Skip to main content

Table 1 Clinical features of patients of the pedigree with maturity-onset diabetes of the young (HNF1A-MODY)

From: Genetic diagnosis and treatment of a Chinese ketosis-prone MODY 3 family with depression

  III3 III4 II4
Age (years) 27 22 55
Age at diagnosis (years) 18 21 49
BMI (kg/m2) 16.45 19.96 18.90
HbA1C mmol/mol (%) 54 (7.1)
FBG (mmol/l) 6.09 8.32 3.34
2-h PPG (mmol/l) 11.65 20.02
Fasting C-peptide (pmol/L) 114.9 341.3
2-h postprandial C-peptide (pmol/L) 926.4 153.7
GAD-Ab Negative Negative Negative
IA2-Ab Negative Negative Negative
ZnT8-Ab Negative Negative Negative
Creatinine (μmol/L) 59.9 69.0 66.3
Urea nitrogen (mmol/L) 5.23 4.16
Uric acid (μmol/L) 315.2 280.5 260.4
Alanine aminotransferase (U/L) 11.4 11.9 23.9
Aspartate aminotransferase (U/L) 23.1 15.8 33.4
Triglycerides (mmol/L) 1.06 1.24 0.87
Total cholesterol (mmol/L) 5.49 4.98 4.02
HDL-C (mmol/L) 1.57 1.41
LDL-C (mmol/L) 3.53 2.19
Hs-CRP (mg/L) 0.09 0.28
Medication Insulin Sulphonylurea Sulphonylurea