| |
Study population
|
Methylation sub-population
|
|---|
|
MS+
|
MS−
|
MS+
|
MS−
|
|---|
|
Number of subjects
|
1402
|
315
|
25
|
23
|
|
Age (years)
|
43.9 ± 10.5
|
38.7 ± 9.8***
|
33.9 ± 9.4
|
32.0 ± 7.9
|
|
BMI (kg/m2)
|
51.8 ± 8.5
|
51.3 ± 8.7
|
52.6 ± 12.7
|
52.3 ± 8.4
|
|
Waist girth (cm)
|
141.5 ± 17.2
|
135.6 ± 18.5***
|
149.4 ± 24.8
|
143.3 ± 17.1
|
|
Fasting glucose (mmol/L)
|
6.85 ± 2.43
|
5.11 ± 0.98***
|
6.61 ± 2.79
|
4.95 ± 0.46**
|
|
Lipid profile (mmol/L)
|
|
Total-C
|
4.67 ± 0.96
|
4.80 ± 0.82*
|
4.93 ± 0.75
|
4.47 ± 0.87**
|
|
LDL-C
|
2.65 ± 0.83
|
2.79 ± 0.75**
|
2.89 ± 0.65
|
2.68 ± 0.77
|
|
HDL-C
|
1.18 ± 0.32
|
1.49 ± 0.37***
|
0.96 ± 0.19
|
1.28 ± 0.17***
|
|
TG
|
1.97 ± 1.12
|
1.17 ± 0.37***
|
2.40 ± 1.30
|
1.12 ± 0.45***
|
|
Total-C/HDL-C
|
4.18 ± 1.34
|
3.33 ± 0.74***
|
5.32 ± 1.49
|
3.51 ± 0.56***
|
|
Blood pressure (mm Hg)
|
|
SBP
|
139 ± 16.7
|
134.7 ± 15.7***
|
145 ± 19.8
|
130.8 ± 13.2**
|
|
DBP
|
84 ± 11.3
|
83.0 ± 10.3
|
89 ± 12.0
|
78.0 ± 9.7**
|
- Metabolic and anthropometric values in the study population (n = 1720) and in the methylation sub-population (n = 48) of severely obese subjects with and without MS (MS+ and MS−, respectively). Data is expressed as mean ±SD. Asterisks stand for significant differences between MS+ vs. MS− subjects using unpaired Student’s t test (*** P ≤ 0.0001, ** P ≤ 0.01, * P ≤ 0.05, ns: not significant)
-
BMI body mass index, Total-C total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, TG triglycerides, SBP systolic blood pressure, DBP diastolic blood pressure
