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Table 1 Summary of anthropometric and biochemical data obtained in the whole study population, in the euthyroid metformin-treated obese diabetic subpopulation (OB-EuM) and the euthyroid obese metformin-untreated subpopulation (Ob-Eu)

From: The impact of the metabolic phenotype on thyroid function in obesity

Variables Whole population (n = 952) OB-EuM (n = 306) Ob-Eu (n = 646) p
Males/females 410/542 127/179 283/363 0.5
Age (years) 56 (49–65) 58 (50–65) 55 (48–65) 0.07
BMI (kg/m2) 44.4 (40.5–48.9) 45.6 (41.4–49.6) 43.7 (40.0–48.7) 0.003
Weight (kg) 117.8 (102.8–133.5) 118.3 (106.0–134.0) 117.3 (101.6–133.1) 0.09
Height (cm) 161.8 (155–171) 161 (155–170) 162 (155–171) 0.3
Waist (cm) 129 (119–138) 131 (122–140) 127 (116–137) <0.001
Waist-to-hip ratio 0.96 (0.89–1.92) 0.97 (0.91–1.04) 0.94 (0.88–1.02) <0.001
REE (kcal/day) 1909 (1651–2247) 1963 (1740–2280) 1884 (1598–2233) 0.003
Fat mass (%) 46.3 (41.0–51.8) 47.3 (41.9–52.6) 45.7 (40.4–51.3) 0.009
Body water (%) 39.7 (36.2–44.2) 39.5 (36.3–43.9) 39.8 (36.2–44.4) 0.7
TSH (mIU/L) 1.72 (1.21–2.47) 1.72 (1.19–2.45) 1.72 (1.22–2.47) 0.7
fT4 (nmol/L) 146.3 (132.5–162.1) 151.9 (135.1–163.5) 145.4 (131.3–162.2) <0.001
Insulin (pmol/L) 100.7 (65.9–145.8) 98.6 (62.5–150.0) 102.1 (68.1–143.1) 0.5
Glucose (mmol/L) 5.77 (5.05–7.21) 7.38 (6.05–8.99) 5.38 (5.38–6.22) <0.001
HbA1c (%) 6.6 (6.0–7.9) 7.5 (6.5–8.7) 6.1 (5.7–6.7) <0.001
HOMA-IR 4.0 (2.5–6.1) 4.7 (2.9–7.2) 3.7 (2.3–5.6) <0.001
HOMA-B 125.2 (72.1–214.1) 76.3 (42.6–133.1) 152.0 (97.1–248.3) <0.001
Cholesterol (mmol/L) 5.10 (4.38–5.80) 4.79 (4.01–5.44) 5.26 (4.66–5.98) <0.001
LDL (mmol/L) 3.12 (2.49–3.76) 2.75 (2.16–3.39) 3.30 (2.70–3.93) <0.001
HDL (mmol/L) 1.09 (0.91–1.35) 1.04 (0.85–1.27) 1.11 (0.93–1.37) <0.001
Triglycerides (mmol/L) 1.59 (1.23–2.18) 1.73 (1.31–2.37) 1.55 (1.20–2.09) <0.001
AST (μkat/L) 0.35 (0.28–0.48) 0.35 (0.28–0.50) 0.35 (0.30–0.48) 0.8
ALT (μkat/L) 0.45 (0.32–0.70) 0.43 (0.32–0.70) 0.45 (0.32–0.70) 0.8
γGT (μkat/L) 0.48 (0.32–0.75) 0.50 (0.33–0.87) 0.47 (0.30–0.72) 0.07
ALP (μkat/L) 1.64 (1.14–3.02) 1.25 (1.04–1.65) 2.27 (1.25–3.35) <0.001
CRP (nmol/L) 5.71 (2.86–10.48) 5.71 (2.86–11.43) 5.71 (3.81–10.48) 0.5
Fibrinogen (μmol/L) 11.64 (10.17–13.38) 11.44 (9.91–13.17) 11.76 (10.29–13.52) 0.04
  1. HbA1c levels in Ob-Eu refer to measurement in a subgroup of 290 patients. Data are expressed as medians (with interquartile range in parentheses). Comparison between populations was performed by Mann–Whitney test on log-transformed data and χ2 test
  2. BMI body mass index; REE resting energy expenditure; HOMA-IR homeostatic model of insulin resistance; HOMA-B homeostatic model of β cell function; LDL low density lipoprotein; HDL high density lipoprotein; AST aspartate aminotransferase; ALT alanine aminotransferase; γGT gamma glutamiltransferase; ALP alkaline phosphatase; CRP C-reactive protein