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Table 1 Haplotype and genotype HLA association and frequency comparison between double autoimmunity versus type 1 diabetes-only [16]

From: Screening for coeliac disease in adult patients with type 1 diabetes mellitus: myths, facts and controversy

 

T1DM + CD versus T1DM

OR (CI 95 %)

p value

Frequency controls

Frequency T1DM + CD

Frequency T1DM only

Haplotype

DQ 2.5

0.14

0.446

0.318

1.442 (1.189, 1.748)

0.0003

DQ 2.2

0.094

0.046

0.040

1.201 (0.793, 1.821)

0.381

DQ8

0.1

0.346

0.392

0.939 (0.779, 1.131)

0.520

Other

0.663

0.163

0.249

0.660 (0.530, 0.821)

0.0001

Genotype

DQ 2.5/DQ 2.5

0.020

0.168

0.066

1.20 (1.14, 1.26)

0.0005

DQ 2.5/DQ 2.2

0.032

0.039

0.017

1.16 (1.06, 1.27)

0.242

DQ 2.5/DQ8

0.027

0.350

0.377

0.98 (0.95, 1.01)

0.681

DQ 2.5/other

0.184

0.168

0.112

1.07 (1.03, 1.11)

0.688

DQ 2.2/DQ 2.2

0.012

0.004

0.002

1.18 (0.88, 1.58)

0.169

DQ 2.2/DQ 8

0.022

0.033

0.036

0.98 (0.92, 1.06)

0.908

DQ 2.2/Other

0.111

0.010

0.025

0.91 (0.83, 0.99)

0.326

DQ 8/DQ 8

0.009

0.083

0.078

1.00 (0.96, 1.05)

0.886

DQ 8/Other

0.135

0.143

0.216

0.94 (0.91, 0.97)

0.175

Other/Other

0.449

0.002

0.072

0.84 (0.80, 0.89)

0.028

  1. CD coeliac disease, OR Odd’s ratio, T1DM type 1 diabetes mellitus