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Table 3 Diplotype- and sex-based logistic regression analysis

From: Methylation quantitative trait loci within the TOMM20 gene are associated with metabolic syndrome-related lipid alterations in severely obese subjects

 

All

Men

Women

Wald χ2 (P value)

OR (95 % CI)

Wald χ2 (P value)

OR (95 % CI)

Wald χ2 (P value)

OR (95 % CI)

Total-C

H1/H2

5.9 (0.01)

2.03 (1.59–3.59)

4.7 (0.03)

3.00 (1.11–8.06)

1.7 (0.19)

1.60 (0.79–3–24)

 

H1/H3

1.5 (0.23)

1.29 (0.85–1.96)

4.3 (0.04)

2.10 (1.04–4.25)

0.0 (0.99)

1.00 (0.60–1.68)

LDL–C

H1/H2

4.6 (0.03)

1.86 (1.06–3.27)

6.2 (0.01)

3.54 (1.31–9.58)

0.6 (0.45)

1.31 (0.65–2.62)

 

H1/H3

1.9 (0.17)

1.34 (0.89–2.02)

7.1 (0.008)

2.64 (1.29–5.41)

0.1 (0.80)

0.94 (0.57–1.55)

TG

H1/H2

8.1 (0.004)

2.19 (1.28–3.74)

9.8 (0.002)

7.02 (2.07–13.76)

1.4 (0.24)

1.46 (0.78–272)

 

H1/H3

3.3 (0.03)

1.53 (1.03–2.26)

6.1 (0.01)

2.43 (1.20–4.93)

0.3 (0.57)

1.14 (0.73–1.78)

  1. Diplotype-based logistic regression analyses were fitted including sex, age and BMI as confounding factors in the entire population (n = 1720), and including age and BMI when men and women were analyzed separately (n = 537 and n = 1183, respectively). The H3/H3 diplotype was set as the reference group for comparison purposes since it carries wild type alleles of the four meQTLs tested. Significant Wald-tests are shown in italic face (P ≤ 0.05)
  2. OR odds ratio, CI 95 % Wald’s confidence intervals, Total-C total cholesterol, LDL-C low-density lipoprotein cholesterol, TG triglycerides