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Table 3 Univariable regression analysis for urinary mRNA of podocyte-associated molecules

From: Urinary podocyte-associated mRNA levels correlate with proximal tubule dysfunction in early diabetic nephropathy of type 2 diabetes mellitus

Parameter

Variable

R2

Coef β

p

NPHS1-nephrin

Podocytes

0.546

0.037

<0.0001

UACR

0.603

0.0003

<0.0001

Nephrin/creat

0.404

0.040

<0.0001

VEGF/creat

0.380

0.0003

<0.0001

Alpha1/creat

0.418

0.006

<0.0001

KIM-1/creat

0.482

0.0004

<0.0001

eGFR

0.575

−0.005

<0.0001

CystatinC

0.521

0.269

<0.0001

Urinary AGE

0.435

0.0004

<0.0001

NPHS2-podocin

Podocytes

0.546

0.041

<0.0001

UACR

0.591

0.0003

<0.0001

Nephrin/creat

0.472

0.047

<0.0001

VEGF/creat

0.457

0.0003

<0.0001

Alpha1/creat

0.492

0.007

<0.0001

KIM-1/creat

0.553

0.0005

<0.0001

eGFR

0.607

−0.005

<0.0001

CystatinC

0.579

0.308

<0.0001

Urinary AGE

0.500

0.0005

<0.0001

Alpha actinin-4

Podocytes

0.538

0.045

<0.0001

UACR

0.540

0.0003

<0.0001

Nephrin/creat

0.399

0.048

<0.0001

VEGF/creat

0.383

0.0003

<0.0001

Alpha1/creat

0.403

0.007

<0.0001

KIM-1/creat

0.465

0.0005

<0.0001

eGFR

0.616

−0.006

<0.0001

CystatinC

0.539

0.330

<0.0001

Urinary AGE

0.427

0.0005

<0.0001

CD2-AP

Podocytes

0.423

0.032

<0.0001

UACR

0.434

0.0002

<0.0001

Nephrin/creat

0.317

0.034

<0.0001

VEGF/creat

0.317

0.0002

<0.0001

Alpha1/creat

0.324

0.005

<0.0001

KIM-1/creat

0.378

0.0004

<0.0001

eGFR

0.474

−0.004

<0.0001

CystatinC

0.432

0.236

<0.0001

Urinary AGE

0.333

0.0003

<0.0001

ADAM10

Podocytes

0.494

0.040

<0.0001

UACR

0.491

0.0003

<0.0001

Nephrin/creat

0.378

0.043

<0.0001

VEGF/creat

0.366

0.0003

<0.0001

Alpha1/creat

0.388

0.006

<0.0001

KIM-1/creat

0.446

0.0005

<0.0001

eGFR

0.557

−0.005

<0.0001

CystatinC

0.500

0.293

<0.0001

Urinary AGE

0.400

0.0004

<0.0001

GLEPP-1

Podocytes

0.455

0.037

<0.0001

UACR

0.484

0.003

<0.0001

Nephrin/creat

0.387

0.042

<0.0001

VEGF/creat

0.391

0.0003

<0.0001

Alpha1/creat

0.409

0.006

<0.0001

KIM-1/creat

0.463

0.0005

<0.0001

eGFR

0.534

−0.005

<0.0001

CystatinC

0.499

0.282

<0.0001

Urinary AGE

0.414

0.0004

<0.0001

NfKB

Podocytes

0.456

0.037

<0.0001

UACR

0.496

0.0003

<0.0001

Nephrin/creat

0.400

0.043

<0.0001

VEGF/creat

0.405

0.0003

<0.0001

Alpha1/creat

0.423

0.007

<0.0001

KIM-1/creat

0.577

0.0005

<0.0001

eGFR

0.536

−0.005

<0.0001

CystatinC

0.507

0.291

<0.0001

Urinary AGE

0.426

0.0004

<0.0001

  1. UACR: urinary albumin:creatinine ratio; Alpha1/creat: urinary alpha1-microglobulin:creatinine ratio; KIM-1/creat: urinary kidney injury molecule-1:creatinine ratio; VEGF/creat: urinary vascular endothelial growth factor:creatinine ratio; Nephrin/creat: urinary nephrin:creatinine ratio; eGFR: estimated glomerular filtration rate; AGE: advanced glycation end-products; NPHS1-nephrin, NPHS2-podocin, CD2AP-CD2-associated protein, GLEPP 1-glomerular epithelial protein 1, NFkB-nuclear factor κB