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Table 1 Characteristics of subjects

From: Methylation quantitative trait loci within the TOMM20 gene are associated with metabolic syndrome-related lipid alterations in severely obese subjects

  Study population Methylation sub-population
MS+ MS− MS+ MS−
Number of subjects 1402 315 25 23
Age (years) 43.9 ± 10.5 38.7 ± 9.8*** 33.9 ± 9.4 32.0 ± 7.9
BMI (kg/m2) 51.8 ± 8.5 51.3 ± 8.7 52.6 ± 12.7 52.3 ± 8.4
Waist girth (cm) 141.5 ± 17.2 135.6 ± 18.5*** 149.4 ± 24.8 143.3 ± 17.1
Fasting glucose (mmol/L) 6.85 ± 2.43 5.11 ± 0.98*** 6.61 ± 2.79 4.95 ± 0.46**
Lipid profile (mmol/L)
 Total-C 4.67 ± 0.96 4.80 ± 0.82* 4.93 ± 0.75 4.47 ± 0.87**
 LDL-C 2.65 ± 0.83 2.79 ± 0.75** 2.89 ± 0.65 2.68 ± 0.77
 HDL-C 1.18 ± 0.32 1.49 ± 0.37*** 0.96 ± 0.19 1.28 ± 0.17***
 TG 1.97 ± 1.12 1.17 ± 0.37*** 2.40 ± 1.30 1.12 ± 0.45***
 Total-C/HDL-C 4.18 ± 1.34 3.33 ± 0.74*** 5.32 ± 1.49 3.51 ± 0.56***
Blood pressure (mm Hg)
 SBP 139 ± 16.7 134.7 ± 15.7*** 145 ± 19.8 130.8 ± 13.2**
 DBP 84 ± 11.3 83.0 ± 10.3 89 ± 12.0 78.0 ± 9.7**
  1. Metabolic and anthropometric values in the study population (n = 1720) and in the methylation sub-population (n = 48) of severely obese subjects with and without MS (MS+ and MS−, respectively). Data is expressed as mean ±SD. Asterisks stand for significant differences between MS+ vs. MS− subjects using unpaired Student’s t test (*** P ≤ 0.0001, ** P ≤ 0.01, * P ≤ 0.05, ns: not significant)
  2. BMI body mass index, Total-C total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, TG triglycerides, SBP systolic blood pressure, DBP diastolic blood pressure