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Table 3 Allele frequencies, odds ratios and 95% confidence intervals of genetic variants and risk of T2D in DiaGene, original discovery studies and most recent meta-analysis of genome-wide-association studies

From: Introduction of the DiaGene study: clinical characteristics, pathophysiology and determinants of vascular complications of type 2 diabetes

Locus-marker

Risk allele/other

DiaGene

Original discovery study results

Morris et al. [52]

Risk allele frequency case/control/total

OR (95% CI)

Ceu-hap map

OR (95% CI)

Reference original study

OR (95% CI)

CDKAL1-rs7754840

C/G

0.36/0.31/0.35

1.23 (1.06–1.44); P = 0.006

0.31

1.12 (1.08–1.16)

[38, 39, 41, 42]

1.15 (1.11–1.19)

CENTD2-rs1552224

A/C

0.86/0.86/0.86

0.95 (0.77–1.16); P = 0.60

0.88

1.14 (1.11–1.17)

[37]

1.13 (1.08–1.19)

DUSP9-rs5945326

G/A

0.22/0.22/0.22

1.02 (0.88–1.18); P = 0.77

0.12

1.27 (1.18–1.37)

[37]

N/A (on X-chromosome)

FTO-rs8050136

A/C

0.40/0.38/0.39

1.06 (0.91–1.22); P = 0.45

0.45

1.15 (1.09–1.22)

[41]

1.11 (1.07–1.15)

HHEX-rs1111875

C/T

0.64/0.63/0.63

1.01 (0.87–1.16); P = 0.95

0.56

1.13 (1.08–1.17)

[38]

1.15 (1.11–1.18)

IGFBP2-rs4402960

T/G

0.33/0.32/0.33

1.01 (0.87–1.18); P = 0.89

0.29

1.17 (1.10–1.25)

[41]

1.13 (1.09–1.17)

KCNJ11-rs5219

T/C

0.37/0.39/0.37

0.92 (0.80–1.07); P = 0.29

0.50

1.15 (1.09–1.21)

[38]

1.08 (1.05–1.12)

KCNQ1-rs231362

G/A

0.53/0.49/0.52

1.16 (1.00–1.34); P = 0.04 *

0.52

1.08 (1.06–1.10)

[40]

1.11 (1.07–1.16)*

PPARG-P12A-rs1801282

C/G

0.89/0.88/0.89

1.13 (0.91–1.42); P = 0.27

0.92

1.14 (1.08–1.20)

[38, 39, 42]

1.16 (1.11–1.22)

TCF7L2 rs7903146

T/C

0.36/0.28/0.34

1.37 (1.17–1.60); P < 0.001

0.25

1.37 (1.28–1.47)

[41]

1.40 (1.35–1.46)

THADA rs7578597

T/C

0.91/0.88/0.90

1.36 (1.08–1.71); P = 0.01

0.92

1.15 (1.10–1.20)

[41]

1.14 (1.08–1.22)

  1. Table shows odds ratios of association with type 2 diabetes for different known risk alleles tested in our study population. Logistic regression analysis is age, sex and center of inclusion-adjusted
  2. Significant odd ratios of association with type 2 diabetes are displayed in italic
  3. CEU Caucasian, OR odds-ratio, CI confidence interval
  4. * Statistically significant difference of odds ratio in association of genetic variant with T2DM when compared to Morris et al. [52]