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Table 3 Diplotype- and sex-based logistic regression analysis

From: Methylation quantitative trait loci within the TOMM20 gene are associated with metabolic syndrome-related lipid alterations in severely obese subjects

  All Men Women
Wald χ2 (P value) OR (95 % CI) Wald χ2 (P value) OR (95 % CI) Wald χ2 (P value) OR (95 % CI)
Total-C H1/H2 5.9 (0.01) 2.03 (1.59–3.59) 4.7 (0.03) 3.00 (1.11–8.06) 1.7 (0.19) 1.60 (0.79–3–24)
  H1/H3 1.5 (0.23) 1.29 (0.85–1.96) 4.3 (0.04) 2.10 (1.04–4.25) 0.0 (0.99) 1.00 (0.60–1.68)
LDL–C H1/H2 4.6 (0.03) 1.86 (1.06–3.27) 6.2 (0.01) 3.54 (1.31–9.58) 0.6 (0.45) 1.31 (0.65–2.62)
  H1/H3 1.9 (0.17) 1.34 (0.89–2.02) 7.1 (0.008) 2.64 (1.29–5.41) 0.1 (0.80) 0.94 (0.57–1.55)
TG H1/H2 8.1 (0.004) 2.19 (1.28–3.74) 9.8 (0.002) 7.02 (2.07–13.76) 1.4 (0.24) 1.46 (0.78–272)
  H1/H3 3.3 (0.03) 1.53 (1.03–2.26) 6.1 (0.01) 2.43 (1.20–4.93) 0.3 (0.57) 1.14 (0.73–1.78)
  1. Diplotype-based logistic regression analyses were fitted including sex, age and BMI as confounding factors in the entire population (n = 1720), and including age and BMI when men and women were analyzed separately (n = 537 and n = 1183, respectively). The H3/H3 diplotype was set as the reference group for comparison purposes since it carries wild type alleles of the four meQTLs tested. Significant Wald-tests are shown in italic face (P ≤ 0.05)
  2. OR odds ratio, CI 95 % Wald’s confidence intervals, Total-C total cholesterol, LDL-C low-density lipoprotein cholesterol, TG triglycerides