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Table 4 The extracted antidiabetic medication prescription data obtained in the retrospective cohort study

From: Changes in antidiabetic prescription patterns and indicators of diabetic control among 200,000 patients over 13 years at a single institution in Japan

Year

2001

2005

2010

2013

rs#

p value#

n

170

170

170

170

  

Sulfonylureas (%)

78 (46)

63 (37)

67 (39)

59 (35)

 

0.02*

Glimepiride (n)

12

31

54

47

  

Glimepiridea (mg)

3 (2, 5.625) [1, 6]

3 (2, 4) [1, 6]

1.875 (1, 3) [0.5, 6]

1 (0.5, 2) [0.5, 6]

−0.45

<0.01

Biguanide (%)

78 (46)

83 (49)

84 (49)

76 (45)

 

0.76*

Metformin (n)

77

83

84

76

  

Metformina (mg)

750 (750, 750) [375, 750]

750 (750, 750) [250, 750]

750 (750, 750) [250, 1000]

750 (750, 1500) [250, 2250]

0.28

<0.01

Thiazolidine (%)

5 (3)

35 (21)

83 (49)

48 (28)

 

<0.01*

Pioglitazonea (mg)

30 (30, 30) [30]

15 (15, 30) [7.5, 30]

15 (15, 30) [7.5, 45]

15 (15, 30) [7.5, 45]

0.06

0.16

α-GI (%)

54 (32)

56 (33)

60 (35)

43 (25)

 

0.30*

Voglibose (n)

43

50

52

37

  

Voglibosea (mg)

0.9 (0.6, 0.9) [0.4, 0.9]

0.6 (0.6, 0.9) [0.2, 0.9]

0.9 (0.6, 0.9) [0.2, 0.9]

0.9 (0.6, 0.9) [0.3, 0.9]

0.26

<0.01

Meglitinides (%)

12 (7)

15 (9)

22 (13)

8 (5)

 

0.44*

Nateglinide (n)

12

15

19

6

  

Nateglinidea (mg)

270 (270, 270) [270, 270]

270 (270, 270) [60, 270]

270 (180, 270) [60, 360]

135 (90, 225) [90, 360]

−0.18

0.01

DPP4I (%)

0 (0)

0 (0)

1 (1)

70 (41)

 

<0.01*

Sitagliptin (n)

0

0

1

52

  

Sitagliptina (mg)

  

50 (50, 50) [50, 50]

50 (25, 50) [25, 100]

0.09

0.30

Insulins (%)

69 (41)

96 (57)

97 (57)

93 (55)

 

<0.01*

  1. Median (interquartile range) [range] or n (%)
  2. α-GI α-glucosidase inhibitors, DPP4I dipeptidyl peptidase-4 inhibitors
  3. # Analysis results over 13 years; Additional file 4 shows this in detail
  4. * According to the Cochran-Armitage trend test
  5. aYearly median daily dose for each patient