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Table 1 Characteristic of subjects

From: C-peptide is independent associated with diabetic peripheral neuropathy: a community-based study

  Non-DPN (128) P 1V3 Clinically-DPN (35) P 1V2 Comfirmed DPN (57) P 2V3
Age (year) 62.3 ± 8.4 0.449 63.3 ± 10.7 0.527 64.5 ± 8.8 0.726
Sex (male %) 41% 0.568 58.40% 0.634 46% 0.62
Diabetes duration (year) 8.5 ± 7.2 0.084 9.7 ± 7.7 0.435 12.6 ± 6.9 0.228
Smoking 12 (9.4%) 0.736 4 (11.4%) 0.543 6 (10.5) % 0.612
BMI (kg/cm2) 25.1 ± 3.8 0.393 25.8 ± 4.7 0.421 26.9 ± 1.3 0.167
SBP (mmHg) 133 ± 16 0.036 135 ± 16 0.501 141 ± 13 0.056
DBP (mmHg) 78 ± 8 0.239 77 ± 11 0.431 83 ± 9 0.068
FPG (mmol/L) 8.40 ± 2.43 0.033 8.89 ± 2.33 0.523 9.37 ± 2.60 0.465
2 h-PG (mmol/L) 15.79 ± 4.81 0.012 16.47 ± 4.63 0.607 18.14 ± 4.81 0.263
TC (mmol/L) 5.30 ± 1.02 0.356 5.19 ± 1.06 0.737 5.10 ± 1.26 0.823
TG (mmol/L) 2.11 ± 1.17 0.742 2.38 ± 0.82 0.448 2.05 ± 1.12 0.383
HDL-C (mmol/L) 1.33 ± 0.45 0.018 1.18 ± 0.18 0.217 1.14 ± 0.22 0.788
LDL-C (mmol/L) 2.96 ± 0.77 0.906 3.02 ± 0.83 0.804 2.98 ± 1.09 0.878
HBA1c (%) 7.4 ± 1.4 0.007 7.6 ± 1.4 0.929 8.5 ± 1.9 0.229
GA (%) 18.7 ± 3.7 0.091 20.4 ± 5.2 0.417 22.8 ± 6.1 0.086
Cr (μmol/L) 61.54 ± 15.35 0.276 63.94 ± 17.11 0.63 67.6 ± 17.30 0.278
eGFR (mL/min/1.73 m2) 104.35 ± 31.32 0.857 106.34 ± 26.13 0.826 105.45 ± 30.86 0.93
Median MNCV 53.7 ± 3.1 <0.001 51.2 ± 5.7 0.033 46.5 ± 3.4 0.005
Median MNCA 8.9 ± 2.3 0.014 7.8 ± 2.8 0.398 6.9 ± 2.4 0.516
Median SNCV 51.8 ± 8.6 0.001 48.7 ± 8.8 0.086 41.9 ± 8.3 0.028
Median SNCA 21.4 ± 6.8 <0.001 17.0 ± 8.2 0.03 9.6 ± 5.4 <0.001
Tibial MNCV 44.5 ± 3.2 0.012 40.8 ± 5.89 0.007 35.8 ± 6.0 0.15
Tibial MNCA 8.7 ± 3.1 <0.001 8.2 ± 3.7 0.649 5.2 ± 3.5 0.02
Sural SNCV 50.3 ± 8.5 <0.001 47.5 ± 6.3 0.114 36.3 ± 3.9 0.002
Sural SNCA 13.2 ± 5.6 <0.001 10.4 ± 3.2 0.114 6.1 ± 3.1 <0.001
Insulin 16 (12.5%) 0.347 7 (20%) 0.576 13 (22.4%) 0.747
Sulfonylureas 32 (25.0%) 0.415 10 (28.6%) 0.589 21 (36.8%) 0.467
Metformin 46 (35.9%) 0.423 14 (40%) 0.71 25 (43.8%) 0.745
ACEI or ARB 33 (25.8%) 0.768 12 (34.3%) 0.896 19 (33.3%) 0.824
  1. Results expressed as mean (standard deviation) or percentage
  2. DPN diabetic peripheral neuropathy, BMI body mass index, DBP diastolic blood pressure, SBP systolic blood pressure, FPG fasting plasma glucose, 2 h-PG 2 h-postprandial glucose, TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, HbA1c glycosylated hemoglobin A1c, GA glycated albumin, Cr serum creatinine, eGFR estimated glomerular filtration rate, MNCV motor nerve conduction velocity, MNCA motor nerve conduction amplitude, SNCV sensory nerve conduction velocity, SNCA sensory nerve conduction amplitude, ACEI angiotensin-converting enzyme inhibitors, ARB, angiotensin receptor blocker, P 1V3 non-DPN versus confirmed DPN, P 1V2 non-DPN versus clinical DPN, P 2V3 clinical DPN versus confirmed DPN