| |
All
|
Men
|
Women
|
|---|
|
Wald χ2 (P value)
|
OR (95 % CI)
|
Wald χ2 (P value)
|
OR (95 % CI)
|
Wald χ2 (P value)
|
OR (95 % CI)
|
|---|
|
Total-C
|
H1/H2
|
5.9 (0.01)
|
2.03 (1.59–3.59)
|
4.7 (0.03)
|
3.00 (1.11–8.06)
|
1.7 (0.19)
|
1.60 (0.79–3–24)
|
| |
H1/H3
|
1.5 (0.23)
|
1.29 (0.85–1.96)
|
4.3 (0.04)
|
2.10 (1.04–4.25)
|
0.0 (0.99)
|
1.00 (0.60–1.68)
|
|
LDL–C
|
H1/H2
|
4.6 (0.03)
|
1.86 (1.06–3.27)
|
6.2 (0.01)
|
3.54 (1.31–9.58)
|
0.6 (0.45)
|
1.31 (0.65–2.62)
|
| |
H1/H3
|
1.9 (0.17)
|
1.34 (0.89–2.02)
|
7.1 (0.008)
|
2.64 (1.29–5.41)
|
0.1 (0.80)
|
0.94 (0.57–1.55)
|
|
TG
|
H1/H2
|
8.1 (0.004)
|
2.19 (1.28–3.74)
|
9.8 (0.002)
|
7.02 (2.07–13.76)
|
1.4 (0.24)
|
1.46 (0.78–272)
|
| |
H1/H3
|
3.3 (0.03)
|
1.53 (1.03–2.26)
|
6.1 (0.01)
|
2.43 (1.20–4.93)
|
0.3 (0.57)
|
1.14 (0.73–1.78)
|
- Diplotype-based logistic regression analyses were fitted including sex, age and BMI as confounding factors in the entire population (n = 1720), and including age and BMI when men and women were analyzed separately (n = 537 and n = 1183, respectively). The H3/H3 diplotype was set as the reference group for comparison purposes since it carries wild type alleles of the four meQTLs tested. Significant Wald-tests are shown in italic face (P ≤ 0.05)
-
OR odds ratio, CI 95 % Wald’s confidence intervals, Total-C total cholesterol, LDL-C low-density lipoprotein cholesterol, TG triglycerides
