Table 3 Genotype and allele frequencies of four SNPs between T2DM case and control group
SNPs | Genotypes and Alleles | Frequencies N(%) | OR (95% CI)a | p values | HWE test | |
|---|---|---|---|---|---|---|
Case (n = 647) | Control (n = 650) | |||||
rs3856806 | CC | 322 (49.8) | 397 (61.1) | 1.00 | <0.001 | 0.379 |
CT | 256 (39.6) | 217 (33.4) | 1.12 (1.06–1.58) | |||
TT | 69 (10.7) | 36 (5.5) | 1.93 (1.34–2.71) | |||
CT + TT | 325 (50.2) | 253 (38.9) | 1.25 (1.17–1.76) | <0.001 | ||
C | 900 (69.6) | 1011 (77.8) | <0.001 | |||
T | 394 (30.4) | 289 (22.2) | ||||
rs709158 | AA | 341 (52.7) | 373 (57.4) | 1.00 | 0.128 | 0.165 |
AG | 243 (37.6) | 230 (35.4) | 1.06 (0.95–1.37) | |||
GG | 63 (9.7) | 47 (7.2) | 1.10 (0.86–1.61) | |||
AG + GG | 306 (47.3) | 277 (42.6) | 1.07 (0.92–1.43) | 0.090 | ||
A | 925 (71.5) | 976 (75.1) | 0.039 | |||
G | 369 (28.5) | 324 (24.9) | ||||
rs1805192 | CC | 330 (51.0) | 406 (62.5) | 1.00 | <0.001 | 0.385 |
CG | 262 (40.5) | 220 (33.8) | 1.42 (1.61–1.84) | |||
GG | 55 (8.5) | 24 (3.7) | 2.13 (1.72–2.93) | |||
CG + GG | 317 (49.0) | 244 (37.5) | 1.76 (1.45–2.06) | <0.001 | ||
C | 922 (71.2) | 1032 (79.4) | <0.001 | |||
G | 372 (28.8) | 268 (20.6) | ||||
rs4684847 | CC | 346 (53.5) | 379 (58.3) | 1.00 | 0.203 | 0.277 |
CT | 250 (38.6) | 228 (35.1) | 1.08 (0.91–1.36) | |||
TT | 51 (7.9) | 43 (6.6) | 1.04 (0.82–1.53) | |||
CT + TT | 301 (46.5) | 271 (41.7) | 1.07 (0.89–1.39) | 0.080 | ||
C | 942 (72.8) | 986 (75.8) | 0.076 | |||
T | 352 (27.2) | 314 (24.2) | ||||