Table 2 Linear regression analysis for the association of adiponectin with clinical and biochemical variables
Variables | Univariate | Multiple | ||
|---|---|---|---|---|
β (95% CI) | P | β (95% CI) | P | |
Age (per 1 year) | 0.005 (0.002 to 0.008) | 0.004 | 0.002 (−0.002 to 0.005) | 0.346 |
Sex (male) | −0.366 (−0.450 to −0.283) | <0.001 | −0.067 (−0.196 to 0.061) | 0.305 |
Smoking | −0.224 (−0.307 to −0.141) | <0.001 | 0.002 (−0.111 to 0.115) | 0.975 |
Body mass index (per 1 kg/m2) | −0.053 (−0.065 to −0.041) | <0.001 |  |  |
Waist circumference (per 1 cm) | −0.020 (−0.024 to −0.016) | <0.001 | −0.008 (−0.013 to −0.003) | 0.002 |
Systolic blood pressure (per 10 mmHg) | 0.007 (−0.019 to 0.033) | 0.584 |  |  |
Diastolic blood pressure (per 10 mmHg) | −0.005 (−0.042 to 0.033) | 0.811 |  |  |
Laboratory findings | ||||
 Hemoglobin (per 1 g/dL) | −0.159 (−0.178 to −0.139) | <0.001 | −0.069 (−0.099 to −0.039) | <0.001 |
 Albumin (per 1 g/dL) | −0.572 (−0.672 to −0.473) | <0.001 | −0.326 (−0.451 to −0.202) | <0.001 |
 Glucose (per 10 mg/dL) | −0.012 (−0.024 to −0.001) | 0.041 | −0.009 (−0.021 to 0.003) | 0.130 |
 Uric acid (per 1 mg/dL) | 0.014 (−0.007 to 0.036) | 0.179 |  |  |
 Calcium (per 1 mg/dL) | −0.127 (−0.220 to −0.034) | 0.008 |  |  |
 Phosphate (per 1 mg/dL) | 0.284 (0.222 to 0.345) | <0.001 |  |  |
 Cholesterol (per 10 mg/dL) | 0.015 (0.004 to 0.026) | 0.008 |  |  |
 Triglyceride (per 1 log)a | −0.332 (−0.408 to −0.256) | <0.001 | −0.192 (−0.283 to −0.101) | <0.001 |
 HDL-C (per 10 mg/dL) | 0.116 (0.090 to 0.142) | <0.001 | 0.097 (0.066 to 0.128) | <0.001 |
 LDL-C (per 10 mg/dL) | 0.009 (−0.005 to 0.023) | 0.201 |  |  |
 hs-CRP (per 1 log)a | −0.050 (−0.076 to −0.024) | <0.001 | −0.053 (−0.080 to −0.026) | <0.001 |
 UACR (per 1 log)a | 0.088 (0.062 to 0.113) | <0.001 | 0.028 (−0.001 to 0.056) | 0.055 |
 eGFR (per 10 mL/min/1.73 m2) | −0.066 (−0.080 to −0.052) | <0.001 | −0.059 (−0.078 to −0.041) | <0.001 |
Co-morbidities | ||||
 Diabetes mellitus | 0.018 (−0.072 to 0.108) | 0.693 |  |  |
 Hypertension | −0.021 (−0.175 to 0.132) | 0.786 |  |  |
 Coronary artery disease | 0.071 (−0.088 to 0.230) | 0.379 |  |  |
 Peripheral artery disease | 0.116 (−0.198 to 0.429) | 0.470 |  |  |
 Cerebrovascular disease | 0.010 (−0.139 to 0.159) | 0.897 |  |  |
 Congestive heart failure | −0.363 (−0.823 to 0.098) | 0.122 |  |  |
 Arrhythmia | −0.156 (−0.441 to 0.130) | 0.285 |  |  |
Medications | ||||
 ACEi | 0.045 (−0.082 to 0.171) | 0.490 |  |  |
 ARB | −0.089 (−0.203 to 0.024) | 0.123 |  |  |
 Diuretics | 0.141 (0.051 to 0.231) | 0.002 | 0.042 (−0.052 to 0.137) | 0.377 |
 Beta blocker | −0.059 (−0.153 to 0.035) | 0.221 |  |  |
 Statin | −0.051 (−0.135 to 0.033) | 0.236 |  |  |
 Ezetimibe | −0.081 (−0.243 to 0.081) | 0.328 |  |  |
 Fibrate | −0.509 (−0.785 to −0.233) | <0.001 | −0.358 (−0.627 to −0.089) | 0.009 |