Fig. 4

Reduced plasma insulin concentrations and elevated plasma glucagon concentrations in rats 2 weeks after intragastric administration of 3DG, n = 6 for each group. Plasma insulin concentrations (a) and glucagon concentrations (b) were measured before and after oral glucose load (2.5 g/kg) in 3DG (5, 20, 50 mg/kg) or vehicle-treated rats for 2 weeks. Values are mean ± SD. ^# p < 0.05, ^# p < 0.01 ^### p < 0.001 compared with control group at the same point (a, b). *p < 0.05, ***p < 0.001 compared with control group (a, b)