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Table 2 Linear regression analysis for the association of adiponectin with clinical and biochemical variables

From: Hypoadiponectinemia and the presence of metabolic syndrome in patients with chronic kidney disease: results from the KNOW-CKD study

Variables Univariate Multiple
β (95% CI) P β (95% CI) P
Age (per 1 year) 0.005 (0.002 to 0.008) 0.004 0.002 (−0.002 to 0.005) 0.346
Sex (male) −0.366 (−0.450 to −0.283) <0.001 −0.067 (−0.196 to 0.061) 0.305
Smoking −0.224 (−0.307 to −0.141) <0.001 0.002 (−0.111 to 0.115) 0.975
Body mass index (per 1 kg/m2) −0.053 (−0.065 to −0.041) <0.001   
Waist circumference (per 1 cm) −0.020 (−0.024 to −0.016) <0.001 −0.008 (−0.013 to −0.003) 0.002
Systolic blood pressure (per 10 mmHg) 0.007 (−0.019 to 0.033) 0.584   
Diastolic blood pressure (per 10 mmHg) −0.005 (−0.042 to 0.033) 0.811   
Laboratory findings
 Hemoglobin (per 1 g/dL) −0.159 (−0.178 to −0.139) <0.001 −0.069 (−0.099 to −0.039) <0.001
 Albumin (per 1 g/dL) −0.572 (−0.672 to −0.473) <0.001 −0.326 (−0.451 to −0.202) <0.001
 Glucose (per 10 mg/dL) −0.012 (−0.024 to −0.001) 0.041 −0.009 (−0.021 to 0.003) 0.130
 Uric acid (per 1 mg/dL) 0.014 (−0.007 to 0.036) 0.179   
 Calcium (per 1 mg/dL) −0.127 (−0.220 to −0.034) 0.008   
 Phosphate (per 1 mg/dL) 0.284 (0.222 to 0.345) <0.001   
 Cholesterol (per 10 mg/dL) 0.015 (0.004 to 0.026) 0.008   
 Triglyceride (per 1 log)a −0.332 (−0.408 to −0.256) <0.001 −0.192 (−0.283 to −0.101) <0.001
 HDL-C (per 10 mg/dL) 0.116 (0.090 to 0.142) <0.001 0.097 (0.066 to 0.128) <0.001
 LDL-C (per 10 mg/dL) 0.009 (−0.005 to 0.023) 0.201   
 hs-CRP (per 1 log)a −0.050 (−0.076 to −0.024) <0.001 −0.053 (−0.080 to −0.026) <0.001
 UACR (per 1 log)a 0.088 (0.062 to 0.113) <0.001 0.028 (−0.001 to 0.056) 0.055
 eGFR (per 10 mL/min/1.73 m2) −0.066 (−0.080 to −0.052) <0.001 −0.059 (−0.078 to −0.041) <0.001
Co-morbidities
 Diabetes mellitus 0.018 (−0.072 to 0.108) 0.693   
 Hypertension −0.021 (−0.175 to 0.132) 0.786   
 Coronary artery disease 0.071 (−0.088 to 0.230) 0.379   
 Peripheral artery disease 0.116 (−0.198 to 0.429) 0.470   
 Cerebrovascular disease 0.010 (−0.139 to 0.159) 0.897   
 Congestive heart failure −0.363 (−0.823 to 0.098) 0.122   
 Arrhythmia −0.156 (−0.441 to 0.130) 0.285   
Medications
 ACEi 0.045 (−0.082 to 0.171) 0.490   
 ARB −0.089 (−0.203 to 0.024) 0.123   
 Diuretics 0.141 (0.051 to 0.231) 0.002 0.042 (−0.052 to 0.137) 0.377
 Beta blocker −0.059 (−0.153 to 0.035) 0.221   
 Statin −0.051 (−0.135 to 0.033) 0.236   
 Ezetimibe −0.081 (−0.243 to 0.081) 0.328   
 Fibrate −0.509 (−0.785 to −0.233) <0.001 −0.358 (−0.627 to −0.089) 0.009
  1. aLog transformed, adiponectin was also transformed by log
  2. HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, hs-CRP high sensitivity C-reactive protein, UACR urinary albumin-to-creatinine ratio, eGFR estimated glomerular filtration rate, ACEi angiotensin converting enzyme inhibitor, ARB angiotensin II receptor blocker