Table 1 Clinical features of patients of the pedigree with maturity-onset diabetes of the young (HNF1A-MODY)
From: Genetic diagnosis and treatment of a Chinese ketosis-prone MODY 3 family with depression
| Â | III3 | III4 | II4 |
|---|---|---|---|
Age (years) | 27 | 22 | 55 |
Age at diagnosis (years) | 18 | 21 | 49 |
BMI (kg/m2) | 16.45 | 19.96 | 18.90 |
HbA1C mmol/mol (%) | – | 54 (7.1) | – |
FBG (mmol/l) | 6.09 | 8.32 | 3.34 |
2-h PPG (mmol/l) | 11.65 | 20.02 | – |
Fasting C-peptide (pmol/L) | 114.9 | 341.3 | – |
2-h postprandial C-peptide (pmol/L) | – | 926.4 | 153.7 |
GAD-Ab | Negative | Negative | Negative |
IA2-Ab | Negative | Negative | Negative |
ZnT8-Ab | Negative | Negative | Negative |
Creatinine (ÎĽmol/L) | 59.9 | 69.0 | 66.3 |
Urea nitrogen (mmol/L) | 5.23 | – | 4.16 |
Uric acid (ÎĽmol/L) | 315.2 | 280.5 | 260.4 |
Alanine aminotransferase (U/L) | 11.4 | 11.9 | 23.9 |
Aspartate aminotransferase (U/L) | 23.1 | 15.8 | 33.4 |
Triglycerides (mmol/L) | 1.06 | 1.24 | 0.87 |
Total cholesterol (mmol/L) | 5.49 | 4.98 | 4.02 |
HDL-C (mmol/L) | 1.57 | – | 1.41 |
LDL-C (mmol/L) | 3.53 | – | 2.19 |
Hs-CRP (mg/L) | 0.09 | 0.28 | – |
Medication | Insulin | Sulphonylurea | Sulphonylurea |