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Table 2 Clinical characteristics of subjects with NGT according to family history of diabetes in first-degree relatives

From: Increased risk of metabolic disorders in healthy young adults with family history of diabetes: from the Korea National Health and Nutrition Survey

 

Total (n = 1704)

Men (n = 691)

Women (n = 1053)

FH−

FH+

P

P a

P b

FH−

FH+

P

P a

P b

FH−

FH+

P

P a

P b

(n = 1358)

(n = 346)

(n = 533)

(n = 158)

(n = 825)

(n = 228)

Age (years)

34.8 ± 5.4

35.7 ± 5.2

0.004

  

35.1 ± 5.5

35.5 ± 5.5

0.439

  

34.7 ± 5.3

35.9 ± 5.0

0.002

  

Height (cm)

165.0 ± 8.4

165.5 ± 8.3

0.320

0.200

0.320

172.9 ± 5.7

173.0 ± 5.5

0.887

0.767

0.766

160.0 ± 5.4

160.4 ± 5.5

0.301

0.113

0.107

Weight (cm)

62.2 ± 11.9

63.8 ± 12.2

0.023

0.027

0.286

71.5 ± 10.4

73.6 ± 10.8

0.025

0.020

0.845

56.3 ± 8.7

57.0 ± 7.7

0.242

0.832

0.108

BMI (kg/m2)

22.7 ± 3.3

23.2 ± 3.3

0.023

0.046

 

23.9 ± 3.1

24.6 ± 3.4

0.018

0.012

 

22.0 ± 3.2

22.2 ± 2.8

0.443

0.853

 

WC (cm)

77.1 ± 9.6

78.1 ± 9.3

0.058

0.108

0.944

82.4 ± 8.6

84.0 ± 8.5

0.035

0.039

0.806

73.6 ± 8.6

74.0 ± 7.6

0.492

0.774

0.778

SBP (mmHg)

107.9 ± 12.5

109.2 ± 12.4

0.062

0.126

0.331

113.0 ± 12.1

114.8 ± 11.5

0.085

0.096

0.291

104.6 ± 11.7

105.4 ± 11.5

0.380

0.766

0.776

DBP (mmHg)

71.4 ± 10.1

72.8 ± 10.0

0.019

0.045

0.153

75.8 ± 10.2

78.0 ± 10.0

0.017

0.021

0.095

68.6 ± 9.0

69.2 ± 8.4

0.359

0.713

0.724

TC (mg/dL)

179.9 ± 33.4

184.9 ± 32.4

0.009

0.024

0.086

186.4 ± 34.4

195.3 ± 35.9

0.006

0.007

0.034

175.9 ± 32.1

177.5 ± 27.8

0.476

0.641

0.667

TG (mg/dL)c

89.0 (62.0–134.0)

100.5 (65.0–162.8)

<0.001

<0.001

0.002

112.0 (77.5–165.0)

137.0 (92.8–203.0)

<0.001

<0.001

0.006

72.0 (53.5–104.0)

78.0 (55.0–109.8)

0.020

0.022

0.019

HDL (mg/dL)c

48.7 (41.7–56.5)

46.9 (40.8–56.5)

0.085

0.147

0.367

45.2 (40.0–52.2)

43.4 (38.2–49.8)

0.064

0.070

0.277

52.2 (45.2–60.0)

52.6 (44.3–59.1)

0.524

0.823

0.835

LDL (mg/dL)

108.6 ± 29.1

110.9 ± 26.9

0.164

0.314

0.576

113.3 ± 30.6

117.8 ± 29.0

0.113

0.136

0.313

105.7 ± 27.7

106.3 ± 24.5

0.779

0.887

0.871

AST (IU/L)c

18.0 (15.0–21.0)

18.0 (16.0–22.0)

0.467

0.604

0.993

20.0 (18.0–24.5)

22.0 (18.0–26.0)

0.205

0.211

0.556

16.0 (15.0–19.0)

16.0 (15.0–18.0)

0.476

0.276

0.270

ALT (IU/L)c

14.0 (11.0–22.0)

15.0 (11.0–23.0)

0.076

0.108

0.338

21.0 (15.0–31.0)

24.0 (17.8–32.3)

0.037

0.037

0.244

12.0 (10.0–15.0)

12.0 (10.0–15.8)

0.715

0.974

0.991

GGT (IU/L)c

17.0 (12.0–27.5)

18.0 (13.0–30.0)

0.033

0.062

0.171

29.0 (19.0–48.0)

30.0 (22.0–53.0)

0.107

0.132

0.460

13.0 (11.0–17.0)

14.0 (12.0–18.0)

0.110

0.137

0.138

FPG (mg/dL)

87.8 ± 5.9

89.0 ± 5.5

<0.001

0.003

0.006

89.1 ± 5.8

90.0 ± 5.2

0.094

0.115

0.327

87.0 ± 5.8

88.3 ± 5.4

0.002

0.009

0.008

Insulin (μIU/mL)c

9.25 (7.61–11.40)

9.27 (7.69–11.78)

0.830

0.720

0.667

9.32 (7.56–11.45)

9.76 (7.89–12.42)

0.115

0.104

0.602

8.72 (7.58–11.53)

9.16 (7.63–11.36)

0.272

0.335

0.265

HOMA-IRc

2.00 (1.63–2.53)

2.05 (1.66–2.64)

0.391

0.367

0.877

2.06 (1.65–2.58)

2.24 (1.77–2.68)

0.074

0.071

0.486

1.92 (1.59–2.48)

1.96 (1.61–2.47)

0.668

0.685

0.606

HOMA-βc

137.5 (111.1–174.6)

134.2 (105.0–164.9)

0.020

0.047

0.018

130.8 (105.6–165.4)

135.50 (103.68–170.87)

0.745

0.655

0.787

140. 7 (114.1–179.0)

132.6 (105.2–163.8)

0.001

0.006

0.004

  1. Subjects with normal glucose tolerance are included in this analysis (n = 1704). Data are presented as mean ± standard deviation (for normal distribution) or as median (interquartile range)
  2. Statistical significance was defined as a P value of <0.05 (Italic values)
  3. FH family history of diabetes, WC waist circumference, SBP systolic blood pressure, DBP diastolic blood pressure, TC total cholesterol, TG triglycerides, FPG fasting plasma glucose, HOMA-IR and HOMA-B homeostatic model assessment of insulin resistance and beta cell
  4. P values are calculated by t test
  5. aP values adjusted for age
  6. bP values adjusted for age and BMI
  7. cThese variables were log transformed for the analysis
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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