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Table 1 Haplotype and genotype HLA association and frequency comparison between double autoimmunity versus type 1 diabetes-only [16]

From: Screening for coeliac disease in adult patients with type 1 diabetes mellitus: myths, facts and controversy

  T1DM + CD versus T1DM OR (CI 95 %) p value
Frequency controls Frequency T1DM + CD Frequency T1DM only
Haplotype
DQ 2.5 0.14 0.446 0.318 1.442 (1.189, 1.748) 0.0003
DQ 2.2 0.094 0.046 0.040 1.201 (0.793, 1.821) 0.381
DQ8 0.1 0.346 0.392 0.939 (0.779, 1.131) 0.520
Other 0.663 0.163 0.249 0.660 (0.530, 0.821) 0.0001
Genotype
DQ 2.5/DQ 2.5 0.020 0.168 0.066 1.20 (1.14, 1.26) 0.0005
DQ 2.5/DQ 2.2 0.032 0.039 0.017 1.16 (1.06, 1.27) 0.242
DQ 2.5/DQ8 0.027 0.350 0.377 0.98 (0.95, 1.01) 0.681
DQ 2.5/other 0.184 0.168 0.112 1.07 (1.03, 1.11) 0.688
DQ 2.2/DQ 2.2 0.012 0.004 0.002 1.18 (0.88, 1.58) 0.169
DQ 2.2/DQ 8 0.022 0.033 0.036 0.98 (0.92, 1.06) 0.908
DQ 2.2/Other 0.111 0.010 0.025 0.91 (0.83, 0.99) 0.326
DQ 8/DQ 8 0.009 0.083 0.078 1.00 (0.96, 1.05) 0.886
DQ 8/Other 0.135 0.143 0.216 0.94 (0.91, 0.97) 0.175
Other/Other 0.449 0.002 0.072 0.84 (0.80, 0.89) 0.028
  1. CD coeliac disease, OR Odd’s ratio, T1DM type 1 diabetes mellitus