Skip to main content

Advertisement

Table 3 Allele frequencies, odds ratios and 95% confidence intervals of genetic variants and risk of T2D in DiaGene, original discovery studies and most recent meta-analysis of genome-wide-association studies

From: Introduction of the DiaGene study: clinical characteristics, pathophysiology and determinants of vascular complications of type 2 diabetes

Locus-marker Risk allele/other DiaGene Original discovery study results Morris et al. [52]
Risk allele frequency case/control/total OR (95% CI) Ceu-hap map OR (95% CI) Reference original study OR (95% CI)
CDKAL1-rs7754840 C/G 0.36/0.31/0.35 1.23 (1.061.44); P = 0.006 0.31 1.12 (1.08–1.16) [38, 39, 41, 42] 1.15 (1.11–1.19)
CENTD2-rs1552224 A/C 0.86/0.86/0.86 0.95 (0.77–1.16); P = 0.60 0.88 1.14 (1.11–1.17) [37] 1.13 (1.08–1.19)
DUSP9-rs5945326 G/A 0.22/0.22/0.22 1.02 (0.88–1.18); P = 0.77 0.12 1.27 (1.18–1.37) [37] N/A (on X-chromosome)
FTO-rs8050136 A/C 0.40/0.38/0.39 1.06 (0.91–1.22); P = 0.45 0.45 1.15 (1.09–1.22) [41] 1.11 (1.07–1.15)
HHEX-rs1111875 C/T 0.64/0.63/0.63 1.01 (0.87–1.16); P = 0.95 0.56 1.13 (1.08–1.17) [38] 1.15 (1.11–1.18)
IGFBP2-rs4402960 T/G 0.33/0.32/0.33 1.01 (0.87–1.18); P = 0.89 0.29 1.17 (1.10–1.25) [41] 1.13 (1.09–1.17)
KCNJ11-rs5219 T/C 0.37/0.39/0.37 0.92 (0.80–1.07); P = 0.29 0.50 1.15 (1.09–1.21) [38] 1.08 (1.05–1.12)
KCNQ1-rs231362 G/A 0.53/0.49/0.52 1.16 (1.001.34); P = 0.04 * 0.52 1.08 (1.06–1.10) [40] 1.11 (1.07–1.16)*
PPARG-P12A-rs1801282 C/G 0.89/0.88/0.89 1.13 (0.91–1.42); P = 0.27 0.92 1.14 (1.08–1.20) [38, 39, 42] 1.16 (1.11–1.22)
TCF7L2 rs7903146 T/C 0.36/0.28/0.34 1.37 (1.171.60); P < 0.001 0.25 1.37 (1.28–1.47) [41] 1.40 (1.35–1.46)
THADA rs7578597 T/C 0.91/0.88/0.90 1.36 (1.081.71); P = 0.01 0.92 1.15 (1.10–1.20) [41] 1.14 (1.08–1.22)
  1. Table shows odds ratios of association with type 2 diabetes for different known risk alleles tested in our study population. Logistic regression analysis is age, sex and center of inclusion-adjusted
  2. Significant odd ratios of association with type 2 diabetes are displayed in italic
  3. CEU Caucasian, OR odds-ratio, CI confidence interval
  4. * Statistically significant difference of odds ratio in association of genetic variant with T2DM when compared to Morris et al. [52]