.856	0.89 ± 0.47	0.740	1.19 ± 0.63
34	4.0310–4.0136	l-Serine	0.809	0.48 ± 0.30	0.743	0.65 ± 0.40
35	4.0136–4.0010	l-Serine	0.715	0.43 ± 0.26	0.669	0.57 ± 0.38
38	3.9590–3.8330	d-Glucose	−0.837	3.56 ± 0.24
41	3.7956–3.7820	d-Glucose	−0.815	0.83 ± 0.24
42	3.7820–3.7550	d-Glucose	−0.861	2.19 ± 0.12
43	3.7550–3.7390	d-Glucose	−0.825	1.66 ± 0.14
44	3.7390–3.7141	d-Glucose	−0.782	1.42 ± 0.19
51	3.5914–3.5649	d-Glucose	−0.901	1.44 ± 0.27
52	3.5649–3.5510	d-Glucose	−0.828	1.04 ± 0.19
54	3.5360–3.3980	d-Glucose	−0.836	4.63 ± 0.54
55	3.3980–3.3765	l-Tryptophan	0.721	0.81 ± 0.28	0.870	1.08 ± 0.35
63	3.1090–3.0860	l-Cysteine	0.754	0.57 ± 0.37	0.701	0.77 ± 0.54
91	2.1230–1.9720	–CH ₂–CH=CH– in fatty acid chain	0.752	2.17 ± 0.44	0.734	2.91 ± 0.65
100	1.3450–1.2458	CH₃–(CH ₂)_n– in fatty acid chain	0.747	4.04 ± 1.52	0.728	5.41 ± 1.75
110	0.9660–0.8000	CH ₃–(CH₂)_n– in fatty acid chain	0.898	3.14 ± 0.73	0.735	4.21 ± 1.03

cvSE standard error of cross-validation, p(corr)[1] correlation scaled loading, VAR variable, VIP variable influence on projection

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