Urinary podocyte-associated mRNA levels correlate with proximal tubule dysfunction in early diabetic nephropathy of type 2 diabetes mellitus

Petrica, Ligia; Ursoniu, Sorin; Gadalean, Florica; Vlad, Adrian; Gluhovschi, Gheorghe; Dumitrascu, Victor; Vlad, Daliborca; Gluhovschi, Cristina; Velciov, Silvia; Bob, Flaviu; Matusz, Petru; Milas, Oana; Secara, Alina; Simulescu, Anca; Popescu, Roxana

doi:10.1186/s13098-017-0228-y

Table 4 Multivariable regression analysis for urinary mRNA of podocyte-associated molecules

From: Urinary podocyte-associated mRNA levels correlate with proximal tubule dysfunction in early diabetic nephropathy of type 2 diabetes mellitus

Parameter	Variable	Coef β	p	95% CI	Prob > F	R²
NPHS1	Constant	0.065	0.083	−0.008 to 0.140	<0.0001	0.808
	Podocytes	0.021	<0.0001	0.015 to 0.027
	UACR	0.0001	<0.0001	0.00006 to 0.0001
	KIM-1/creat	0.0002	0.04	0.00001 to 0.0004
	eGFR	−0.0018	0.061	−0.0007 to −0.005
	Nephrin/creat	0.0004	0.007	0.0002 to 0.001
NPHS2	Constant	0.029	0.449	−0.047 to 0.106	<0.0001	0.825
	Podocytes	0.022	<0.0001	0.015 to 0.028
	UACR	0.0001	<0.0001	0.00005 to 0.0001
	KIM-1/creat	0.0002	0.013	0.00061 to 0.0005
	eGFR	−0.0009	0.004	−0.0015 to −0.0003
	Nephrin/creat	0.0218	0.002	0.0341 to 0.5164
Alpha actinin-4	Constant	0.2411	0.085	−0.0341 to 0.5164	<0.0001	0.805
	Podocytes	0.027	<0.0001	0.019 to 0.034
	UACR	0.00009	0.01	0.00002 to 0.0001
	eGFR	−0.002	0.042	−0.0033 to −0.00007
CD2AP	Constant	0.466	<0.0001	0.320 to 0.613	<0.0001	0.663
	Podocytes	0.018	<0.0001	0.009 to 0.028
	UACR	0.00008	0.04	4.00e−06 to 0.0001
	eGFR	−0.001	0.023	−0.0033 to −0.0002
	KIM-1/creat	0.0008	0.007	0.0002 to 0.0014
	VEGF	0.0004	0.005	0.0001 to 0.0007
ADAM10	Constant	0.055	0.265	−0.042 to 0.154	<0.0001	0.726
	Podocytes	0.025	<0.0001	0.017 to 0.033
	UACR	0.00008	0.032	7.57e-06 to 0.0001
	eGFR	−0.002	0.016	−0.0026 to −0.0004
	Alpha-1 microglobulin	0.0074	<0.0001	0.0044 to 0.0105
GLEPP-1	Constant	0.435	<0.0001	0.287 to 0.583	<0.0001	0.720
	Podocytes	0.02	<0.0001	0.01 to 0.029
	UACR	0.0009	0.019	0.00001 to 0.0001
	VEGF	0.0004	0.009	0.0001 to 0.0006
	KIM-1/creat	0.0008	0.009	0.0002 to 0.001
	eGFR	−0.002	0.013	−0.003 to −0.0004
NFkB	Constant	0.445	<0.0001	0.294 to 0.595	<0.0001	0.724
	Podocytes	0.02	<0.0001	0.01 to 0.029
	UACR	0.0001	0.011	0.00002 to 0.0001
	VEGF	0.0003	0.010	0.00009 to 0.0007
	KIM-1/creat	0.0007	0.019	0.0001 to 0.0014
	eGFR	−0.0019	0.018	−0.003 to −0.0003

UACR: urinary albumin:creatinine ratio; Alpha1/creat: urinary alpha₁-microglobulin:creatinine ratio; KIM-1/creat: urinary kidney injury molecule-1:creatinine ratio; VEGF/creat: urinary vascular endothelial growth factor:creatinine ratio; Nephrin/creat: urinary nephrin:creatinine ratio; eGFR: estimated glomerular filtration rate; AGE advanced glycation end-products; NPHS1-nephrin, NPHS2-podocin, CD2AP-CD2-associated protein, GLEPP 1-glomerular epithelial protein 1, NFκB-nuclear factor κB

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ISSN: 1758-5996

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