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Table 5 Comparison of characteristics and complications between the young- and old-onset T2DM cohorts at last contact

From: Characteristics and cardiovascular complications of a large cohort of adults diagnosed with type 2 diabetes <45 years

 

Age at diagnosis <45 years

N = 886

Age at diagnosis 60–70 years

N = 933

p value

Adjusted p value

% Men

55.9

53.2

0.246

 

% Belgian nationality

91.3

97.2

0.024

 

Mean age at last visit (years)

57.3 ± 12.6

75.7 ± 6.8

<0.0001

 

Median age at diagnosis (years)

39.0 (8;45)

64.1 (60;70)

<0.0001

 

Median follow-up (years)

7.6 (0;17)

4.6 (1;17)

<0.0001

 

Mean diabetes duration (years)

20.5 ± 11.8

11.9 ± 6.6

<0.0001

 

Mean HbA1c % (mmol/mol)

7.3 ± 1.3 (56 ± 14)

6.9 ± 1.0 (51 ± 11)

<0.0001

 

Mean BMI (kg/m2)

31.2 ± 5.8

29.6 ± 5.5

<0.0001

 

 % Overweight

32.4

38.3

0.011

 

 % Obese

56.8

42.0

<0.0001

 

 % Hypertension

49.9

50.2

0.905

 

Median TG

118.5 (25;2837)

118.0 (24;706)

0.829

 

Mean LDL

77.5 ± 30.9

75.2 ± 29.4

0.163

 

 % Smoking

16.6

7.0

<0.0001

 

 % DRP

40.2

23.7

<0.0001

 

 % Microalbuminuria

34.4

34.0

0.915

 

 % Carotid surgery

0.9 (8)

4.3 (40)

<0.0001

0.843

 % Surgery lower limbs

6.9 (61)

10.5 (98)

0.006

0.327

 % TIA/CVA

7.2 (64)

16.1 (150)

<0.0001

0.739

 % Cardiac event

20.1 (178)

31.8 (297)

<0.0001

0.386

  1. Data are mean ± SD or %
  2. p values highlighted in italic are considered significant
  3. BMI body mass index; TG triglycerides; LDL LDL-cholesterol; DRP diabetic retinopathy; TIA transient ischemic attack; CVA cerebrovascular accident; cardiac event a myocardial infarction or an intervention such as a percutaneous transluminal coronary angioplasty or a coronary artery bypass graft