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Table 3 Association of FTO SNPs with anthropometric characteristics, adipokines, ghrelin and TNF-α in GDM patients

From: Gene variants in the FTO gene are associated with adiponectin and TNF-alpha levels in gestational diabetes mellitus

FTO rs8050136/ rs9939609

CC/ TT

CA and AA/ TA and AA

P value

P corr

Pre-pregnancy weight (kg)

72 (60–79)

70.5 (63.5–79.6)

0.729

0.804

Pre-pregnancy BMI (kg/m2)

30 (26.9–33.2)

29.8 (26.3–32.1)

0.805

0.901

Gestational weight gain (kg)

6.3 (2.8–10.0)

8.5 (3.6–12.5)

0.283

0.352

Fasting glucose (mg/dL)

101.5 (88.7–123.6)

90.4 (76.1–119.5)

0.313

0.319

Insulin (μIU/mL)

19.2 (7.5–32.8)

17.3 (4.4–35.8)

0.951

0.986

HOMA-IR

4.1 (1.9–10.2)

4.0 (4.0–10.9)

0.671

0.772

Leptin (ng/mL)

19.9 (15.8–26.9)

15.5 (13.4–23.1)

0.211

0.169

Adiponectin (ng/mL)

10.1 (7.3–11.2)

5.5 (3.8–7.8)

0.043

0.048

Ghrelin (pg/mL)

626.1 (487.7–728.8)

618.7 (505.9–690.3)

0.864

0.654

TNF-alpha (pg/mL)

10.0 (9.0–11.9)

12.8 (10.1–13.2)

0.040

0.043

FTO rs1421085

TT

TC and CC

  

Pre-pregnancy weight (kg)

74 (63.5–80)

70.0 (62.5–82.9)

0.894

0.902

Pre-pregnancy BMI (kg/m2)

30.7 (27.0–34.0)

28.6 (25.8–32.2)

0.583

0.632

Gestational weight gain (kg)

6.0 (2.0–10.0)

9.0 (5.5–13.5)

0.004

0.012

Fasting glucose (mg/dL)

100.2 (87.9–123.5)

90.9 (75.6–119.9)

0.651

0.775

Insulin (μIU/mL)

19.5 (7.9–36.8)

16.6 (4.2–40.6)

0.846

0.942

HOMA-IR

5.2 (2.1–11.5)

4.0 (0.86–11.7)

0.898

0.875

Leptin (ng/mL)

20.6 (16.5–24.5)

14.7 (13.3–22.4)

0.462

0.563

Adiponectin (ng/mL)

9.7 (6.8–11.2)

6.6 (4.3–9.0)

0.101

0.223

Ghrelin (pg/mL)

626.1 (489.9–735.4)

574.0 (494.2–638.6)

0.419

0.532

TNF-alpha (pg/mL)

9.8 (9.0–11.7)

12.0 (10.0–13.0)

0.048

0.05

  1. Data are expressed as median (interquartile range 25–75%)
  2. SNPs single nucleotide polymorphisms, GDM gestational diabetes mellitus, FTO fat mass and obesity associated gene, BMI body mass index, HOMA-IR homeostasis model assessment index
  3. P corr, adjusted for age and pre-gestational body weight